Hypothalamic monoamines and neuropeptides in dementia A n d e r s Wallin 1, A r v i d Carlsson 2, Rolf E k m a n 3, C a r l - G e r h a r d Gottfries 1, Ingvar Karlsson 1, Lars S v e n n e r h o l m I and E r i k W i d e r l 6 v 3 lDepartment of Psychiatry and Neurochemistry, Gothenburg University, St. J6rgen's Hospital, S-422 03 Hisings Backa (Sweden), 2Department of Pharmacology, Gothenburg University, Box 33031, S-400 33 Gothenburg (Sweden), and 3Department of Psychiatry and Neurochemistry, Lund University, St. Lars Hospital, Box 638, S-220 06 Lund (Sweden) (Received 25 December, 1990) (Accepted 11 January, 1991)
The concentrations of monoamines and various neuropeptides were determined in the hypothalamus of brains from patients with Alzheimer's disease and vascular dementia (n =26) and compared with control values (n=21). Decreased concentrations of 5-hydroxyindoleacetic acid (P
Hypothalamic monoamines and neuropeptides in dementia.
The concentrations of monoamines and various neuropeptides were determined in the hypothalamus of brains from patients with Alzheimer's disease and va...