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Official journal of the American Society of Gene & Cell Therapy

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Inducible HGF-secreting Human Umbilical Cord Blood-derived MSCs Produced via TALEN-mediated Genome Editing Promoted Angiogenesis Hyun-Kyung Chang1, Pyung-Hwan Kim1,2, Hyun-Min Cho1, Soo-Young Yum3, Young-Jin Choi1, YeonSung Son1, DaBin Lee1, InSung Kang4, Kyung-Sun Kang4, Goo Jang3 and Je-Yoel Cho1 1 Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea; 2Current address: Department of Biomedical Laboratory Science, College of ­Medical Science, Konyang University, Daejeon, South Korea; 3Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National ­University, Seoul, South Korea; 4Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, South Korea

Mesenchymal stem cells (MSCs) promote therapeutic angiogenesis to cure serious vascular disorders. However, their survival period and cytokine-secretory capacity are limited. Although hepatocyte growth factor (HGF) can accelerate the rate of angiogenesis, recombinant HGF is limited because of its very short half-life (