ARTICLE IN PRESS Cancer Letters ■■ (2015) ■■–■■
Contents lists available at ScienceDirect
Cancer Letters j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / c a n l e t
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Original Articles
Incidence, mortality and survival of childhood cancer in China during 2000–2010 period: A population-based study Rongshou Zheng a,1, Xiaoxia Peng b,c,1, Hongmei Zeng a, Siwei Zhang a, Tianhui Chen d, Q1 Huanmin Wang b,2, Wanqing Chen a,*,2 a National Office for Cancer Prevention and Control, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences, No.17, Pan-Jia-Yuan South Lane, Chaoyang District, Beijing 100021, China b Department of Surgical Oncology, Beijing Children’s Hospital, Capital Medical University, No 56, Li-Shi South Road, Xicheng District, Beijing 1000056, China c Department of Biostatistics and Epidemiology, School of Public Health, Beijing, China d Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580 (TP3), D-69120 Heidelberg, Germany
A R T I C L E
I N F O
Article history: Received 29 January 2015 Received in revised form 18 April 2015 Accepted 20 April 2015 Keywords: Childhood cancer Cancer registry China
A B S T R A C T
The objective of this study is to assess Chinese nationwide incidence, mortality and survival of childhood cancers, which has not been reported. Data from 145 Chinese Cancer Registries, which covered 158,403,248 populations, were pooled for analyses. Cancer patients were diagnosed during 2000–2010 at age 0–14 years. Age-standardized incidence and mortality rates and relative survival rates were calculated. Survival was estimated by the classic cohort approach. New cancer cases were projected using a Bayesian age–period–cohort model. Overall age-standardized incidence was 87.1 per million and agestandardized mortality was 36.3 per million. We found a statistically significant increase in incidence rate annually with 2.8% (95% CI: 1.1–4.6%, p < 0.05), a non-significant decreased mortality, and overall 5-year relative survival reaching 71.9% (95% CI: 69.4–77.1%). Projected new cases in 2015 are 22,875. We provide, for the first time, Chinese nationwide incidence, mortality and their temporal trends, and relative survival rates during the period of 2003–2005 for childhood cancer, which will contribute to a better understanding of the etiology and prevention of childhood cancers. The increasing trend of incidence rate and low 5-year relative survival rate suggest that more efforts for prevention and control of childhood cancers shall be invested in China. © 2015 Published by Elsevier Ireland Ltd.
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Introduction Due to advances in early diagnosis and effective therapy over the past few decades, childhood cancer (diagnosed at age
Contents lists available at ScienceDirect
Cancer Letters j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / c a n l e t
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41
Original Articles
Incidence, mortality and survival of childhood cancer in China during 2000–2010 period: A population-based study Rongshou Zheng a,1, Xiaoxia Peng b,c,1, Hongmei Zeng a, Siwei Zhang a, Tianhui Chen d, Q1 Huanmin Wang b,2, Wanqing Chen a,*,2 a National Office for Cancer Prevention and Control, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences, No.17, Pan-Jia-Yuan South Lane, Chaoyang District, Beijing 100021, China b Department of Surgical Oncology, Beijing Children’s Hospital, Capital Medical University, No 56, Li-Shi South Road, Xicheng District, Beijing 1000056, China c Department of Biostatistics and Epidemiology, School of Public Health, Beijing, China d Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580 (TP3), D-69120 Heidelberg, Germany
A R T I C L E
I N F O
Article history: Received 29 January 2015 Received in revised form 18 April 2015 Accepted 20 April 2015 Keywords: Childhood cancer Cancer registry China
A B S T R A C T
The objective of this study is to assess Chinese nationwide incidence, mortality and survival of childhood cancers, which has not been reported. Data from 145 Chinese Cancer Registries, which covered 158,403,248 populations, were pooled for analyses. Cancer patients were diagnosed during 2000–2010 at age 0–14 years. Age-standardized incidence and mortality rates and relative survival rates were calculated. Survival was estimated by the classic cohort approach. New cancer cases were projected using a Bayesian age–period–cohort model. Overall age-standardized incidence was 87.1 per million and agestandardized mortality was 36.3 per million. We found a statistically significant increase in incidence rate annually with 2.8% (95% CI: 1.1–4.6%, p < 0.05), a non-significant decreased mortality, and overall 5-year relative survival reaching 71.9% (95% CI: 69.4–77.1%). Projected new cases in 2015 are 22,875. We provide, for the first time, Chinese nationwide incidence, mortality and their temporal trends, and relative survival rates during the period of 2003–2005 for childhood cancer, which will contribute to a better understanding of the etiology and prevention of childhood cancers. The increasing trend of incidence rate and low 5-year relative survival rate suggest that more efforts for prevention and control of childhood cancers shall be invested in China. © 2015 Published by Elsevier Ireland Ltd.
42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57
Introduction Due to advances in early diagnosis and effective therapy over the past few decades, childhood cancer (diagnosed at age
