Hindawi Publishing Corporation Mediators of Inflammation Volume 2014, Article ID 192594, 8 pages http://dx.doi.org/10.1155/2014/192594
Research Article Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis Alessandra D’Abramo, Maria Antonella Zingaropoli, Alessandra Oliva, Claudia D’Agostino, Samir Al Moghazi, Giulia De Luca, Marco Iannetta, Claudio Maria Mastroianni, and Vincenzo Vullo Department of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy Correspondence should be addressed to Alessandra D’Abramo; [email protected] Received 26 June 2014; Revised 13 September 2014; Accepted 14 September 2014; Published 14 October 2014 Academic Editor: Fulvio D’Acquisto Copyright © 2014 Alessandra D’Abramo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. HIV-infected patients have a significantly greater risk of cardiovascular disease. Several markers including osteoprotegerin have been shown to be involved in the development and progression of atherosclerosis. We investigated the relationship between Tcell phenotype, osteoprotegerin, and atherosclerosis evaluated by carotid intima-media thickness (c-IMT) in 94 HIV+ patients on suppressive antiretroviral therapy with Framingham score
Research Article Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis Alessandra D’Abramo, Maria Antonella Zingaropoli, Alessandra Oliva, Claudia D’Agostino, Samir Al Moghazi, Giulia De Luca, Marco Iannetta, Claudio Maria Mastroianni, and Vincenzo Vullo Department of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy Correspondence should be addressed to Alessandra D’Abramo; [email protected] Received 26 June 2014; Revised 13 September 2014; Accepted 14 September 2014; Published 14 October 2014 Academic Editor: Fulvio D’Acquisto Copyright © 2014 Alessandra D’Abramo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. HIV-infected patients have a significantly greater risk of cardiovascular disease. Several markers including osteoprotegerin have been shown to be involved in the development and progression of atherosclerosis. We investigated the relationship between Tcell phenotype, osteoprotegerin, and atherosclerosis evaluated by carotid intima-media thickness (c-IMT) in 94 HIV+ patients on suppressive antiretroviral therapy with Framingham score
