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J Natl Compr Canc Netw. Author manuscript; available in PMC 2015 July 01. Published in final edited form as: J Natl Compr Canc Netw. 2014 July ; 12(7): 993–998.

Impact of a Clinical Trial Initiative on Clinical Trial Enrollment in a Multidisciplinary Prostate Cancer Clinic Lydia T. Madsen, RN, M.S.N.1, Deborah A. Kuban, M.D.2, Seungtaek Choi, M.D2, John W. Davis, M.D.3, Jeri Kim, M.D.1, Andrew K. Lee, MD, M.P.H.2, Delora Domain, M.S., Larry Levy, M.S.2, Louis L. Pisters, M.D.3, Curtis A. Pettaway, M.D.3, John F. Ward, M.D.3, Christopher Logothetis, M.D.1, and Karen E. Hoffman, M.D., M.P.H.2

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1Department

of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

2Department

of Radiation Oncology, The University of Texas MD Anderson Cancer Center,

Houston, TX 3Department

of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX

Abstract

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Purpose—Clinical oncology trials are hampered by low accrual rates with less than 5% of adult cancer patients treated on study. We evaluated clinical trial enrollment in our Multidisciplinary Prostate Cancer Clinic (MPCC) to assess if a clinical trial initiative, introduced in 2006, impacted enrollment. Methods—The trial initiative included posting trial specific information in clinic, educating patients about appropriate clinical trial options during the treatment recommendation discussion, and providing patients with trial specific educational information. We evaluated frequency of clinical trial enrollment for men with newly-diagnosed prostate cancer seen in the MPCC from 2004 to 2008. Logistic regression evaluated the impact of patient characteristics and the clinical trial initiative on trial enrollment.

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Results—The median age of the 1,370 men was 64 years. 32% had low-risk, 49% had intermediate-risk and 19% had high-risk disease. Overall, 74% enrolled in at least one trial and 29% enrolled in more than one trial. Trial enrollment increased from 39% before the initiative (127/326) to 84% (880/1044) after the trial initiative. Patient enrollment increased in laboratory studies (25% to 80%), quality-of-life studies (10% to 26%) and studies evaluating investigational treatments and systemic agents (6% to 15%) after the trial initiative. In multivariate analysis, younger men (p

Impact of a clinical trial initiative on clinical trial enrollment in a multidisciplinary prostate cancer clinic.

Clinical oncology trials are hampered by low accrual rates, with fewer than 5% of adult patients with cancer treated on study. Clinical trial enrollme...
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