rum zinc. There is, therefore, in vivo and in vitro studies
in urinary
decrease
evidence that amino
in se-
from acid
binding of zinc might be. important in the transport of this divalent cation. This prompted us to study the influence of histidine administration on zinc metabolism in rats.
Materials Acute
infusion
and methods study
Twenty-two male Sprague-Dawley rats weighing between 160 to 260 g which had been previously maintained in a group cage with regular rat chow (containing 150 ppm zinc) and deionized water ad libitum were paired off for simultaneous infusions. The rats were anesthetized with sodium pentobarbital (0.2 ml intra-
peritoneally The American
7.58
±
the prehistidine
at the end
of solution Journal
containing of
Clinical
50 mg/mI), Nutrition
ml,
increased
that protein-bound in two forms one
a 6- to 20-fold
as well
than zinc
diluent
and a 30: APRIL
zinc
lesions
urinary
Nutr.
0.97,
20.21
however,
the
hour
During ±
value
the
2.07, and and
higher
was 76 ± 5 tag/1 00 studies:
histidine
(500
in histidine treated rats was no difference in the deficiency
in the
30: 523-527,
metabo-
by constant
During pg/hr.
infusion
of zinc
excretion
deficiency,
J. Clin.
alone. (SE) infusion
of the
No histological
testicular,
esophagus.
levels
loosely bound to albumin. It has been more recently suggested that a small percentage of zinc is bound to amino acids (in particular histidine
zinc
averaged
on zinc was given
± 0.37
plasma,
Vikbladh (1) suggested zinc is in the plasma
cysteine)
0.435
Chronic
to control
The status of zinc in circulating been of interest for several years