Biol Trace Elem Res (2014) 160:305–310 DOI 10.1007/s12011-014-0044-2
Influence of Magnesium on Insulin Resistance in Obese Women Kyria Jayanne Clímaco Cruz & Ana Raquel Soares de Oliveira & Denise Pereira Pinto & Jennifer Beatriz Silva Morais & Fabiana da Silva Lima & Célia Colli & Francisco Leonardo Torres-Leal & Dilina do Nascimento Marreiro
Received: 19 May 2014 / Accepted: 9 June 2014 / Published online: 2 July 2014 # Springer Science+Business Media New York 2014
Abstract The present study evaluated the influence of magnesium on insulin resistance in obese women. A case-control study involving 114 women on the age between 20 and 50 years old, divided into two groups: control (eutrophic women, n=59) and case (obese women, n=55). The analysis of magnesium intake was carried out through the 3-day food record and also NutWin software version 1.5. The plasma, erythrocyte, and urinary magnesium concentrations were determined by flame atomic absorption spectrophotometry. The determinations of serum glucose and serum insulin were performed by enzymatic colorimetric method and chemiluminescence, respectively. The insulin resistance was assessed by homeostasis model assessment insulin resistance (HOMAIR). The mean values of magnesium intake were lower than those recommended, without difference between groups (p>0.05). All the patients who were evaluated showed adequate mean concentrations of magnesium in the plasma and erythrocyte. The urinary excretion of this mineral was lower than the reference values in both groups and did not show significant difference (p>0.05). The values of serum glucose, serum insulin, and HOMA-IR were higher in obese women compared to the control group. A negative correlation was K. J. C. Cruz : A. R. S. de Oliveira : D. P. Pinto : J. B. S. Morais : D. do Nascimento Marreiro (*) Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Ininga, Teresina, Piauí, Brazil e-mail: [email protected] F. da Silva Lima : C. Colli Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Butantã, São Paulo, São Paulo, Brazil F. L. Torres-Leal Department of Physiology and Biophysics, Federal University of Piauí, Campus Minister Petrônio Portela, Ininga, Teresina, Piauí, Brazil
observed between erythrocyte magnesium and glycemic parameters (p
Influence of Magnesium on Insulin Resistance in Obese Women Kyria Jayanne Clímaco Cruz & Ana Raquel Soares de Oliveira & Denise Pereira Pinto & Jennifer Beatriz Silva Morais & Fabiana da Silva Lima & Célia Colli & Francisco Leonardo Torres-Leal & Dilina do Nascimento Marreiro
Received: 19 May 2014 / Accepted: 9 June 2014 / Published online: 2 July 2014 # Springer Science+Business Media New York 2014
Abstract The present study evaluated the influence of magnesium on insulin resistance in obese women. A case-control study involving 114 women on the age between 20 and 50 years old, divided into two groups: control (eutrophic women, n=59) and case (obese women, n=55). The analysis of magnesium intake was carried out through the 3-day food record and also NutWin software version 1.5. The plasma, erythrocyte, and urinary magnesium concentrations were determined by flame atomic absorption spectrophotometry. The determinations of serum glucose and serum insulin were performed by enzymatic colorimetric method and chemiluminescence, respectively. The insulin resistance was assessed by homeostasis model assessment insulin resistance (HOMAIR). The mean values of magnesium intake were lower than those recommended, without difference between groups (p>0.05). All the patients who were evaluated showed adequate mean concentrations of magnesium in the plasma and erythrocyte. The urinary excretion of this mineral was lower than the reference values in both groups and did not show significant difference (p>0.05). The values of serum glucose, serum insulin, and HOMA-IR were higher in obese women compared to the control group. A negative correlation was K. J. C. Cruz : A. R. S. de Oliveira : D. P. Pinto : J. B. S. Morais : D. do Nascimento Marreiro (*) Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Ininga, Teresina, Piauí, Brazil e-mail: [email protected] F. da Silva Lima : C. Colli Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Butantã, São Paulo, São Paulo, Brazil F. L. Torres-Leal Department of Physiology and Biophysics, Federal University of Piauí, Campus Minister Petrônio Portela, Ininga, Teresina, Piauí, Brazil
observed between erythrocyte magnesium and glycemic parameters (p
