RESEARCH ARTICLE
Influence of Pneumococcal Conjugate Vaccine on Acute Otitis Media with Severe Middle Ear Inflammation: A Retrospective Multicenter Study Hirotoshi Sugino1,2, Shigeru Tsumura1,3, Masaru Kunimoto1,4,5*, Masuhiro Noda1,6, Daisuke Chikuie1,7, Chieko Noda1,6, Mariko Yamashita1,8, Hiroshi Watanabe1,9, Hidemasa Ishii1,10, Toru Tashiro1,11, Kazuhiro Iwata1,10, Takashi Kono1,4,10, Kaoru Tsumura1,10, Takahiro Sumiya12, Sachio Takeno4, Katsuhiro Hirakawa4 1 Asa Medical Association, Hiroshima City, Japan, 2 Sugino Pediatric Clinic, Hiroshima City, Japan, 3 Tsumura ENT Clinic, Hiroshima City, Japan, 4 Department of Otolaryngology, Head and Neck Surgery, Graduate School of Biomedical & Health Sciences, Applied Life Sciences, Hiroshima University, Hiroshima City, Japan, 5 Kunimoto ENT Clinic, Hiroshima City, Japan, 6 Noda ENT Clinic, Hiroshima City, Japan, 7 Hiroshima Kyouritsu Hospital, Hiroshima City, Japan, 8 Yamashita Clinic, Hiroshima City, Japan, 9 Watanabe ENT Clinic, Hiroshima City, Japan, 10 Hiroshima City Asa Hospital, Hiroshima City, Japan, 11 Tashiro ENT Clinic, Hiroshima City, Japan, 12 Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima City, Japan * [email protected]
OPEN ACCESS Citation: Sugino H, Tsumura S, Kunimoto M, Noda M, Chikuie D, Noda C, et al. (2015) Influence of Pneumococcal Conjugate Vaccine on Acute Otitis Media with Severe Middle Ear Inflammation: A Retrospective Multicenter Study. PLoS ONE 10(9): e0137546. doi:10.1371/journal.pone.0137546 Editor: Ulla Kou Griffiths, London School of Hygiene and Tropical Medicine, UNITED KINGDOM Received: February 13, 2015 Accepted: August 18, 2015 Published: September 8, 2015 Copyright: © 2015 Sugino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: The authors received no specific funding for this work.
Abstract The Japanese guidelines for acute otitis media in children recommend classifying acute otitis media by age, manifestations and local findings, and also recommend myringotomy for moderate-grade cases with severe local findings, severe-grade cases, and treatment-resistant cases. The heptavalent pneumococcal conjugate vaccine was released in Japan in February 2010. In Hiroshima City, public funding allowing free inoculation with this vaccine was initiated from January 2011, and the number of vaccinated individuals has since increased dramatically. This study investigated changes in the number of myringotomies performed to treat acute otitis media during the 5-year period from January 2008 to December 2012 at two hospitals and five clinics in the Asa Area of Hiroshima City, Japan. A total of 3,165 myringotomies for acute otitis media were performed. The rate of procedures per child-year performed in
Influence of Pneumococcal Conjugate Vaccine on Acute Otitis Media with Severe Middle Ear Inflammation: A Retrospective Multicenter Study Hirotoshi Sugino1,2, Shigeru Tsumura1,3, Masaru Kunimoto1,4,5*, Masuhiro Noda1,6, Daisuke Chikuie1,7, Chieko Noda1,6, Mariko Yamashita1,8, Hiroshi Watanabe1,9, Hidemasa Ishii1,10, Toru Tashiro1,11, Kazuhiro Iwata1,10, Takashi Kono1,4,10, Kaoru Tsumura1,10, Takahiro Sumiya12, Sachio Takeno4, Katsuhiro Hirakawa4 1 Asa Medical Association, Hiroshima City, Japan, 2 Sugino Pediatric Clinic, Hiroshima City, Japan, 3 Tsumura ENT Clinic, Hiroshima City, Japan, 4 Department of Otolaryngology, Head and Neck Surgery, Graduate School of Biomedical & Health Sciences, Applied Life Sciences, Hiroshima University, Hiroshima City, Japan, 5 Kunimoto ENT Clinic, Hiroshima City, Japan, 6 Noda ENT Clinic, Hiroshima City, Japan, 7 Hiroshima Kyouritsu Hospital, Hiroshima City, Japan, 8 Yamashita Clinic, Hiroshima City, Japan, 9 Watanabe ENT Clinic, Hiroshima City, Japan, 10 Hiroshima City Asa Hospital, Hiroshima City, Japan, 11 Tashiro ENT Clinic, Hiroshima City, Japan, 12 Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima City, Japan * [email protected]
OPEN ACCESS Citation: Sugino H, Tsumura S, Kunimoto M, Noda M, Chikuie D, Noda C, et al. (2015) Influence of Pneumococcal Conjugate Vaccine on Acute Otitis Media with Severe Middle Ear Inflammation: A Retrospective Multicenter Study. PLoS ONE 10(9): e0137546. doi:10.1371/journal.pone.0137546 Editor: Ulla Kou Griffiths, London School of Hygiene and Tropical Medicine, UNITED KINGDOM Received: February 13, 2015 Accepted: August 18, 2015 Published: September 8, 2015 Copyright: © 2015 Sugino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: The authors received no specific funding for this work.
Abstract The Japanese guidelines for acute otitis media in children recommend classifying acute otitis media by age, manifestations and local findings, and also recommend myringotomy for moderate-grade cases with severe local findings, severe-grade cases, and treatment-resistant cases. The heptavalent pneumococcal conjugate vaccine was released in Japan in February 2010. In Hiroshima City, public funding allowing free inoculation with this vaccine was initiated from January 2011, and the number of vaccinated individuals has since increased dramatically. This study investigated changes in the number of myringotomies performed to treat acute otitis media during the 5-year period from January 2008 to December 2012 at two hospitals and five clinics in the Asa Area of Hiroshima City, Japan. A total of 3,165 myringotomies for acute otitis media were performed. The rate of procedures per child-year performed in
