Clin Rheumatol (2015) 34:1621–1625 DOI 10.1007/s10067-015-3006-y
BRIEF REPORT
Increased IL-35 serum levels in systemic sclerosis and association with pulmonary interstitial involvement Andréa Tavares Dantas 1,2 & Sayonara Maria Calado Gonçalves 1 & Michelly Cristiny Pereira 1 & Rafaela Silva Guimarães Gonçalves 1,2 & Cláudia Diniz Lopes Marques 2 & Moacyr Jesus Barreto de Melo Rego 1 & Ivan da Rocha Pitta 1 & Angela Luzia Branco Pinto Duarte 2 & Maira Galdino da Rocha Pitta 1
Received: 1 February 2015 / Revised: 16 June 2015 / Accepted: 1 July 2015 / Published online: 11 July 2015 # International League of Associations for Rheumatology (ILAR) 2015
Abstract The objective of this study is to assess the serum IL-35 level and its association with clinical manifestations in patients with systemic sclerosis (SSc). IL-35 serum levels were measured by ELISA from 56 patients with SSc and 53 healthy controls. Association of IL-35 serum levels were sought with clinical parameters. Serum IL-35 levels were significantly higher in SSc patients (5.08±0.76 pg/ml) than in healthy individuals (1.89±0.69 pg/ml; p
BRIEF REPORT
Increased IL-35 serum levels in systemic sclerosis and association with pulmonary interstitial involvement Andréa Tavares Dantas 1,2 & Sayonara Maria Calado Gonçalves 1 & Michelly Cristiny Pereira 1 & Rafaela Silva Guimarães Gonçalves 1,2 & Cláudia Diniz Lopes Marques 2 & Moacyr Jesus Barreto de Melo Rego 1 & Ivan da Rocha Pitta 1 & Angela Luzia Branco Pinto Duarte 2 & Maira Galdino da Rocha Pitta 1
Received: 1 February 2015 / Revised: 16 June 2015 / Accepted: 1 July 2015 / Published online: 11 July 2015 # International League of Associations for Rheumatology (ILAR) 2015
Abstract The objective of this study is to assess the serum IL-35 level and its association with clinical manifestations in patients with systemic sclerosis (SSc). IL-35 serum levels were measured by ELISA from 56 patients with SSc and 53 healthy controls. Association of IL-35 serum levels were sought with clinical parameters. Serum IL-35 levels were significantly higher in SSc patients (5.08±0.76 pg/ml) than in healthy individuals (1.89±0.69 pg/ml; p
