International Orthopaedics (SICOT) (2014) 38:1971–1978 DOI 10.1007/s00264-014-2422-y
REVIEW ARTICLE
Induced membrane for treatment of critical sized bone defect: a review of experimental and clinical experiences Jean-Charles Aurégan & Thierry Bégué
Received: 5 June 2014 / Accepted: 7 June 2014 / Published online: 2 July 2014 # SICOT aisbl 2014
Abstract Purpose The purpose of this study was to review experimental and clinical experiences about the use of an induced membrane to address critical bone size defect of the limbs. Methods From a review of published experimental and clinical data and from our clinical experience, we present the key data about the use of an induced membrane to address critical bone size defect of the limbs. Results After reviewing the concept of critical sized bone defect, we present the different indications of an induced membrane, the key points of the surgical technique and the strategy of bone grafting given the indication, localization and importance of the critical sized bone defect. Finally, we discuss the perspective of the use of an induced membrane with various bone substitutes. Conclusions The use of an induced membrane to treat critical sized bone defects of the limbs is a simple, reliable and reproducible technique. Certain technical steps should be pointed out and observed with great caution in order to avoid any pitfalls. This technique will probably be a key step for facilitating bone inclusion of new bone substitutes proposed by recent bioengineering.
Keywords Critical sized bone defect . Induced membrane . Bone graft . Bone morphogenetic proteins J.
REVIEW ARTICLE
Induced membrane for treatment of critical sized bone defect: a review of experimental and clinical experiences Jean-Charles Aurégan & Thierry Bégué
Received: 5 June 2014 / Accepted: 7 June 2014 / Published online: 2 July 2014 # SICOT aisbl 2014
Abstract Purpose The purpose of this study was to review experimental and clinical experiences about the use of an induced membrane to address critical bone size defect of the limbs. Methods From a review of published experimental and clinical data and from our clinical experience, we present the key data about the use of an induced membrane to address critical bone size defect of the limbs. Results After reviewing the concept of critical sized bone defect, we present the different indications of an induced membrane, the key points of the surgical technique and the strategy of bone grafting given the indication, localization and importance of the critical sized bone defect. Finally, we discuss the perspective of the use of an induced membrane with various bone substitutes. Conclusions The use of an induced membrane to treat critical sized bone defects of the limbs is a simple, reliable and reproducible technique. Certain technical steps should be pointed out and observed with great caution in order to avoid any pitfalls. This technique will probably be a key step for facilitating bone inclusion of new bone substitutes proposed by recent bioengineering.
Keywords Critical sized bone defect . Induced membrane . Bone graft . Bone morphogenetic proteins J.
