www.nature.com/scientificreports
OPEN
received: 09 May 2016 accepted: 10 August 2016 Published: 09 September 2016
Indole-3- carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study Mai M. Abdelmageed1, Reem N. El-Naga2, Ebtehal El-Demerdash2,3 & Mohamed M. Elmazar1 Sorafenib is the only chemotherapeutic agent currently approved for unresectable hepatocellular carcinoma (HCC). However, poor response rates have been widely reported. Indole-3-carbinol (I3C) is a potential chemopreventive phytochemical. The present study aimed to explore the potential chemomodulatory effects of I3C on sorafenib in HCC cells as well as the possible underlying mechanisms. I3C exhibited a greater cytotoxicity in HepG2 cells compared to Huh-7 cells (p
OPEN
received: 09 May 2016 accepted: 10 August 2016 Published: 09 September 2016
Indole-3- carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study Mai M. Abdelmageed1, Reem N. El-Naga2, Ebtehal El-Demerdash2,3 & Mohamed M. Elmazar1 Sorafenib is the only chemotherapeutic agent currently approved for unresectable hepatocellular carcinoma (HCC). However, poor response rates have been widely reported. Indole-3-carbinol (I3C) is a potential chemopreventive phytochemical. The present study aimed to explore the potential chemomodulatory effects of I3C on sorafenib in HCC cells as well as the possible underlying mechanisms. I3C exhibited a greater cytotoxicity in HepG2 cells compared to Huh-7 cells (p
