Author’s Accepted Manuscript Hypoglycemic, antilipidemic and antioxidant effects of valproic acid in alloxan-induced diabetic rats Abidemi J. Akindele, Edafe Otuguor, Dhirendra Singh, Duncan Ota, Adokiye S. Benebo www.elsevier.com/locate/ejphar

PII: DOI: Reference:

S0014-2999(15)30036-4 http://dx.doi.org/10.1016/j.ejphar.2015.05.044 EJP70008

To appear in: European Journal of Pharmacology Received date: 26 March 2015 Revised date: 16 May 2015 Accepted date: 20 May 2015 Cite this article as: Abidemi J. Akindele, Edafe Otuguor, Dhirendra Singh, Duncan Ota and Adokiye S. Benebo, Hypoglycemic, antilipidemic and antioxidant effects of valproic acid in alloxan-induced diabetic rats, European Journal of Pharmacology, http://dx.doi.org/10.1016/j.ejphar.2015.05.044 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Hypoglycemic, antilipidemic and antioxidant effects of valproic acid in alloxan-induced diabetic rats Abidemi J. Akindele1,*, Edafe Otuguor1, Dhirendra Singh2, Duncan Ota3, Adokiye S.

Department of Pharmacology, Therapeutics and Toxicology (PTT), Faculty of Basic Medical

Benebo4 1

Sciences, College of Medicine, University of Lagos, Idi-Araba Campus, P.M.B. 12003 Lagos,

Department of Pharmacology, Shakambhari Institute of Higher Education and Technology,

Nigeria. 2

Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University

Roorkee, Uttarakhand, India. 3

Department of Pathology and Forensic Medicine, Faculty of Basic Medical Sciences, Lagos

of Lagos, Idi-Araba Campus, P.M.B. 12003 Lagos, Nigeria. 4

Correspondence to: Department of Pharmacology, Therapeutics and Toxicology (PTT), Faculty

State University College of Medicine, P.M.B. 21266 Ikeja, Lagos, Nigeria. *

of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba Campus, P.M.B. 12003 Lagos, Nigeria; Tel: +2347011675625, +2348062359726; E-mail: [email protected], [email protected] (A.J. Akindele).

ABSTRACT This study was designed to investigate the hypoglycemic, antilipidemic and antioxidant effects of valproic acid (VA) in alloxan-induced diabetic rats. VA (100, 300 and 600 mg/kg p.o.) and insulin (17 IU/kg s.c.) were administered once daily for 21 days. Fasting blood glucose level was determined at 7 days interval. On day 21, blood samples were collected for assay of serum biochemical parameters (total protein, creatinine, urea, alanine transaminase (ALT), aspartate

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transaminase (AST), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density lipoprotein (LDL). Kidneys and livers were harvested for antioxidant indices and histopathological examination. In diabetic rats, VA produced a dose and day-dependent reduction in glucose level. Peak effect (52.79% reduction; P

Hypoglycemic, antilipidemic and antioxidant effects of valproic acid in alloxan-induced diabetic rats.

This study was designed to investigate the hypoglycemic, antilipidemic and antioxidant effects of valproic acid (VA) in alloxan-induced diabetic rats...
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