RESEARCH ARTICLE
Increased risk for development of coronary artery calcification in subjects with nonalcoholic fatty liver disease and systemic inflammation Jihyun Kim, Da Young Lee, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee* Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
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* [email protected]
Abstract Background
OPEN ACCESS Citation: Kim J, Lee DY, Park SE, Park C-Y, Lee WY, Oh K-W, et al. (2017) Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation. PLoS ONE 12(7): e0180118. https://doi.org/10.1371/journal. pone.0180118 Editor: Susanne Kaser, Medical University Innsbruck, AUSTRIA Received: November 23, 2016 Accepted: June 11, 2017 Published: July 7, 2017 Copyright: © 2017 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors received no specific funding for this work. Competing interests: The authors have declared that no competing interests exist.
Recent studies have suggested the importance of non-alcoholic fatty liver disease (NAFLD) and systemic inflammation in the development of atherosclerosis. The aim of this study was to compare the risk for coronary artery calcification (CAC) development according to the status of NAFLD and inflammation over four years of follow-up in subjects without baseline CAC.
Methods A total of 1,575 participants in a health screening program were divided into four groups according to baseline NAFLD state and high-sensitivity C-reactive protein (hs-CRP) (median 0.06 mg/L) levels as follows: no NAFLD and hs-CRP
Increased risk for development of coronary artery calcification in subjects with nonalcoholic fatty liver disease and systemic inflammation Jihyun Kim, Da Young Lee, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee* Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
a1111111111 a1111111111 a1111111111 a1111111111 a1111111111
* [email protected]
Abstract Background
OPEN ACCESS Citation: Kim J, Lee DY, Park SE, Park C-Y, Lee WY, Oh K-W, et al. (2017) Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation. PLoS ONE 12(7): e0180118. https://doi.org/10.1371/journal. pone.0180118 Editor: Susanne Kaser, Medical University Innsbruck, AUSTRIA Received: November 23, 2016 Accepted: June 11, 2017 Published: July 7, 2017 Copyright: © 2017 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors received no specific funding for this work. Competing interests: The authors have declared that no competing interests exist.
Recent studies have suggested the importance of non-alcoholic fatty liver disease (NAFLD) and systemic inflammation in the development of atherosclerosis. The aim of this study was to compare the risk for coronary artery calcification (CAC) development according to the status of NAFLD and inflammation over four years of follow-up in subjects without baseline CAC.
Methods A total of 1,575 participants in a health screening program were divided into four groups according to baseline NAFLD state and high-sensitivity C-reactive protein (hs-CRP) (median 0.06 mg/L) levels as follows: no NAFLD and hs-CRP
