DIAGN MICROBIOLINFECTDIS 1992;15:613-620

613

In vitro Activity of CP-74,667 A N e w Fluoroquinolone Compared with Other Quinolones Jian-Wei Gu, Wei Fang, Nai-Xun Chin, and Harold C. Neu

CP-74,667, a 6-fluoro-7-bridged piperazinyl-l-cyclopropyl-4 quinolone, inhibited 90% of staphylococci, E-hemolytic streptococci, enterococci, Enterobacteriaceae, and Pseudomonas aeruginosa at 16 1->16 1->16

4 >16 >16 >16

8 >16 >16 >16

0.25 0.25 0.06 0.25

2 2 1 2

MethiciUin susceptible

23

Methicillin resistant

Ciprofloxacin resistant

Staphylococcus epidermidis Methicillin susceptible

Agent

29

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.06-2 0.06~t 0.03-1 0.06-2

CP-74,667 in v i t r o A c t i v i t y

TABLE 1

615

Continued MIC (p,g/ml) No.

Organism Methicillin resistant

Enterococcus faecalis

Tested 30

29

Agent CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

Range 0.03-1 O. 12-1 O.03-0.05 O. 12-1

50%

90%

0.12 0.25 0.06 0.12

1 1

0.5 1

2 2

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.06->8 -8 0.03->8 0.06->8

0.5 1 0.25 1

2 4

Streptococcus pneumoniae

30

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.25-4 O.25-4 0.06-0.5 O.25-2

1 1 0.25 0.5

1 4 0.5 1

Streptococcus pyogenes

16

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.12-0.5 0.25-1 O.06-0.25 0.25-1

0.12 0.5 0.12 0.5

0.25 1 0.25 1

Streptococcus agalactiae

13

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.12-1 0.25-4 0.06-2 0.5-4

0.25 1 0.25 1

1 2 1 4

Group C, F, a n d G streptococci

28

CP-74, 667

0.12-1

0.25

0.5

Ciprofloxacin Tosufloxacin Temafloxacin

0.25-4 0.06-2 0.25-4

1 0.25 !

2 0.5 4

Listeria monocytogenes

15

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.25-1 0.25-1 0.12-0.5 0.25-4

0.5 1 0.25 1

1 1 0.5 2

Corynebacterium jeikeium

15

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.12-1 0.5--4 0.12-0.5 0.25-1

0.5 1 0.5 1

1 4 0.5 2

Bacteroides fragilis

12

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.5-4 2-16 0.25-2 1-4

1 4 1 1

2 16 2 2

Bacteroides spp.

13

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.06-4 2-16 0.12-4 1-4

2 8 1 2

4 16 2 4

Clostridium spp.

18

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.06-2 0.06-1 0.03-0.25

0.06-1

0.5 0.25 0.12 0.25

2 1 0.25 0.5

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.5-2 0.5-2 0.12-0.25 O. 12-1

1 0.5 0.25 0.5

Peptostreptococcus spp.

8

616

TABLE 1

J.-W. Gu et al.

Continued MIC 0xg/ml)

Orgamsm

No. Tesled

Agent

Range

:~0%

90%

blaemophilus influenzae

18

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.015-0.5 0.015-5 0.015-0.25 0.015-1

0.06 0.015 0.015 0.015

0.25 0.12 0.12 0.25

Moraxella catarrhalis

31

CP-74, 667 Ciprofloxacin Tosufloxacin Temafloxacin

0.06-0.25 0.03-0.06 0.015-0.03 0.015-0.06

0.12 0.03 0.015 0.06

0.25 0.06 0.03 0.06

Escherichia coli

31

CP-74, 667 Ciprofloxacm Tosufloxacin Temafloxacin

-

In vitro activity of CP-74,667. A new fluoroquinolone compared with other quinolones.

CP-74,667, a 6-fluoro-7-bridged piperazinyl-1-cyclopropyl-4 quinolone, inhibited 90% of staphylococci, beta-hemolytic streptococci, enterococci, Enter...
523KB Sizes 0 Downloads 0 Views