European Neuropsychopharmacology, 1 (1991) 165-168 © 1991 Elsevier Science Publishers B.V. / 0924-977X/91//$3.50

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ADONIS 0924977X9100167W ENP 00025

Short c o m m u n i c a t i o n

Hypothalamic monoamines and neuropeptides in dementia A n d e r s Wallin 1, A r v i d Carlsson 2, Rolf E k m a n 3, C a r l - G e r h a r d Gottfries 1, Ingvar Karlsson 1, Lars S v e n n e r h o l m I and E r i k W i d e r l 6 v 3 lDepartment of Psychiatry and Neurochemistry, Gothenburg University, St. J6rgen's Hospital, S-422 03 Hisings Backa (Sweden), 2Department of Pharmacology, Gothenburg University, Box 33031, S-400 33 Gothenburg (Sweden), and 3Department of Psychiatry and Neurochemistry, Lund University, St. Lars Hospital, Box 638, S-220 06 Lund (Sweden) (Received 25 December, 1990) (Accepted 11 January, 1991)

Key words: Alzheimer's disease; Vascular dementia; 5-Hydroxy-indoleacetic acid; Homovanillic acid; Arginine vasopressin; Galanin; Somatostatin; Immunoreactivity

Summary

The concentrations of monoamines and various neuropeptides were determined in the hypothalamus of brains from patients with Alzheimer's disease and vascular dementia (n =26) and compared with control values (n=21). Decreased concentrations of 5-hydroxyindoleacetic acid (P

Hypothalamic monoamines and neuropeptides in dementia.

The concentrations of monoamines and various neuropeptides were determined in the hypothalamus of brains from patients with Alzheimer's disease and va...
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