ORIGINAL ARTICLE: GASTROENTEROLOGY
Influence of Enteral Nutrition on Occurrences of Necrotizing Enterocolitis in Very-Low-Birth-Weight Infants
Karine S. Kimak, yMargarida M. de Castro Antunes, zTaciana D. Braga, y Katia G. Brandt, and yMarilia de Carvalho Lima
ABSTRACT Objective: The aim of the present study was to investigate the influence of enteral feeding management on occurrences of necrotizing enterocolitis (NEC) in very-low-birth-weight (VLBW) infants. Methods: This was a case-control study conducted in a sample of 1028 VLBW infants (750 to 1499 g) admitted to a neonatal intensive care unit between January 2003 and May 2008. ‘‘Cases’’ were infants born with VLBW and diagnosed with NEC within the first 30 days of life, and ‘‘controls’’ were VLBW infants who did not develop NEC during this period. Occurrences of NEC were defined using the modified Bell criteria (stage 2). Results: Among the 1028 VLBW infants, 55 (5.4%) developed NEC within the first month of life. Logistic regression analysis showed that breast milk given exclusively for 30 mL kg1 day1 were analyzed, the children who received this progression on certain days presented protection against NEC development. In the studied group, the VLBW infants who received parenteral nutrition had a higher risk of developing NEC. This greater occurrence of NEC could be explained by the characteristics of the group in which parenteral nutrition was more frequently indicated. Parenteral nutrition was implemented most often among infants born with a low weight (750 to 1249 g) who started feeding on the fifth day or later (results not shown). The duration of the use of parenteral nutrition, however, did not increase the probability of developing NEC because the mean duration of parenteral nutrition was similar between the groups that did and did not develop enterocolitis. In fact, a meta-analysis concluded that the use of www.jpgn.org
Copyright 2015 by ESPGHAN and NASPGHAN. Unauthorized reproduction of this article is prohibited.
JPGN
Volume 61, Number 4, October 2015
Enteral Nutrition and Necrotizing Enterocolitis
TABLE 4. Logistic regression of factors associated with NEC in VLBW infants NEC Variables
Yes
Level 1 Duration of exclusive human milk
Influence of Enteral Nutrition on Occurrences of Necrotizing Enterocolitis in Very-Low-Birth-Weight Infants
Karine S. Kimak, yMargarida M. de Castro Antunes, zTaciana D. Braga, y Katia G. Brandt, and yMarilia de Carvalho Lima
ABSTRACT Objective: The aim of the present study was to investigate the influence of enteral feeding management on occurrences of necrotizing enterocolitis (NEC) in very-low-birth-weight (VLBW) infants. Methods: This was a case-control study conducted in a sample of 1028 VLBW infants (750 to 1499 g) admitted to a neonatal intensive care unit between January 2003 and May 2008. ‘‘Cases’’ were infants born with VLBW and diagnosed with NEC within the first 30 days of life, and ‘‘controls’’ were VLBW infants who did not develop NEC during this period. Occurrences of NEC were defined using the modified Bell criteria (stage 2). Results: Among the 1028 VLBW infants, 55 (5.4%) developed NEC within the first month of life. Logistic regression analysis showed that breast milk given exclusively for 30 mL kg1 day1 were analyzed, the children who received this progression on certain days presented protection against NEC development. In the studied group, the VLBW infants who received parenteral nutrition had a higher risk of developing NEC. This greater occurrence of NEC could be explained by the characteristics of the group in which parenteral nutrition was more frequently indicated. Parenteral nutrition was implemented most often among infants born with a low weight (750 to 1249 g) who started feeding on the fifth day or later (results not shown). The duration of the use of parenteral nutrition, however, did not increase the probability of developing NEC because the mean duration of parenteral nutrition was similar between the groups that did and did not develop enterocolitis. In fact, a meta-analysis concluded that the use of www.jpgn.org
Copyright 2015 by ESPGHAN and NASPGHAN. Unauthorized reproduction of this article is prohibited.
JPGN
Volume 61, Number 4, October 2015
Enteral Nutrition and Necrotizing Enterocolitis
TABLE 4. Logistic regression of factors associated with NEC in VLBW infants NEC Variables
Yes
Level 1 Duration of exclusive human milk
