DIAGN MICROBIOLINFECTDIS 1992;15:613-620
613
In vitro Activity of CP-74,667 A N e w Fluoroquinolone Compared with Other Quinolones Jian-Wei Gu, Wei Fang, Nai-Xun Chin, and Harold C. Neu
CP-74,667, a 6-fluoro-7-bridged piperazinyl-l-cyclopropyl-4 quinolone, inhibited 90% of staphylococci, E-hemolytic streptococci, enterococci, Enterobacteriaceae, and Pseudomonas aeruginosa at 16 1->16 1->16
4 >16 >16 >16
8 >16 >16 >16
0.25 0.25 0.06 0.25
2 2 1 2
MethiciUin susceptible
23
Methicillin resistant
Ciprofloxacin resistant
Staphylococcus epidermidis Methicillin susceptible
Agent
29
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.06-2 0.06~t 0.03-1 0.06-2
CP-74,667 in v i t r o A c t i v i t y
TABLE 1
615
Continued MIC (p,g/ml) No.
Organism Methicillin resistant
Enterococcus faecalis
Tested 30
29
Agent CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
Range 0.03-1 O. 12-1 O.03-0.05 O. 12-1
50%
90%
0.12 0.25 0.06 0.12
1 1
0.5 1
2 2
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.06->8 -8 0.03->8 0.06->8
0.5 1 0.25 1
2 4
Streptococcus pneumoniae
30
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.25-4 O.25-4 0.06-0.5 O.25-2
1 1 0.25 0.5
1 4 0.5 1
Streptococcus pyogenes
16
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.12-0.5 0.25-1 O.06-0.25 0.25-1
0.12 0.5 0.12 0.5
0.25 1 0.25 1
Streptococcus agalactiae
13
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.12-1 0.25-4 0.06-2 0.5-4
0.25 1 0.25 1
1 2 1 4
Group C, F, a n d G streptococci
28
CP-74, 667
0.12-1
0.25
0.5
Ciprofloxacin Tosufloxacin Temafloxacin
0.25-4 0.06-2 0.25-4
1 0.25 !
2 0.5 4
Listeria monocytogenes
15
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.25-1 0.25-1 0.12-0.5 0.25-4
0.5 1 0.25 1
1 1 0.5 2
Corynebacterium jeikeium
15
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.12-1 0.5--4 0.12-0.5 0.25-1
0.5 1 0.5 1
1 4 0.5 2
Bacteroides fragilis
12
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.5-4 2-16 0.25-2 1-4
1 4 1 1
2 16 2 2
Bacteroides spp.
13
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.06-4 2-16 0.12-4 1-4
2 8 1 2
4 16 2 4
Clostridium spp.
18
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.06-2 0.06-1 0.03-0.25
0.06-1
0.5 0.25 0.12 0.25
2 1 0.25 0.5
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.5-2 0.5-2 0.12-0.25 O. 12-1
1 0.5 0.25 0.5
Peptostreptococcus spp.
8
616
TABLE 1
J.-W. Gu et al.
Continued MIC 0xg/ml)
Orgamsm
No. Tesled
Agent
Range
:~0%
90%
blaemophilus influenzae
18
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.015-0.5 0.015-5 0.015-0.25 0.015-1
0.06 0.015 0.015 0.015
0.25 0.12 0.12 0.25
Moraxella catarrhalis
31
CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin
0.06-0.25 0.03-0.06 0.015-0.03 0.015-0.06
0.12 0.03 0.015 0.06
0.25 0.06 0.03 0.06
Escherichia coli
31
CP-74, 667 Ciprofloxacm Tosufloxacin Temafloxacin
-