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BRCA2 variant aerodigestive cancer risk A rare BRCA2 genetic variant, known as rs11571833 (K3326X), is strongly associated with squamous-cell cancers of the upper aerodigestive tract (UADT), a new study reports. BRCA2 is involved in DNA repair, and previous evidence has suggested significant associations of this variant with cancers of the lung, oesophagus, and pancreas, and to a lesser degree, with breast cancer. This new study adds UADT cancers to the list of diseases affected by rs11571833. The study, led by James McKay (International Agency for Research on Cancer, Lyon, France) analysed nine UADT cancer casecontrol studies, pulling together 5942 patients with UADT and 8086 controls. Their results show that rs11571833 is significantly associated with UADT cancers

(odds ratio [OR] 2·53 [95% CI 1·89–3·38] p

Ibrutinib in pretreated Waldenström's macroglobulinaemia.

Ibrutinib in pretreated Waldenström's macroglobulinaemia. - PDF Download Free
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