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207 [54] μmol/L, and at follow-up, 90 [26] μmol/L) and PEG (nonresponders [n = 2], initial ammonia levels, 74 and 139 μmol/L, and at follow-up, 175 and 125 μmol/L; responders [n = 16], initial mean [SD] ammonia level, 172 [93] μmol/L, and at follow-up, 104 [57] μmol/L). The only statistically significant difference was that baseline ammonia levels were higher in lactulose responders than in nonresponders (P = .04, Spearman rank correlation coefficient). Because ammonia levels do not correlate well with the grade of HE, most practitioners prefer clinical indicators to assess HE.6 Corresponding Authors: Don C. Rockey, MD, Department of Internal Medicine, Medical University of South Carolina, 96 Jonathan Lucas Dr, CSB 803, Charleston, SC 29425 ([email protected]); and Robert S. Rahimi, MD, MS, Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, 3410 Worth St, Ste 860, Dallas, TX 75246 ([email protected]). Conflict of Interest Disclosures: None reported. 1. Rahimi RS, Singal AG, Cuthbert JA, Rockey DC. Lactulose vs polyethylene glycol 3350-electrolyte solution for treatment of overt hepatic encephalopathy: the HELP randomized clinical trial. JAMA Intern Med. 2014;174(11):1727-1733. 2. Munoz SJ. Hepatic encephalopathy. Med Clin North Am. 2008;92(4):795-812. 3. Norenberg MD, Leslie KO, Robertson AS. Association between rise in serum sodium and central pontine myelinolysis. Ann Neurol. 1982;11(2):128-135. 4. Sharma BC, Sharma P, Lunia MK, Srivastava S, Goyal R, Sarin SK. A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy. Am J Gastroenterol. 2013;108(9):1458-1463. 5. Rahimi RS, Elliott AC, Rockey DC. Altered mental status in cirrhosis: etiologies and outcomes. J Investig Med. 2013;61(4):695-700.
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6. Gundling F, Zelihic E, Seidl H, et al. How to diagnose hepatic encephalopathy in the emergency department. Ann Hepatol. 2013;12(1):108-114.
CORRECTION Errors in Intervention Cost per Smoker: In the Original Investigation titled “Proactive Tobacco Cessation Outreach to Smokers of Low Socioeconomic Status: A Randomized Clinical Trial” published in the February 2015 issue of JAMA Internal Medicine (2015;175[2]:218-226. doi:10.1001/jamainternmed.2014.6674), several errors appeared in the statement reporting results of the intervention’s cost-persmoker analysis in the Discussion section. The correct statement is as follows: “For the 8544 registry-identified smokers in our clinics, the design and implementation of this intervention was estimated to cost $283 023 ($33.13 per registryidentified smoker).” This article has been corrected online. Error in Text: In the Original Investigation by Mafi et al titled “Worsening Trends in the Management and Treatment of Back Pain,” published online July 29, 2013, and also in the September 23, 2013, print issue of JAMA Internal Medicine (2013; 173[17]:1573-1581. doi:10.1001/jamainternmed.2013.8992), the odds ratios for Hispanic patients and other race/ethnicity patients were transposed in the second sentence of the last paragraph of the Results section. The sentence should read as follows: “Patients of black, Hispanic, and other race/ethnicity had lower odds ratios (ORs) for receiving narcotic medications (OR, 0.77; 95% CI, 0.65-0.92; OR, 0.51; 95% CI, 0.40-0.65; and OR, 0.60; 95% CI, 0.39-0.95; respectively), as did female patients (OR, 0.86; 95% CI, 0.77-0.96).” This article was corrected online. Incorrect Author Name: In the article titled “Safety and Benefit of Discontinuing Statin Therapy in the Setting of Advanced, Life-Limiting Illness: A Randomized Clinical Trial,” published online March 23, 2015, and also in this issue of JAMA Internal Medicine (doi:10.1001/jamainternmed.2015.0289), an error occurred in the byline. The third author’s name should have been given as Donald H. Taylor Jr, PhD. This article was corrected online and in print.
(Reprinted) JAMA Internal Medicine May 2015 Volume 175, Number 5
Copyright 2015 American Medical Association. All rights reserved.
Downloaded From: by a Uppsala University User on 12/05/2017
869
207 [54] μmol/L, and at follow-up, 90 [26] μmol/L) and PEG (nonresponders [n = 2], initial ammonia levels, 74 and 139 μmol/L, and at follow-up, 175 and 125 μmol/L; responders [n = 16], initial mean [SD] ammonia level, 172 [93] μmol/L, and at follow-up, 104 [57] μmol/L). The only statistically significant difference was that baseline ammonia levels were higher in lactulose responders than in nonresponders (P = .04, Spearman rank correlation coefficient). Because ammonia levels do not correlate well with the grade of HE, most practitioners prefer clinical indicators to assess HE.6 Corresponding Authors: Don C. Rockey, MD, Department of Internal Medicine, Medical University of South Carolina, 96 Jonathan Lucas Dr, CSB 803, Charleston, SC 29425 ([email protected]); and Robert S. Rahimi, MD, MS, Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, 3410 Worth St, Ste 860, Dallas, TX 75246 ([email protected]). Conflict of Interest Disclosures: None reported. 1. Rahimi RS, Singal AG, Cuthbert JA, Rockey DC. Lactulose vs polyethylene glycol 3350-electrolyte solution for treatment of overt hepatic encephalopathy: the HELP randomized clinical trial. JAMA Intern Med. 2014;174(11):1727-1733. 2. Munoz SJ. Hepatic encephalopathy. Med Clin North Am. 2008;92(4):795-812. 3. Norenberg MD, Leslie KO, Robertson AS. Association between rise in serum sodium and central pontine myelinolysis. Ann Neurol. 1982;11(2):128-135. 4. Sharma BC, Sharma P, Lunia MK, Srivastava S, Goyal R, Sarin SK. A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy. Am J Gastroenterol. 2013;108(9):1458-1463. 5. Rahimi RS, Elliott AC, Rockey DC. Altered mental status in cirrhosis: etiologies and outcomes. J Investig Med. 2013;61(4):695-700.
jamainternalmedicine.com
6. Gundling F, Zelihic E, Seidl H, et al. How to diagnose hepatic encephalopathy in the emergency department. Ann Hepatol. 2013;12(1):108-114.
CORRECTION Errors in Intervention Cost per Smoker: In the Original Investigation titled “Proactive Tobacco Cessation Outreach to Smokers of Low Socioeconomic Status: A Randomized Clinical Trial” published in the February 2015 issue of JAMA Internal Medicine (2015;175[2]:218-226. doi:10.1001/jamainternmed.2014.6674), several errors appeared in the statement reporting results of the intervention’s cost-persmoker analysis in the Discussion section. The correct statement is as follows: “For the 8544 registry-identified smokers in our clinics, the design and implementation of this intervention was estimated to cost $283 023 ($33.13 per registryidentified smoker).” This article has been corrected online. Error in Text: In the Original Investigation by Mafi et al titled “Worsening Trends in the Management and Treatment of Back Pain,” published online July 29, 2013, and also in the September 23, 2013, print issue of JAMA Internal Medicine (2013; 173[17]:1573-1581. doi:10.1001/jamainternmed.2013.8992), the odds ratios for Hispanic patients and other race/ethnicity patients were transposed in the second sentence of the last paragraph of the Results section. The sentence should read as follows: “Patients of black, Hispanic, and other race/ethnicity had lower odds ratios (ORs) for receiving narcotic medications (OR, 0.77; 95% CI, 0.65-0.92; OR, 0.51; 95% CI, 0.40-0.65; and OR, 0.60; 95% CI, 0.39-0.95; respectively), as did female patients (OR, 0.86; 95% CI, 0.77-0.96).” This article was corrected online. Incorrect Author Name: In the article titled “Safety and Benefit of Discontinuing Statin Therapy in the Setting of Advanced, Life-Limiting Illness: A Randomized Clinical Trial,” published online March 23, 2015, and also in this issue of JAMA Internal Medicine (doi:10.1001/jamainternmed.2015.0289), an error occurred in the byline. The third author’s name should have been given as Donald H. Taylor Jr, PhD. This article was corrected online and in print.
(Reprinted) JAMA Internal Medicine May 2015 Volume 175, Number 5
Copyright 2015 American Medical Association. All rights reserved.
Downloaded From: by a Uppsala University User on 12/05/2017
869
