Accepted Article
Incidence and survival in late liver metastases of colorectal cancer 1 Landreau Pierre MD (1), Drouillard Antoine MD (2), Launoy Guy MD PhD (3), Ortega-
Deballon Pablo MD PhD (1), Jooste Valérie PhD (2), Côme Lepage MD PhD (2), Faivre Jean MD PhD (2), Facy Olivier MD PhD (1), Bouvier Anne-Marie MD PhD (2)
(1) Department of Digestive Surgical Oncology. University Hospital of Dijon, France (2) Digestive cancer registry of Burgundy F-21079; INSERM U866; CHU Dijon; University of Burgundy, France (3) Digestive tumour registry of Calvados F-14000, CHU Caen, U1086 INSERM, Cancers and Preventions, France Corresponding author: Anne-Marie Bouvier Digestive Cancer Registry of Burgundy; University Hospital Dijon, F-21079; INSERM U866; University of Burgundy, Dijon BP 87900, 21079 Dijon Cedex France Tel: +33 3 80 39 33 38, Fax: +33 3 80 66 82 51 Email: [email protected]
Abbreviations: HR: hazard ratio, CI: confidence interval
Funding: This project was supported by a grant from the Programme Hospitalier de Recherche Clinique (PHRC10-07-04), France.
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jgh.12685 This article is protected by copyright. All rights reserved.
1
Accepted Article
Abstract: Background & Aims: Data concerning the risk of long term liver metastasis following surgery of colorectal cancer in the general population are scarce. The 10-year incidence and prognosis of metachronous liver metastases remain unknown. Methods: Among 4,584 patients resected for cure for colorectal cancer recorded in two French digestive population-based cancer registries between 1985 and 2000, 602 presented metastases including liver metastases. Results: The cumulated incidence of liver metastasis was 15% at 5 years and 17% at 10 years, and was mainly related to stage at diagnosis. The 10-year cumulative incidence was 6% for stage I and 30% for stage III. The hazard ratio was 3.2 [2.4-4.3] for stage II and 6.9 [5.1-9.2] for stage III compared with stage I. Among survivors with no recurrence five years after diagnosis, 2.2% developed liver metastasis between 5 and 10 years. Resection for cure of liver metastases was performed in 35% of patients aged under 75 years and in 10% of patients over 75 (p
Incidence and survival in late liver metastases of colorectal cancer 1 Landreau Pierre MD (1), Drouillard Antoine MD (2), Launoy Guy MD PhD (3), Ortega-
Deballon Pablo MD PhD (1), Jooste Valérie PhD (2), Côme Lepage MD PhD (2), Faivre Jean MD PhD (2), Facy Olivier MD PhD (1), Bouvier Anne-Marie MD PhD (2)
(1) Department of Digestive Surgical Oncology. University Hospital of Dijon, France (2) Digestive cancer registry of Burgundy F-21079; INSERM U866; CHU Dijon; University of Burgundy, France (3) Digestive tumour registry of Calvados F-14000, CHU Caen, U1086 INSERM, Cancers and Preventions, France Corresponding author: Anne-Marie Bouvier Digestive Cancer Registry of Burgundy; University Hospital Dijon, F-21079; INSERM U866; University of Burgundy, Dijon BP 87900, 21079 Dijon Cedex France Tel: +33 3 80 39 33 38, Fax: +33 3 80 66 82 51 Email: [email protected]
Abbreviations: HR: hazard ratio, CI: confidence interval
Funding: This project was supported by a grant from the Programme Hospitalier de Recherche Clinique (PHRC10-07-04), France.
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jgh.12685 This article is protected by copyright. All rights reserved.
1
Accepted Article
Abstract: Background & Aims: Data concerning the risk of long term liver metastasis following surgery of colorectal cancer in the general population are scarce. The 10-year incidence and prognosis of metachronous liver metastases remain unknown. Methods: Among 4,584 patients resected for cure for colorectal cancer recorded in two French digestive population-based cancer registries between 1985 and 2000, 602 presented metastases including liver metastases. Results: The cumulated incidence of liver metastasis was 15% at 5 years and 17% at 10 years, and was mainly related to stage at diagnosis. The 10-year cumulative incidence was 6% for stage I and 30% for stage III. The hazard ratio was 3.2 [2.4-4.3] for stage II and 6.9 [5.1-9.2] for stage III compared with stage I. Among survivors with no recurrence five years after diagnosis, 2.2% developed liver metastasis between 5 and 10 years. Resection for cure of liver metastases was performed in 35% of patients aged under 75 years and in 10% of patients over 75 (p
