RESEARCH ARTICLE
Incidence of Severe Neutropenia in HIVInfected People Starting Antiretroviral Therapy in West Africa Charline Leroi1,2*, Eric Balestre1,2, Eugene Messou3,4, Albert Minga5, Adrien Sawadogo6, Joseph Drabo7, Moussa Maiga8, Marcel Zannou9, Moussa Seydi10, Francois Dabis1,2, Antoine Jaquet1,2, for the IeDEA West Africa collaboration¶
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1 Bordeaux University, School of Public Health (ISPED), Centre INSERM U1219-EpidemiologieBiostatistique, Bordeaux, France, 2 INSERM, ISPED, Centre INSERM U1219-Epidemiologie-Biostatistique, Bordeaux, France, 3 Programme PAC-CI, CHU de Treichville, Abidjan, Coˆte d’Ivoire, 4 Centre de Prise en charge de Recherche et de Formation, Hoˆpital Yopougon Attie´, Abidjan, Coˆte d’Ivoire, 5 Centre Me´dical de Suivi de Donneurs de Sang /CNTS/PRIMO-CI, Abidjan, Cote d’Ivoire, 6 De´partement de maladies infectieuses, CHU Souro Sanou, Bobo-Dioulasso, Burkina Faso, 7 Service de Me´decine interne, CHU Yalgado Ouedraogo (CHU-YO), Ouagadougou, Burkina Faso, 8 Service d’He´pato-Gastro-Ente´rologie, Hoˆpital Gabriel Toure´, Bamako, Mali, 9 Centre de Prise en Charge des Personnes vivant avec le VIH, CNHU, Cotonou, Benin, 10 Service de maladies infectieuses et tropicales, CRCF, CHU de Fann, Dakar, Se´ne´gal ¶ See acknowledgments * [email protected]
OPEN ACCESS Citation: Leroi C, Balestre E, Messou E, Minga A, Sawadogo A, Drabo J, et al. (2017) Incidence of Severe Neutropenia in HIV-Infected People Starting Antiretroviral Therapy in West Africa. PLoS ONE 12(1): e0170753. doi:10.1371/journal. pone.0170753 Editor: Cristian Apetrei, University of Pittsburgh Centre for Vaccine Research, UNITED STATES Received: November 24, 2016
Abstract Background In sub-Saharan Africa, antiretroviral therapy (ART) including drugs with potential toxicity such as Zidovudine (ZDV) are routinely prescribed. This study aimed at estimating the incidence of severe neutropenia and associated factors after ART initiation in five West African countries.
Accepted: December 27, 2016 Published: January 25, 2017
Methods
Copyright: © 2017 Leroi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A retrospective cohort analysis was conducted within the international epidemiologic database to evaluate AIDS (IeDEA) collaboration in West Africa. All HIV-infected adults, initiating ART between 2002 and 2014, with a baseline and at least one follow-up absolute neutrophil count (ANC) measurement were eligible. Incidence of severe neutropenia (ANC
Incidence of Severe Neutropenia in HIVInfected People Starting Antiretroviral Therapy in West Africa Charline Leroi1,2*, Eric Balestre1,2, Eugene Messou3,4, Albert Minga5, Adrien Sawadogo6, Joseph Drabo7, Moussa Maiga8, Marcel Zannou9, Moussa Seydi10, Francois Dabis1,2, Antoine Jaquet1,2, for the IeDEA West Africa collaboration¶
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1 Bordeaux University, School of Public Health (ISPED), Centre INSERM U1219-EpidemiologieBiostatistique, Bordeaux, France, 2 INSERM, ISPED, Centre INSERM U1219-Epidemiologie-Biostatistique, Bordeaux, France, 3 Programme PAC-CI, CHU de Treichville, Abidjan, Coˆte d’Ivoire, 4 Centre de Prise en charge de Recherche et de Formation, Hoˆpital Yopougon Attie´, Abidjan, Coˆte d’Ivoire, 5 Centre Me´dical de Suivi de Donneurs de Sang /CNTS/PRIMO-CI, Abidjan, Cote d’Ivoire, 6 De´partement de maladies infectieuses, CHU Souro Sanou, Bobo-Dioulasso, Burkina Faso, 7 Service de Me´decine interne, CHU Yalgado Ouedraogo (CHU-YO), Ouagadougou, Burkina Faso, 8 Service d’He´pato-Gastro-Ente´rologie, Hoˆpital Gabriel Toure´, Bamako, Mali, 9 Centre de Prise en Charge des Personnes vivant avec le VIH, CNHU, Cotonou, Benin, 10 Service de maladies infectieuses et tropicales, CRCF, CHU de Fann, Dakar, Se´ne´gal ¶ See acknowledgments * [email protected]
OPEN ACCESS Citation: Leroi C, Balestre E, Messou E, Minga A, Sawadogo A, Drabo J, et al. (2017) Incidence of Severe Neutropenia in HIV-Infected People Starting Antiretroviral Therapy in West Africa. PLoS ONE 12(1): e0170753. doi:10.1371/journal. pone.0170753 Editor: Cristian Apetrei, University of Pittsburgh Centre for Vaccine Research, UNITED STATES Received: November 24, 2016
Abstract Background In sub-Saharan Africa, antiretroviral therapy (ART) including drugs with potential toxicity such as Zidovudine (ZDV) are routinely prescribed. This study aimed at estimating the incidence of severe neutropenia and associated factors after ART initiation in five West African countries.
Accepted: December 27, 2016 Published: January 25, 2017
Methods
Copyright: © 2017 Leroi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A retrospective cohort analysis was conducted within the international epidemiologic database to evaluate AIDS (IeDEA) collaboration in West Africa. All HIV-infected adults, initiating ART between 2002 and 2014, with a baseline and at least one follow-up absolute neutrophil count (ANC) measurement were eligible. Incidence of severe neutropenia (ANC
