Epilepsy & Behavior 44 (2015) 253–257

Contents lists available at ScienceDirect

Epilepsy & Behavior journal homepage: www.elsevier.com/locate/yebeh

Ictal body turning in focal epilepsy Metin Mercan a,⁎, İrem Yıldırım a, Özgür Akdemir b, Erhan Bilir a a b

Gazi University Faculty of Medicine, Department of Neurology, Ankara, Turkey Gazi University Faculty of Medicine, Department of Nuclear Medicine, Ankara, Turkey

a r t i c l e

i n f o

Article history: Received 29 July 2014 Revised 6 November 2014 Accepted 8 November 2014 Available online 10 March 2015 Keywords: Body turning Head turning Temporal lobe epilepsy

a b s t r a c t Despite the explanations of many lateralization findings, body turning in focal epilepsy has been rarely investigated. One of the aims of this study was to evaluate the role of ictal body turning in the lateralization of focal epilepsies. The records of 263 patients with focal epilepsy (temporal lobe epilepsy (TLE), n = 178; extratemporal lobe epilepsy (ETLE), n = 85) who underwent prolonged video-EEG monitoring during presurgical epilepsy evaluation were reviewed. Preoperative findings (TLE, n = 16; ETLE, n = 6) and postoperative outcomes (TLE, n = 7) of patients with focal epilepsy with ictal body turning were assessed. For the evaluation of ictal body turning, two definitions were proposed. Nonversive body turning (NVBT) was used to denote at least a 90° nonforced (without tonic or clonic component) rotation of the upper (shoulder) and lower (hip) parts of the body around the body axis for a minimum of 3 s. Versive body turning (VBT) was used to denote at least a 90° forced (with tonic or clonic component) rotation of the upper (shoulder) and lower (hip) parts of the body around the body axis for a minimum of 3 s. Nonversive body turning was observed in 6% (n = 11) of patients with TLE and 2% (n = 2) of patients with ETLE. For VBT, these ratios were 5% (n = 8) and 7% (n = 6) for patients with TLE and ETLE, respectively. Nonversive body turning was frequently oriented to the same side as the epileptogenic zone (EZ) in TLE and ETLE seizures (76% and 80%, respectively). If the amount of NVBT was greater than 180°, then it was 80% to the same side in TLE seizures. Versive body turning was observed in 86% of the TLE seizures, and 55% of the ETLE seizures were found to be contralateral to the EZ. When present with head turning, NVBT ipsilateral to the EZ and VBT contralateral to the EZ were more valuable for lateralization. In TLE seizures, a significant correlation was found between the head turning and body turning onsets and durations. Our study demonstrated that ictal body turning is a rarely observed but reliable lateralization finding in TLE and ETLE seizures, which also probably has the same pathophysiological mechanism as head turning in TLE seizures. © 2014 Elsevier Inc. All rights reserved.

1. Introduction The most important phase of surgical treatment decisions in focal epilepsies is the detection of the epileptogenic zone (EZ). Therefore, many semiologic and neuroimaging studies have focused on the detection of the EZ. Investigating different clinical symptoms and electroencephalography (EEG) recordings of the cortical areas activated by the EZ has revealed relationships between these behaviors and localization and lateralization of the EZ [1,2]. However, there are not enough data on the occurrence of body turning during seizures of patients with focal epilepsy, and only a few studies have investigated the role of EZ detection in ictal body turning [3–5]. Seizures containing ictal body turning are known as rotatory, volvular, circling, and gyratory seizures in the literature. Most of the data were collected from case reports, and there is no consensus about the definition [6–8]. These seizures were observed by ⁎ Corresponding author at: Gazi University Faculty of Medicine, Department of Neurology, Beşevler, 06560 Ankara, Turkey. Tel.: +90 312 202 53 28, +90 506 909 36 63 (GSM); fax: +90 312 212 90 16. E-mail address: [email protected] (M. Mercan).

http://dx.doi.org/10.1016/j.yebeh.2014.11.005 1525-5050/© 2014 Elsevier Inc. All rights reserved.

Gastaut et al. in primarily generalized epilepsy and were defined as turning of half of the body. However, some authors have stated that these seizures can also occur in focal epilepsy and defined them as at least a 180° rotation around the body axis [3,9]. The goals of this study were to 1) investigate the role of ictal body turning in focal epilepsies during the localization and lateralization of the EZ, 2) report the results of the presurgical and postsurgical evaluations, and 3) form an opinion on the pathophysiological mechanism of these seizures. 2. Methods 2.1. Patient data Two hundred and sixty-three patients with focal epilepsy were admitted to the Gazi University Faculty of Medicine (GUFOM) between 2009 and 2014 for three to seven days, on whom video-EEG monitoring was performed and who were included in the study (temporal lobe epilepsy (TLE), n = 178; extratemporal lobe epilepsy (ETLE), n = 85). After all of the videos were examined, patients with ictal body turning

254

M. Mercan et al. / Epilepsy & Behavior 44 (2015) 253–257

(n = 22) were evaluated for their clinical history, video-EEG monitoring, magnetic resonance imaging (MRI), [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET), pathology findings, and postoperative outcomes. The study was approved by the local ethics committee of the GUFOM. 2.2. Epileptic syndrome classification and seizure analysis Seizures and epileptic syndromes were classified according to the International League Against Epilepsy (ILAE) diagnostic criteria [10]. The video-EEG results and clinical symptoms were reassessed by at least two experienced epileptologists at the same time. Epileptogenic zone localization was determined based on their epilepsy surgery council decisions. Patients with focal epilepsy with ictal body turning were separated into two groups: TLE (n = 16) and ETLE (n = 6). Ictal body turning was present during complex partial seizures (CPSs) (n = 39) and/or secondarily generalized tonic–clonic seizures (sGTCSs) (n = 23). 2.2.1. Body turning terminology and inclusion–exclusion criteria Because there are insufficient data on the definition of ictal body turning in the literature, two definitions, nonversive body turning (NVBT) and versive body turning (VBT), were proposed in our study. Nonversive body turning was used to denote at least a 90° nonforced (without tonic or clonic component) rotation of the upper (shoulder) and lower (hip) parts of the body around the body axis for a minimum of 3 s. Versive body turning was used to denote at least a 90° forced (with tonic or clonic component) rotation of the upper (shoulder) and lower (hip) parts of the body around the body axis for a minimum of 3 s. Each of the patients who turned to their side to notify others of the seizure turned from the side to lie on her/his back during their aura, and those with partial consciousness who turned while watching a relative or when she/he heard a sound were excluded. The start of the rotation in the shoulder in NVBT and VBT was accepted as the onset of ictal body turning, and the end of the movement acceleration or the start of the movement to the opposite side was accepted as the ending of ictal body turning. All onsets and durations of the ictal body turning were calculated for each NVBT and VBT seizure. 2.2.2. Lateralizing motor signs Nonversive head turning (NVHT) is defined as at least a 30° involuntary head rotation lasting longer than 2 s without a forced deviation within the first 60 s of the seizure, whereas versive head turning (VHT) is defined as an involuntary and forced head rotation lasting longer than 5 s accompanied with clonic or tonic activity [11–14]. In this study, an involuntary head rotation of at least 45° from the midline (chin and sternum line) for a minimum of 3 s was regarded as NVHT. Versive head turning was assessed based on the definition in the literature. The inclusion and exclusion criteria of body turning were also applied for head turning. The onsets and durations of NVHT and VHT were calculated in the same manner as those of NVBT and VBT. Other lateralization symptoms from focal seizures that occurred besides ictal body turning, such as unilateral tonic posturing, unilateral hand automatisms, postictal nose wiping, figure-of-4 sign, and asymmetric ending of clonic jerks, were also assessed [15]. 2.3. Video-EEG and neuroimaging Continuous scalp video-EEG monitoring using 32 channels was performed with surface electrodes (with additional temporal electrodes) placed according to the international 10–20 system. Not only ictal EEG recordings during body turning but also interictal and postictal EEG changes were assessed in patients with TLE and ETLE [16]. Possible etiologic diagnoses of patients without pathology results were made using imaging. For all patients (n = 22), radiologic assessment was performed via high-resolution magnetic resonance imaging (MRI) at 3 T using a standardized epilepsy protocol. For mesial temporal

sclerosis (MTS), diagnosis of hippocampal atrophy, loss of distinction between gray matter and white matter, and a hippocampal signal increase were considered major findings [17]. The MTS diagnosis was further supported using magnetic resonance spectroscopy (MRS) findings, such as the reduction of the NAA peak and/or reduced NAA/ Cho + Cr ratio. The blood flow in the parahippocampal regions were virtually assessed using perfusion MRI and regional brain hypometabolism with 18F-FDG PET (n = 19). The dominant hemisphere for language was determined using functional MRI (n = 10). Surgical outcomes of the patients who underwent lesionectomy or anterior temporal lobectomy were assessed by Engel's classification [18]. 2.4. Statistical analyses The data were analyzed using SPSS version 15.0 for Windows. The chi-square test or Fisher's exact test, where appropriate, was used to compare the clinical or video-EEG monitoring data of patients with TLE and ETLE. The Mann–Whitney U test was performed in comparison of unequally distributed parametric variables including age, age at seizures onset, duration of epilepsy, and the body turning characteristics between both groups. Spearman's correlation was used to assess the correlation between NVBT and NVHT and VBT and VHT. p values of less than 0.05 are reported as statistically significant. 3. Results 3.1. Demographic data Sixteen patients with TLE (9%) and six patients with ETLE (7%) had at least one 90° ictal body turning in their CPSs and/or sGTCSs. Seven patients with TLE (4%) and two patients with ETLE (2%) had greater than 180° ictal body turning during at least one seizure (180°–540°). Fiftynine percent of the patients had seizures starting from the left hemisphere; this rate was 89% for patients (TLE, n = 6; ETLE, n = 2) with greater than 180° of body turning. No significant difference was observed between patients with TLE and ETLE regarding age, age at seizure onset, epilepsy duration, and risk factors (p N 0.05). The history of febrile convulsion and aura was more frequent in patients with TLE compared to patients with ETLE; however, this difference was not statistically significant (p N 0.05). Patients with TLE had autonomic (n = 7), psychic (n = 4), and vertiginous (n = 1) auras, while patients with ETLE had visual (n = 2) auras. In patients with ETLE, sGTCSs were more frequent, although this observation just missed statistical significance (p = 0.056) (Table 1). While Table 1 Clinical data of the patients. TLE (n = 16) ETLE (n = 6) p value Gender (female/male) Agea Age at seizure onset, yearsa Duration of epilepsy, yearsa Focal epilepsy with left hemisphere onset Risk factors History of febrile convulsions History of perinatal complications History of head trauma History of CNS infections Family history of epilepsy Consanguinity among parents Aura Seizure type frequency N4/month (CPSs) N1/year (sGTCSs)

10/6 26,5 (17–42) 10,5 (2–23) 15 (8–31) 11 (69%)

1/5 24 (22–42) 7,8 (4–13) 16,5 (11–35) 2 (33%)

0.740 0.630 0.297 0.711 0.178

11 (69%) 2 (13%) 3 (19%) 0 4 (25%) 3 (19%) 12 (75%)

1 (17%) 1 (17%) 3 (50%) 0 3 (50%) 2 (33%) 2 (33%)

0.560 1.000 0.283 0.334 0.585 0.137

11 (69%) 5 (31%)

5 (83%) 5 (83%)

0.634 0.560

TLE, temporal lobe epilepsy; ETLE, extratemporal lobe epilepsy; sGTCSs, secondarily generalized tonic–clonic seizures; CPSs, complex partial seizures; CNS, central nervous system. a Median (IQR).

M. Mercan et al. / Epilepsy & Behavior 44 (2015) 253–257

50% of patients with TLE had no history of sGTCSs, this rate was 17% for patients with ETLE.

3.2. Seizure semiology on video-EEG recording In the video-EEG monitoring data, the CPSs of patients with ETLE turned into sGTCSs with a statistically significantly higher rate compared to patients with TLE (p = 0.006). Nonversive body turning was only observed in CPSs. In addition, NVBT started in the first one-third part of the seizure in 91% (n = 31) of TLE seizures. This rate was 80% (n = 4) in ETLE seizures. Versive body turning was observed right before or during the tonic phase of sGTCSs. Temporal lobe onset CPSs (45% of 76 seizures) had NVBT more frequently than ETLE onset CPSs (14% of 37 seizures), which was found to be statistically significant (p = 0.002). No significant difference between TLE and ETLE seizures was found regarding the VBT frequency (p = 0.456). Additionally, no significant difference between TLE and ETLE seizures was found regarding the NVBT and VBT onsets and durations (p N 0.05) (Table 2). Nonversive body turning was observed in 6% (n = 11) of patients with TLE and 2% (n = 2) of patients with ETLE. In 76% (n = 26) of the seizures with NVBT in patients with TLE, the body rotated to the EZ's side. This rate increased to 88% when NVHT was also present with NVBT. In nearly all of the seizures, NVHT and NVBT were to the same side (except in one seizure in which NVHT and NVBT were opposite). A significant correlation between the NVHT and NVBT onsets and durations was found (rho = 0.470, p = 0.016; rho = 0.702, p = 0.000). The NVBT to the EZ's side was 80% (n = 4) in the ETLE seizures, and in only two of the five seizures, both NVHT and NVBT were present together. In 80% of the 15 TLE seizures with greater than 180° NVBT, the body rotated to the EZ's side. Versive body turning was observed in 5% (n = 8) of patients with TLE and 7% (n = 6) of patients with ETLE. In 86% (n = 12) of the seizures, VBT in patients with TLE was to the opposite side of the EZ, whereas this rate was 56% (n = 5) in the ETLE seizures. This rate increased to 92% when VHT was also present with VBT (92% in TLE seizures and 71% in ETLE seizures). Versive body turning greater than 180° occurred only in one seizure. In TLE seizures, a significant correlation was found between the VHT and VBT onsets and durations (rho = 0.826, p = 0.000; rho = 0.683, p = 0.01), whereas in ETLE seizures, the correlation between the VHT and VBT onsets and durations was

Table 2 Video-EEG monitoring data.

Total CPSs Total sGTCSs NVBT VBT NVBT onset (s)a NVBT duration (s)a VBT onset (s)a VBT duration (s)a Interictal EEG Unilateral temporal Unilateral hemispheric Ictal EEG during NVBT Unilateral T or FT Unilateral hemispheric Nonfocal and nonlateralized Postictal EEG Unilateral temporal Unilateral hemispheric

TLE (n = 16)

ETLE (n = 6)

76 27 (36%) 34 (45%) 14 (52%) 10 (0–48) 13 (3–57) 30 (14–150) 9 (4–26) n = 16 12 (75%) 4 (25%) n = 34 20 (59%) 4 (12%) 10 (29%) n = 40 14 (33%) 9 (22%)

37 24 (65%) 5 (14%) 9 (38%) 7 (1–25) 5 (3–23) 28 (17–42) 6 (4–22) n=6 0 6 (100%) n=5 0 2 (40%) 3 (60%) n = 13 0 8 (62%)

p value 0.006 0.002 0.456 0.817 0.178 0.777 0.590

TLE, temporal lobe epilepsy; ETLE, extratemporal lobe epilepsy; sGTCSs, secondarily generalized tonic–clonic seizures; CPSs, complex partial seizures; NVBT, nonversive body turning; VBT, versive body turning; T, temporal; FT, frontotemporal. Significance was assigned for all tests at p N 0.05 (bold figures). a Median (IQR).

255

not statistically significant (rho = 0.643, p = 0.119; rho = 0.057, p = 0.904). The most common lateralization findings accompanying NVBT in TLE seizures were manual automatism (n = 29; 85%), NVHT (n = 24; 71%), dystonic posture (n = 19; 56%), and postictal nose wiping (n = 4; 12%). Nonversive body turning was the only lateralization sign in 12% (n = 4) of the TLE seizures. In ETLE seizures, the lateralization findings were manual automatism (n = 1) and bilateral dystonic posture (n = 1). Versive head turning was the most common lateralization finding and was observed in the sGTCSs of patients with TLE and ETLE (93% and 78%, respectively). Asymmetric clonic ending was the second most common lateralization finding in sGTCSs with ictal body turning (TLE, 36%; ETLE, 44%), and it was always on the same side with the EZ. Lateralization signs of TLE and ETLE seizures were shown in Table 3. 3.3. EEG, imaging findings, and surgery outcomes During NVBT, rhythmical activity between 5 and 12 Hz was observed in the ictal EEG. This activity was localized in the unilateral temporal and frontotemporal regions in 59% of the TLE seizures and was lateralized to the unilateral hemisphere in 40% of the ETLE seizures (Table 2). Fifty-six percent of the patients with TLE had mesial temporal sclerosis (MTS), consistent with the MRI results (two patients' pathology results indicated MTS), and ipsilateral anterior temporal hypometabolism was the most frequent finding in 18F-FDG PET. However, in almost all other etiologic cases, except for MTS, the lesion was located in the parahippocampal region in the anterior temporal lobe. In patients with ETLE, multilobar abnormalities (e.g., frontotemporal cystic lesion and occipitoparietal DNET) were more frequently observed. It was revealed with fMRI that one patient with TLE with right NVBT had a right hemisphere dominance for language. Three patients underwent lesionectomies, and four underwent anterior temporal lobectomies (ATL); in 66% of the patients, the surgical outcome was consistent with Engel 1 (Table 4). One patient who underwent ATL was lost in follow-up. 4. Discussion In our study, ictal body turning was present in patients with both TLE and ETLE. Nonversive body turning was seen only during CPSs; however, VBT was observed right before or during the tonic phase of sGTCSs. Our study revealed that NVBT and VBT are reliable lateralization findings in TLE seizures. During most of the seizures, NVBT was ipsilateral to the EZ whereas VBT was contralateral. Moreover, NVBT was more reliable in EZ lateralization when accompanied with NVHT. A similar Table 3 Lateralization findings in complex partial seizures and secondarily generalized tonic– clonic seizures with ictal body turning. Lateralization findings

Nonversive body turning Versive body turning Nonversive head turning Versive head turning Unilateral manual automatisms Unilateral dystonic posturing Nose wiping Asymmetric ending of clonic jerks Figure-of-4 sign

Number of TLE seizures (n = 48)

Number of ETLE seizures (n = 14)

Ipsilateral

Contralateral

Ipsilateral

Contralateral

26 2 21 0 25

8 12 3 13 4

4 4 1 2 1

1 5 1 5 0

1

18

0

0

3 5

1 0

0 4

0 0

0

3

1

2

TLE, temporal lobe epilepsy; ETLE, extratemporal lobe epilepsy.

256

M. Mercan et al. / Epilepsy & Behavior 44 (2015) 253–257

Table 4 Diagnostic information. TLE (n = 16)

ETLE (n = 6)

MRI diagnosis Mesial temporal sclerosis Neuronal migration defect Tumor Vascular pathology Encephalomalacia Dual pathology Normal

9 (56%) 1 (6%) 3 (19%) 1 (6%) 0 1 (6%) 1 (6%)

0 2 (33%) 2 (33%) 0 1 (17%) 0 1 (17%)

MRS (n = 13) Lateralization Normal

9 (70%) 4 (30%)

Perfusion MRI (n = 9) Lateralization Normal

7 (77%) 2 (13%)

PET Ipsilateral AT hypometabolism Multilobar hypometabolism Normal

12 (80%) 3 (20%) 0

Functional MRI (n = 10) Left dominant hemisphere Right dominant hemisphere

9 (90%) 1 (10%)

Histopathological findings (n = 7) Hippocampal sclerosis Dysplasia Tumor Vascular pathology

3 (43%) 1 (14%) 2 (29%) 1 (14%)

Surgical outcomes (n = 6) Engel I Engel II Engel III Engel IV

4 (66%) 1 (17%) 1 (17%) 0

1 (25%) 3 (75%) 0

MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy; PET, perfusion emission tomography; and AT; anterior temporal.

situation was found for VBT in TLE seizures. According to our results, NVBT on its own is a reliable lateralization finding in ETLE seizures whereas VBT is not. This may be caused by the lower number of ETLE seizures or rapid spreading of seizure activity over both hemispheres in ETLE seizures. Data on turning during seizures are mostly based on patient statements and are defined in primarily generalized epilepsies and focal epilepsies caused by brain tumors, Wilson's disease, or tuberous sclerosis [6,7,9,19,20]. There are only a few studies conducted using video-EEG monitoring. It was stated in a study with patients with epilepsy who had 180° and greater amounts of body turning during seizures that ictal body turning was frequently present in frontal lobe epilepsies (17%) and rarely occurs in temporal lobe epilepsies (2%). It was also stated in the same study that if VHT was present before body turning, the EZ was contralateral to the body's rotation side, and if body turning did not have VHT, then it was ipsilateral to the body's rotation side [3]. A study on patients who exhibited trunk rotation of over 90° and longer than 10 s revealed that the EZ was 92% contralateral to the rotation side [4]. There is a study claiming that ictal body turning may be present in mesial frontal lobe epilepsy [5]. However, these studies used different turning definitions and are not entirely clear about the turning characteristics. Therefore, to identify ictal body turning, we recommended two definitions as NBVT and VBT according to the clinical characteristics of body movement. In the literature, NVHT was present in 70% of TLE seizures, with 87–94% being to the same side as the EZ. Nonversive head turning was usually present with dystonic extremity posture (71–96%), and it was noted that these two phenomena's pathophysiologic mechanisms may be related [11–13]. A few ictal SPECT studies indicated that during unilateral dystonia, there was hyperperfusion in the striatum and

dorsolateral thalamus ipsilateral to the EZ [21–23]. Interictal PET studies indicated that dystonic posture is related with striatal hypometabolism [24,25]. All of these studies indicate that NVHT and unilateral dystonia are associated with basal ganglia involvement. In our study, NVBT was frequently accompanied with NVHT and/or unilateral dystonia. Furthermore, a high correlation between the NVBT and NVHT characteristics was present in TLE seizures. As a result, our study suggests that TLE seizure ictal spread patterns during head and body turning may be similar. The cause of turning during seizures is not entirely understood, but there are a few hypotheses. One hypothesis suggests that the turning is due to imbalance in the striatum; imbalance in striatal dopamine due to activation in the nucleus accumbens may lead to postural asymmetry determining the rotation side. Neurochemistry studies in rats indicated that an asymmetrical increase in striatal dopamine metabolism leads to contralateral turning [26–28]. Löscher et al. state that turning is related to the decrease in ipsilateral dopamine metabolism [29]. It is also known that changes in cortical epileptiform activity or turning movements may occur with caudate nucleus stimulation [30,31]. It is claimed that in TLE seizures, when epileptic activity is spreading from the mesial structure to other zones in the hemisphere, 2- to 10-Hz frequency activity is observed in the basal ganglia, and thus, the basal ganglia prevent the spread of ictal activity to other zones in the hemisphere [32,33]. Feddersen et al. reported that unilateral dystonic posture prevents the generalization of the seizure in focal epilepsies [34]. The possible antiepileptic activity of the striatum is considered to be due to the substantia nigra pars reticulata's GABAergic modulation [35]. Jung et al. demonstrated in patients with mesial temporal lobe epilepsy that after seizure onset, a strong rhythmic 6- to 10-Hz theta to alpha activity in the ipsilateral medial temporal region was observed at the same time as a dipole cluster of the basal ganglia [36]. As a result, one may assume that altered basal ganglia activity results in turning movement during a seizure. Dystonic posture or excessive immobility in the contralateral extremity and a comparative movement increase in ipsilateral extremity (head, hand, and trunk) may lead to turning movement. In our study, we observed 5to 12-Hz rhythmic EEG activation and contralateral extremity dystonia accompanying NVHT during NVBT which support the relationship of NVBT with the activity in the basal ganglia. Versive head turning that is present in 35–45% of TLE and ETLE seizures and before sGTCSs is counted as a highly reliable lateralization finding (over 90% being contralateral to the EZ) [11,14,37]. Studies indicated that stimulation of the cortical eye field leads to contralateral head version in 58% of patients [38]; SPECT studies also support this view [23, 39]. In our study, VHT and VBT were present together in almost all of the TLE seizures and were significantly correlated. This finding supports the view that VBT occurs due to frontal eye field spreading to neighboring areas, such as VHT in TLE seizures. The reason why this correlation is not present in ELTE seizures may be the lower number of seizures, the zones being multifocal, or the differences in the ictal spread patterns. There are some limitations in our study. The lower number of ETLE seizures may affect the generalizability of the results. In addition, there is a lack of measurement tools for the calculation of the degree of body and head turnings (such as video-based software). Of the 22 patients, there were only six who underwent epilepsy surgery, and most of the patients were lost during follow-up, which makes the interpretation of the data more difficult regarding the identification of the epileptogenic zone. In conclusion, NVBT ipsilateral to the EZ and VBT contralateral to the EZ are valuable lateralization findings in TLE and ETLE seizures. When present with head turning, NVBT ipsilateral to the EZ and VBT contralateral to the EZ are more valuable for lateralization. In TLE seizures, both versive body turning and nonversive body turning are probably caused by two different pathophysiological mechanisms similarly to head turning. Whereas NVBT is more related with basal ganglia involvement, VBT seems to be related with cortical area spreading. Although a valuable lateralization finding, further studies are required to understand the pathophysiology of ictal body turning.

M. Mercan et al. / Epilepsy & Behavior 44 (2015) 253–257

Acknowledgments This study was not supported by government agencies or private foundations. Disclosure of conflicts of interest None of the authors has any conflicts of interest to disclose. We confirm that we have read the journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

References [1] Rosenow F, Luders H. Presurgical evaluation of epilepsy. Brain 2001;124:1683-00. [2] Noachtar S, Peters AS. Semiology of epileptic seizures: a critical review. Epilepsy Behav 2009;15:2–9. [3] Dobesberger J, Walser G, Embacher N, Unterberger I, Luef G, Bauer G, et al. Gyratory seizures revisited: a video-EEG study. Neurology 2005;64:1884–7. [4] Shukla G, Bhatia M, Padma Srivastava MV, Tripathi M, Srivastava A, Singh VP, et al. Unidirectional whole body turning: a new lateralising sign in complex partial seizures. J Neurol Neurosurg Psychiatry 2005;76:1726–9. [5] Leung H, Schindler K, Clusmann H, Bien CG, Pöpel A, Schramm J, et al. Mesial frontal epilepsy and ictal body turning along the horizontal body axis. Arch Neurol 2008;65: 71–7. [6] Saka E, Elibol B, Saygi S. Circling seizures in a case with Wilson's disease. Clin Electroencephalogr 1999;30:118–21. [7] Ramelli GP, Donati F, Kollar M, Remonda L, Vassella F. Rotatory seizures in a patient with tuberous sclerosis. Epileptic Disord 1999;1:233–5. [8] Donaldson IM. Volvular epilepsy. Arch Neurol 1986;43:260–2. [9] Gastaut H, Aguglia U, Tinuper P. Benign versive or circling epilepsy with bilateral 3cps spike-and-wave discharges in late childhood. Ann Neurol 1986;19:301–3. [10] Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 2010;51:676–85. [11] Wyllie E, Luders H, Morris HH, Lesser RP, Dinner DS. The lateralizing significance of versive head and eye movements during epileptic seizures. Neurology 1986;36: 606–11. [12] Abou-Khalil B, Fakhoury T. Significance of head turn sequences in temporal lobe onset seizures. Epilepsy Res 1996;233:245–50. [13] Fakhoury T, Abou-Khalil B. Association of ipsilateral head turning and dystonia in temporal lobe seizures. Epilepsia 1995;36:1065–70. [14] Bleasel A, Kotagal P, Kankirawatana P, Rybicki L. Lateralizing value and semiology of ictal limb posturing and version in temporal lobe and extratemporal epilepsy. Epilepsia 1997;38:1668–74. [15] Loddenkemper T, Kotagal P. Lateralizing signs during seizures in focal epilepsy. Epilepsy Behav 2005;7:1–17. [16] Jan MM, Sadler M, Rahey SR. Electroencephalographic features of temporal lobe epilepsy. Can J Neurol Sci 2010;37:439–48. [17] Meiners LC, van Gils A, Jansen GH, de Kort G, Witkamp TD, Ramos LM, et al. Temporal lobe epilepsy: the various MR appearances of histologically proven mesial temporal sclerosis. AJNR Am J Neuroradiol 1994;15:1547–55.

257

[18] Engel Jr J, Van Ness P, Rasmussen T. Outcome with respect to epileptic seizures. In: Engel Jr J, editor. Surgical treatment of the epilepsies. 2nd ed. New York: Raven Press; 1993. p. 609–21. [19] Leiguarda R, Nogués M, Berthier M. Gyratory epilepsy in a patient with a thalamic neoplasm. Epilepsia 1992;33:826–8. [20] Topçuoglu MA, Saygi S, Ciger A. Rotatory seizures in juvenile myoclonic epilepsy. Clin Neurol Neurosurg 1997;99:248–51. [21] Newton MR, Berkovic SF, Austin MC, Reutens DC, Mckay WJ, Bladin PF. Dystonia, clinical lateralization, and regional blood flow changes in temporal lobe seizures. Neurology 1992;42:371–7. [22] Chassagnon S, Namer IJ, Armspach JP, Nehlig A, Kahane P, Kehrli P, et al. SPM analysis of ictal interictal SPECT in mesial temporal lobe epilepsy: relationships between ictal semiology and perfusion changes. Epilepsy Res 2009;85:252–60. [23] Wong CH, Mohamed A, Larcos G, McCredie R, Somerville E, Bleasel A. Brain activation patterns of versive, hypermotor, and bilateral asymmetric tonic seizures. Epilepsia 2010;51:2131–9. [24] Dupont S, Semah F, Baulac M, Samson Y. The underlying pathophysiology of ictal dystonia in temporal lobe epilepsy: an FDG-PET study. Neurology 1998;51: 1289–92. [25] Rusu V, Chassoux F, Landré E, Bouilleret V, Nataf F, Devaux BC, et al. Dystonic posturing in seizures of mesial temporal origin: electroclinical and metabolic patterns. Neurology 2005;65:1612–9. [26] Morgan ME, Yamamoto BK, Freed CR. Unilateral activation of caudate tyrosine hydroxylase during voluntary circling behavior. J Neurochem 1984;43:737–41. [27] Yamamoto BK, Freed CR. Asymmetric dopamine and serotonin metabolism in nigrostriatal and limbic structures of the trained circling rat. Brain Res 1984;297: 115–9. [28] Fedrowitz M, Potschka H, Richter A, Löscher W. A microdialysis study of striatal dopamine release in the circling rat, a genetic animal model with spontaneous lateralized rotational behavior. Neuroscience 2000;97:69–77. [29] Löscher W, Richter A, Nikkhah G, Rosenthal C, Ebert U, Hedrich HJ. Behavioral and neurochemical dysfunction in the circling (ci) rat: a novel genetic animal model of a movement disorder. Neuroscience 1996;74:1135–42. [30] Weston J, Stein JF, Greenfield SA. Ipsiversive rotation in awake rats following chronic electrical stimulation of one caudate nucleus. Neurosci Lett 1984;46:297-03. [31] Fisher RS, Velasco AL. Electrical brain stimulation for epilepsy. Nat Rev Neurol 2014; 10:261–70. [32] Rektor I, Kuba R, Brázdil M, Halámek J, Jurák P. Ictal and peri-ictal oscillations in the human basal ganglia in temporal lobe epilepsy. Epilepsy Behav 2011;20:512–7. [33] Rektor I, Kuba R, Brázdil M. Interictal and ictal EEG activity in the basal ganglia: an SEEG study in patients with temporal lobe epilepsy. Epilepsia 2002;43: 253–62. [34] Feddersen B, Remi J, Kilian M, Vercueil L, Deransart C, depaulis A, et al. Is ictal dystonia associated with an inhibitory effect on seizure propagation in focal epilepsies? Epilepsy Res 2012;99:274–80. [35] Rektor I, Kuba R, Brázdil M, Christina J. Do the basal ganglia inhibit seizure activity in temporal lobe epilepsy? Epilepsy Behav 2012;25:56–9. [36] Jung KY, Kang JK, Kim JH, Im CH, Kim KH, Jung HK. Spatiotemporospectral characteristics of scalp ictal EEG in mesial temporal lobe epilepsy with hippocampal sclerosis. Brain Res 2009;1287:206–19. [37] Marks Jr WJ, Laxer KD. Semiology of temporal lobe seizures: value in lateralizing the seizure focus. Epilepsia 1998;39:721–6. [38] Godoy J, Lüders H, Dinner DS, Morris HH, Wyllie E. Versive eye movements elicited by cortical stimulation of the human brain. Neurology 1990;40:296–9. [39] Weder B, Oettli R, Maguire RP, Vonesch T. Partial epileptic seizure with versive movements examined by [99m Tc] HM-PAO brain single photon emission computed tomography: an early post study analyzed by computerized brain atlas methods. Epilepsia 1996;37:68–75.

Ictal body turning in focal epilepsy.

Despite the explanations of many lateralization findings, body turning in focal epilepsy has been rarely investigated. One of the aims of this study w...
237KB Sizes 1 Downloads 20 Views

Recommend Documents


Focal epilepsy with ictal abdominal pain: a case report.
Focal epilepsy with ictal abdominal pain is an unusual partial epilepsy characterized by paroxysmal episodes of abdominal or visceral pain, disturbance of awareness and electroencephalographic abnormalities. We describe a new case of ictal abdominal

A unique ictal EEG pattern in a patient with the coexistence of generalized and focal epilepsy.
The coexistence of focal and generalized epilepsy is rare. We report on a 17-year-old male with drug-resistant focal epilepsy and idiopathic generalized epilepsy (IGE). He began to experience generalized tonic-clonic seizures (GTCS) at the age of 3 y

Ictal Asystole in Focal Epilepsy: To Pace or Not to Pace?
Ictal bradyarrhythmias are rare episodes occurring in patients with or without a past cardiac history. These episodes go unnoticed unless the patient is monitored on simultaneous video-electroencephalogram and 1-lead electrocardiogram. Recognizing ic

Recurrence risk of ictal asystole in epilepsy.
To determine the recurrence risk of ictal asystole (IA) and its determining factors in people with epilepsy.

Ictal EEG modifications in temporal lobe epilepsy.
Temporal lobe epilepsy is the most common type of epilepsy in adults with medically intractable, localisation-related epilepsy, amenable to surgery. Together with clinical and neuroimaging data, presurgical ictal scalp-EEG findings are often sufficie

Eye movements differ between ictal ipsilateral and contralateral head turning.
This study evaluated the relation of head and eye movements during ictal ipsilateral and contralateral head turning in patients with focal epilepsies with regard to lateralization of the epileptogenic zone.

Ictal Coprolalia: A Case Report and Review of Ictal Speech as a Localizing Feature in Epilepsy.
Recognizing ictal semiology is an essential component to localization of seizure onset, especially in intractable epilepsy where surgical therapies may be beneficial. Ictal speech can be a common component of seizure semiology, but the various forms

Ictal high-frequency oscillations and hyperexcitability in refractory epilepsy.
High-frequency oscillations (HFOs, 80-500Hz) from intracranial electroencephalography (EEG) may represent a biomarker of epileptogenicity for epilepsy. We explored the relationship between ictal HFOs and hyperexcitability with a view to improving sur

Ictal PET in presurgical workup of refractory extratemporal epilepsy.
Ictal Pet in presurgical workup of refractory epilepsy is seldom performed and limited due to technical difficulties. In carefully selected patient subset with frequent extratemporal seizures, ictal PET depicts 'seizure onset zone' with high spatial