Title
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Prognostic effect of inflammatory lymphadenopathies in renal cell carcinoma patients treated with nephrectomy and extended lymph node dissection Eur Urol Suppl 2015;14/2;e311
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Capitanio U., Di Trapani E., Matloob R., Freschi M., Capogrosso P., Carenzi C., Salonia A., Dell'Oglio P., Briganti A., Gallina A., Montorsi F., Bertini R. San Raffaele Scientific Institute, Dept. of Urology, Milan, Italy INTRODUCTION & OBJECTIVES: In more than half of renal cell carcinoma (RCC) patients with lymphadenopathies at diagnosis (cN1), final pathological examination does not confirm the presence of lymph node invasion (LNI) after surgery. In this context, no study has ever address whether the suspicion of LNI at imaging (cN1 cases) affects RCC specific survival (CSS) if the pathological examination does not confirm lymph node invasion (pN0). MATERIAL & METHODS: Between 1987 and 2012, 1983 RCC patients underwent either partial or radical nephrectomy at a single tertiary care institution. For the aim of the study, only patients submitted to a systematic lymphadenectomy and without pathologically confirmed nodal invasion (pN0) cases were included. Cox regression analyses assessed the effect of clinical nodal status on CSS. Multi-variable analyses were adjusted for age, pathological stage, tumour size, Fuhrman grade, presence of coagulative necrosis, sarcomatoid features and presence of metastases. RESULTS: Among 760 pN0 RCC cases, 93 patients (12.2%) had a preoperative suspicion of nodal invasion at imaging (cN1). Mean age was 61.2 vs. 60.3 in cN1 and cN0, respectively (p=0.5). Mean tumour diameter was 8.6 vs. 7.0 cm in cN1 and cN0, respectively (p=0.001). Pathological T stage resulted pT1, pT2, pT3 and pT4 in 22.0 vs. 45.0%, 16.5 vs. 18.0%, 58.2% vs. 34.5% and 3.3 vs. 2.5% of cN1 and cN0 cases, respectively (p
311
Prognostic effect of inflammatory lymphadenopathies in renal cell carcinoma patients treated with nephrectomy and extended lymph node dissection Eur Urol Suppl 2015;14/2;e311
Print! Print!
Capitanio U., Di Trapani E., Matloob R., Freschi M., Capogrosso P., Carenzi C., Salonia A., Dell'Oglio P., Briganti A., Gallina A., Montorsi F., Bertini R. San Raffaele Scientific Institute, Dept. of Urology, Milan, Italy INTRODUCTION & OBJECTIVES: In more than half of renal cell carcinoma (RCC) patients with lymphadenopathies at diagnosis (cN1), final pathological examination does not confirm the presence of lymph node invasion (LNI) after surgery. In this context, no study has ever address whether the suspicion of LNI at imaging (cN1 cases) affects RCC specific survival (CSS) if the pathological examination does not confirm lymph node invasion (pN0). MATERIAL & METHODS: Between 1987 and 2012, 1983 RCC patients underwent either partial or radical nephrectomy at a single tertiary care institution. For the aim of the study, only patients submitted to a systematic lymphadenectomy and without pathologically confirmed nodal invasion (pN0) cases were included. Cox regression analyses assessed the effect of clinical nodal status on CSS. Multi-variable analyses were adjusted for age, pathological stage, tumour size, Fuhrman grade, presence of coagulative necrosis, sarcomatoid features and presence of metastases. RESULTS: Among 760 pN0 RCC cases, 93 patients (12.2%) had a preoperative suspicion of nodal invasion at imaging (cN1). Mean age was 61.2 vs. 60.3 in cN1 and cN0, respectively (p=0.5). Mean tumour diameter was 8.6 vs. 7.0 cm in cN1 and cN0, respectively (p=0.001). Pathological T stage resulted pT1, pT2, pT3 and pT4 in 22.0 vs. 45.0%, 16.5 vs. 18.0%, 58.2% vs. 34.5% and 3.3 vs. 2.5% of cN1 and cN0 cases, respectively (p
