Author's Accepted Manuscript
The Impact of Atrial Fibrillation Termination Mode during Catheter Ablation Procedure on Maintenance of Sinus Rhythm Massimiliano Faustino MD, Carmine Pizzi MD, Donato Capuzzi MD, Tullio Agricola MD, Grazia Maria Costa MD, Maria Elena Flacco MD, Carolina Marzuillo MD, Manuela Nocciolini MD, Lorenzo Capasso MD, Lamberto Manzoli MD, PhD www.elsevier.com/locate/buildenv
PII: DOI: Reference:
S1547-5271(14)00556-6 http://dx.doi.org/10.1016/j.hrthm.2014.05.025 HRTHM5788
To appear in:
Heart Rhythm
Cite this article as: Massimiliano Faustino MD, Carmine Pizzi MD, Donato Capuzzi MD, Tullio Agricola MD, Grazia Maria Costa MD, Maria Elena Flacco MD, Carolina Marzuillo MD, Manuela Nocciolini MD, Lorenzo Capasso MD, Lamberto Manzoli MD, PhD, The Impact of Atrial Fibrillation Termination Mode during Catheter Ablation Procedure on Maintenance of Sinus Rhythm, Heart Rhythm, http://dx.doi.org/10.1016/j. hrthm.2014.05.025 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Title: The impact of atrial fibrillation termination mode during catheter ablation procedure on maintenance of sinus rhythm.
Running title: Efficacy of atrial fibrillation termination modes.
Authors: Massimiliano Faustino, MD (1)*, Carmine Pizzi (2) , MD *; Donato Capuzzi, MD (1), Tullio Agricola, MD (3), Grazia Maria Costa, MD (2), Maria Elena Flacco, MD (4,5), Carolina Marzuillo , MD (6), Manuela Nocciolini, MD (4), Lorenzo Capasso , MD (4,7), Lamberto Manzoli , MD, PhD, (4,5,7).
Affiliations: (1) Cardiology Department, Private Hospital “L. Pierangeli”, Pescara, Italy (2) Department of Specialised, Experimental and Diagnostic Medicine, University of Bologna, Italy;
(3) Electrophysiology
Operating Unit, Cardiovascular Department, “Spirito Santo” Hospital, ASL Pescara, Pescara, Italy;
(4)
Department of Medicine and Aging Sciences, University of Chieti, Italy; (5) Regional Healthcare Agency of Abruzzo, Italy; (6) Sapienza University of Rome, Italy; (7) CeSI Biotech, Chieti, Italy.
Corresponding author: Carmine Pizzi, FESC; Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale (Padiglione 11), Università di Bologna, Via Giuseppe Massarenti 9, 40138 Bologna, Italy. Tel. +39 051 6364911; Fax +39 051 392486; e-mail [email protected] .
* These authors equally contributed to this paper.
Total word count: 5936
Disclosures All authors declare no potential conflicts of interest.
1
Abstract Background: Catheter ablation is a common and effective procedure to address atrial fibrillation (AF) refractory to antiarrhythmic drugs. AF can be terminated directly into sinus rhythm (SR); evolving into regular atrial tachycardia (AT) and subsequently into SR; after direct current (DC) cardioversion if AF persists. Scarce data are available on the relationship between clinical outcomes and termination mode after one catheter ablation. Objectives: We evaluated for the first time the association between 1-year ablation efficacy and termination mode after repeated catheter ablations in patients presenting with persistent or long-standing persistent AF. Methods: This prospective study involved 400 consecutive patients (62.7±7.2y) who underwent catheter ablation for drug-refractory persistent AF (4.6±2.4 months) using a stepwise ablation approach. Results: AF was terminated by radiofrequency application directly into SR in 135 patients; passing through AT into SR in 195 patients; through DC cardioversion in 70 patients. After 1 year of follow-up with repeated Holter monitoring, the percentages of SR maintenance were, respectively, 72.6%, 80.0% and 28.6% (p
The Impact of Atrial Fibrillation Termination Mode during Catheter Ablation Procedure on Maintenance of Sinus Rhythm Massimiliano Faustino MD, Carmine Pizzi MD, Donato Capuzzi MD, Tullio Agricola MD, Grazia Maria Costa MD, Maria Elena Flacco MD, Carolina Marzuillo MD, Manuela Nocciolini MD, Lorenzo Capasso MD, Lamberto Manzoli MD, PhD www.elsevier.com/locate/buildenv
PII: DOI: Reference:
S1547-5271(14)00556-6 http://dx.doi.org/10.1016/j.hrthm.2014.05.025 HRTHM5788
To appear in:
Heart Rhythm
Cite this article as: Massimiliano Faustino MD, Carmine Pizzi MD, Donato Capuzzi MD, Tullio Agricola MD, Grazia Maria Costa MD, Maria Elena Flacco MD, Carolina Marzuillo MD, Manuela Nocciolini MD, Lorenzo Capasso MD, Lamberto Manzoli MD, PhD, The Impact of Atrial Fibrillation Termination Mode during Catheter Ablation Procedure on Maintenance of Sinus Rhythm, Heart Rhythm, http://dx.doi.org/10.1016/j. hrthm.2014.05.025 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Title: The impact of atrial fibrillation termination mode during catheter ablation procedure on maintenance of sinus rhythm.
Running title: Efficacy of atrial fibrillation termination modes.
Authors: Massimiliano Faustino, MD (1)*, Carmine Pizzi (2) , MD *; Donato Capuzzi, MD (1), Tullio Agricola, MD (3), Grazia Maria Costa, MD (2), Maria Elena Flacco, MD (4,5), Carolina Marzuillo , MD (6), Manuela Nocciolini, MD (4), Lorenzo Capasso , MD (4,7), Lamberto Manzoli , MD, PhD, (4,5,7).
Affiliations: (1) Cardiology Department, Private Hospital “L. Pierangeli”, Pescara, Italy (2) Department of Specialised, Experimental and Diagnostic Medicine, University of Bologna, Italy;
(3) Electrophysiology
Operating Unit, Cardiovascular Department, “Spirito Santo” Hospital, ASL Pescara, Pescara, Italy;
(4)
Department of Medicine and Aging Sciences, University of Chieti, Italy; (5) Regional Healthcare Agency of Abruzzo, Italy; (6) Sapienza University of Rome, Italy; (7) CeSI Biotech, Chieti, Italy.
Corresponding author: Carmine Pizzi, FESC; Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale (Padiglione 11), Università di Bologna, Via Giuseppe Massarenti 9, 40138 Bologna, Italy. Tel. +39 051 6364911; Fax +39 051 392486; e-mail [email protected] .
* These authors equally contributed to this paper.
Total word count: 5936
Disclosures All authors declare no potential conflicts of interest.
1
Abstract Background: Catheter ablation is a common and effective procedure to address atrial fibrillation (AF) refractory to antiarrhythmic drugs. AF can be terminated directly into sinus rhythm (SR); evolving into regular atrial tachycardia (AT) and subsequently into SR; after direct current (DC) cardioversion if AF persists. Scarce data are available on the relationship between clinical outcomes and termination mode after one catheter ablation. Objectives: We evaluated for the first time the association between 1-year ablation efficacy and termination mode after repeated catheter ablations in patients presenting with persistent or long-standing persistent AF. Methods: This prospective study involved 400 consecutive patients (62.7±7.2y) who underwent catheter ablation for drug-refractory persistent AF (4.6±2.4 months) using a stepwise ablation approach. Results: AF was terminated by radiofrequency application directly into SR in 135 patients; passing through AT into SR in 195 patients; through DC cardioversion in 70 patients. After 1 year of follow-up with repeated Holter monitoring, the percentages of SR maintenance were, respectively, 72.6%, 80.0% and 28.6% (p
