Author's Accepted Manuscript
Impact Of Adult Congenital Heart Disease (Achd) On Survival And Mortality After Heart Transplantation (Htx) LJ Burchill MBBS PhD, LB Edwards PhD, AI Dipchand MD, J Stehlik MD MPH, HJ Ross MD MHSc
http://www.jhltonline.org
PII: DOI: Reference:
S1053-2498(14)01144-9 http://dx.doi.org/10.1016/j.healun.2014.05.007 HEALUN5777
To appear in:
J Heart Lung Transplant
Cite this article as: LJ Burchill MBBS PhD, LB Edwards PhD, AI Dipchand MD, J Stehlik MD MPH, HJ Ross MD MHSc, Impact Of Adult Congenital Heart Disease (Achd) On Survival And Mortality After Heart Transplantation (Htx), J Heart Lung Transplant, http://dx.doi.org/10.1016/j.healun.2014.05.007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
IMPACT OF ADULT CONGENITAL HEART DISEASE (ACHD) ON SURVIVAL AND MORTALITY AFTER HEART TRANSPLANTATION (HTx). Burchill LJ1, Edwards LB3,6, Dipchand AI4,6, Stehlik J5,6, Ross HJ2.
1. Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon 2. Toronto Congenital Cardiac Centre for Adults, Division of Cardiology, University Health Network, Toronto, Canada. 3. United Network for Organ Sharing, Richmond, Virginia, USA. 4. Hospital for Sick Children, Toronto, Ontario, Canada. 5. University of Utah, Salt Lake City, Utah, USA. 6. ISHLT International Registry for Heart and Lung Transplantation.
Address for Correspondence: Heather J Ross MD MHSc, Heart failure and Transplantation Program, Toronto General Hospital, NCSB 11C, 1203; 585 University Avenue, Toronto, Ontario, Canada, M5G 2N2. Tel: (416) 340 4800 X3482. Fax: (416) 340 4134 Email:[email protected]
Acknowledgments: Dr Luke Burchill is a recipient of the Beth Medjuck Clinical Research Fellowship. Key words: Adult congenital heart disease, Heart failure, Heart transplantation, Word count: 2991 words (excludes tables, figures and references)
Author qualifications and affiliations
Dr Luke J. Burchill MBBS PhD Knight Cardiovascular Institute Oregon Health and Science University Portland, Oregon
Dr Leah B. Edwards PhD United Network for Organ Sharing Richmond, Virginia, USA.
Dr Anne I. Dipchand MD Hospital for Sick Children Toronto, Ontario, Canada.
Dr Joseph Stehlik MD MPH University of Utah University of Utah School of Medicine Salt Lake City, Utah USA.
Dr Heather J. Ross MD MHSc (corresponding author) Heart Failure and Transplantation Program Toronto General Hospital, University Health Network Ontario, Canada.
ABSTRACT Background: Reduced early survival has been reported in ACHD HTx recipients, but little is known about late outcomes after HTx. The aim of this study was to examine survival, causes of death, and predictors of early (5 years) mortality in adult congenital heart disease (ACHD) heart transplant (HTx) recipients. Methods: ACHD patients undergoing HTx between 1985 and 2010 were identified in the Transplant Registry of the International Society for Heart and Lung Transplantation (ISHLT). Survival was compared between ACHD and other adult HTx recipients (‘Controls’) using the Kaplan-Meier method. Factors associated with survival beyond 1 year were assessed using multivariable proportional hazards regression analysis. Results: Of 85,647 adults who underwent HTx, 1851 (2.2%) were transplanted for ACHD. Early death secondary to technical reasons was high among ACHD HTx recipients - 10% vs. 4% in Controls, p
Impact Of Adult Congenital Heart Disease (Achd) On Survival And Mortality After Heart Transplantation (Htx) LJ Burchill MBBS PhD, LB Edwards PhD, AI Dipchand MD, J Stehlik MD MPH, HJ Ross MD MHSc
http://www.jhltonline.org
PII: DOI: Reference:
S1053-2498(14)01144-9 http://dx.doi.org/10.1016/j.healun.2014.05.007 HEALUN5777
To appear in:
J Heart Lung Transplant
Cite this article as: LJ Burchill MBBS PhD, LB Edwards PhD, AI Dipchand MD, J Stehlik MD MPH, HJ Ross MD MHSc, Impact Of Adult Congenital Heart Disease (Achd) On Survival And Mortality After Heart Transplantation (Htx), J Heart Lung Transplant, http://dx.doi.org/10.1016/j.healun.2014.05.007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
IMPACT OF ADULT CONGENITAL HEART DISEASE (ACHD) ON SURVIVAL AND MORTALITY AFTER HEART TRANSPLANTATION (HTx). Burchill LJ1, Edwards LB3,6, Dipchand AI4,6, Stehlik J5,6, Ross HJ2.
1. Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon 2. Toronto Congenital Cardiac Centre for Adults, Division of Cardiology, University Health Network, Toronto, Canada. 3. United Network for Organ Sharing, Richmond, Virginia, USA. 4. Hospital for Sick Children, Toronto, Ontario, Canada. 5. University of Utah, Salt Lake City, Utah, USA. 6. ISHLT International Registry for Heart and Lung Transplantation.
Address for Correspondence: Heather J Ross MD MHSc, Heart failure and Transplantation Program, Toronto General Hospital, NCSB 11C, 1203; 585 University Avenue, Toronto, Ontario, Canada, M5G 2N2. Tel: (416) 340 4800 X3482. Fax: (416) 340 4134 Email:[email protected]
Acknowledgments: Dr Luke Burchill is a recipient of the Beth Medjuck Clinical Research Fellowship. Key words: Adult congenital heart disease, Heart failure, Heart transplantation, Word count: 2991 words (excludes tables, figures and references)
Author qualifications and affiliations
Dr Luke J. Burchill MBBS PhD Knight Cardiovascular Institute Oregon Health and Science University Portland, Oregon
Dr Leah B. Edwards PhD United Network for Organ Sharing Richmond, Virginia, USA.
Dr Anne I. Dipchand MD Hospital for Sick Children Toronto, Ontario, Canada.
Dr Joseph Stehlik MD MPH University of Utah University of Utah School of Medicine Salt Lake City, Utah USA.
Dr Heather J. Ross MD MHSc (corresponding author) Heart Failure and Transplantation Program Toronto General Hospital, University Health Network Ontario, Canada.
ABSTRACT Background: Reduced early survival has been reported in ACHD HTx recipients, but little is known about late outcomes after HTx. The aim of this study was to examine survival, causes of death, and predictors of early (5 years) mortality in adult congenital heart disease (ACHD) heart transplant (HTx) recipients. Methods: ACHD patients undergoing HTx between 1985 and 2010 were identified in the Transplant Registry of the International Society for Heart and Lung Transplantation (ISHLT). Survival was compared between ACHD and other adult HTx recipients (‘Controls’) using the Kaplan-Meier method. Factors associated with survival beyond 1 year were assessed using multivariable proportional hazards regression analysis. Results: Of 85,647 adults who underwent HTx, 1851 (2.2%) were transplanted for ACHD. Early death secondary to technical reasons was high among ACHD HTx recipients - 10% vs. 4% in Controls, p
