Original Article
http://dx.doi.org/10.3349/ymj.2015.56.1.82 pISSN: 0513-5796, eISSN: 1976-2437
Yonsei Med J 56(1):82-88, 2015
Immunohistochemical Detection of p53 Expression in Patients with Preoperative Chemoradiation for Rectal Cancer: Association with Prognosis Jung Wook Huh,1 Woo Yong Lee,1 Seok Hyung Kim,2 Yoon Ah Park,1 Yong Beom Cho,1 Seong Hyeon Yun,1 Hee Cheol Kim,1 Hee Chul Park,3 Doo Ho Choi,3 Joon Oh Park,4 Young Suk Park,4 and Ho-Kyung Chun5 Departments of 1Surgery, 2Pathology, 3Radiation Oncology, and 4Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; 5 Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. Received: February 28, 2014 Revised: April 8, 2014 Accepted: April 16, 2014 Corresponding author: Dr. Woo Yong Lee, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. Tel: 82-2-3410-0261, Fax: 82-2-3410-6980 E-mail: [email protected] ∙ The authors have no financial conflicts of interest.
Purpose: The expression of p53 in patients with rectal cancer who underwent preoperative chemoradiationand and its potential prognostic significance were evaluated. Materials and Methods: p53 expression was examined using immunohistochemistry in pathologic specimens from 210 rectal cancer patients with preoperative chemoradiotherapy and radical surgery. All patients were classified into two groups according to the p53 expression: low p53 (
http://dx.doi.org/10.3349/ymj.2015.56.1.82 pISSN: 0513-5796, eISSN: 1976-2437
Yonsei Med J 56(1):82-88, 2015
Immunohistochemical Detection of p53 Expression in Patients with Preoperative Chemoradiation for Rectal Cancer: Association with Prognosis Jung Wook Huh,1 Woo Yong Lee,1 Seok Hyung Kim,2 Yoon Ah Park,1 Yong Beom Cho,1 Seong Hyeon Yun,1 Hee Cheol Kim,1 Hee Chul Park,3 Doo Ho Choi,3 Joon Oh Park,4 Young Suk Park,4 and Ho-Kyung Chun5 Departments of 1Surgery, 2Pathology, 3Radiation Oncology, and 4Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; 5 Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. Received: February 28, 2014 Revised: April 8, 2014 Accepted: April 16, 2014 Corresponding author: Dr. Woo Yong Lee, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. Tel: 82-2-3410-0261, Fax: 82-2-3410-6980 E-mail: [email protected] ∙ The authors have no financial conflicts of interest.
Purpose: The expression of p53 in patients with rectal cancer who underwent preoperative chemoradiationand and its potential prognostic significance were evaluated. Materials and Methods: p53 expression was examined using immunohistochemistry in pathologic specimens from 210 rectal cancer patients with preoperative chemoradiotherapy and radical surgery. All patients were classified into two groups according to the p53 expression: low p53 (
