Wageningen Academic P u b l i s h e r s

Beneficial Microbes, 2016; 7(3): 397-407

http://www.wageningenacademic.com/doi/pdf/10.3920/BM2015.0119 - Friday, September 22, 2017 7:38:52 AM - Göteborgs Universitet IP Address:130.241.16.16

Immunological mechanisms involved in probiotic-mediated protection against Citrobacter rodentium-induced colitis Y. Jiang1#, G. Yang1#, F. Meng2, W. Yang1, J. Hu1, L. Ye1, C. Shi1 and C. Wang1* 1College of Animal Science and Technology, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China

P.R.; 2Guangxi Veterinary Research Institute, 51 Aibei Road, Xixiangtang, Nanning, Guangxi, 530001, China P.R.; # These authors contributed equally to this work; [email protected] Received: 26 August 2015 / Accepted: 10 November 2015 © 2016 Wageningen Academic Publishers

RESEARCH ARTICLE Abstract Inflammatory bowel disease is a group of chronic, incurable inflammatory disorders of the gastrointestinal tract that cause severe diarrhoea, intestinal inflammation, pain, fatigue and weight loss. In this study, we first developed a model of Citrobacter rodentium-induced colitis and then evaluated the protective effects of selected probiotics on inflammation. The results showed that administration of a combination of probiotics including Lactobacillus rhamnosus ATCC 53103, Lactobacillus acidophilus ATCC 4356 and Lactobacillus plantarum A significantly increased the production of CD11c+ dendritic cells in the spleen (3.62% vs phosphate buffered saline (PBS)-treated control, P

Immunological mechanisms involved in probiotic-mediated protection against Citrobacter rodentium-induced colitis.

Inflammatory bowel disease is a group of chronic, incurable inflammatory disorders of the gastrointestinal tract that cause severe diarrhoea, intestin...
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