Author's Accepted Manuscript Prospective Study of Polydimethylsiloxane vs Hyaluronic Acid Injection for Treatment of Vesicoureteral Reflux Katherine Moore, Stéphane Bolduc
PII: DOI: Reference:
S0022-5347(14)03745-8 10.1016/j.juro.2014.05.116 JURO 11538
To appear in: The Journal of Urology Accepted Date: 29 May 2014 Please cite this article as: Moore K, Bolduc S, Prospective Study of Polydimethylsiloxane vs Hyaluronic Acid Injection for Treatment of Vesicoureteral Reflux, The Journal of Urology® (2014), doi: 10.1016/ j.juro.2014.05.116. DISCLAIMER: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our subscribers we are providing this early version of the article. The paper will be copy edited and typeset, and proof will be reviewed before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to The Journal pertain. All press releases and the articles they feature are under strict embargo until uncorrected proof of the article becomes available online. We will provide journalists and editors with full-text copies of the articles in question prior to the embargo date so that stories can be adequately researched and written. The standard embargo time is 12:01 AM ET on that date.
ACCEPTED MANUSCRIPT PROSPECTIVE STUDY OF POLYDIMETHYLSILOXANE VS HYALURONIC ACID INJECTION FOR TREATMENT OF VESICOURETERAL REFLUX
RI PT
Katherine Moore MD, Stéphane Bolduc MD
Division of Urology, Department of Surgery, CHU de Québec, Université Laval Québec, Canada
SC
Original scientific article
M AN U
Disclosures: None
Key words: Deflux; Endoscopic injection; Macroplastique; Urinary tract infection; Vesicoureteral reflux.
TE D
Descriptive running head: Polydimethylsiloxane vs. hyaluronic acid comparison
Word count: Abstract 250, manuscript 2456.
EP
All authors had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
AC C
No funding was provided for this work. No conflict of interest or financial disclosure exists for any of the authors.
REB : B13-08-1783
Author for correspondence: Katherine Moore, MD, FRCSC CHU de Québec, Pavillon CHUL 2705 Boul Laurier R-1742, Québec, Québec, Canada, G1V 4G2 Tel: 418-654-2282 Fax: 418-654-2137 [email protected]
2
ACCEPTED MANUSCRIPT ABSTRACT PURPOSE: Treatment of vesicoureteral reflux (VUR) with endoscopic injection of a bulking agent is becoming the first line of treatment for low grade VUR. We prospectively compared the
RI PT
efficacy of two products commercialised in Canada. MATERIAL AND METHODS:
Between April 2005 and February 2011, a total of 275 patients with documented VUR grade
SC
I-V were prospectively enrolled in a comparative study to be randomly treated endoscopically with either polydimethylsiloxane (Macroplastique®) or hyaluronic acid (Deflux®). A total of
M AN U
202 ureters were treated with Macroplastique® and 197 ureters with Deflux®. Patients were followed with voiding cystourethrography at 3 months and renal ultrasonography at 3 months and 1 year. The median follow-up is 4.3 years. The primary outcome was surgical success (resolution vs. non resolution), and secondary outcomes included the occurrence of adverse
TE D
events. RESULTS:
With Macroplastique®, VUR was fully corrected in 182 (90%) of 202 ureteral units.
EP
However, complete resolution of VUR was only recorded in 159 (81%) of 197 ureters treated with Deflux® (p
PII: DOI: Reference:
S0022-5347(14)03745-8 10.1016/j.juro.2014.05.116 JURO 11538
To appear in: The Journal of Urology Accepted Date: 29 May 2014 Please cite this article as: Moore K, Bolduc S, Prospective Study of Polydimethylsiloxane vs Hyaluronic Acid Injection for Treatment of Vesicoureteral Reflux, The Journal of Urology® (2014), doi: 10.1016/ j.juro.2014.05.116. DISCLAIMER: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our subscribers we are providing this early version of the article. The paper will be copy edited and typeset, and proof will be reviewed before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to The Journal pertain. All press releases and the articles they feature are under strict embargo until uncorrected proof of the article becomes available online. We will provide journalists and editors with full-text copies of the articles in question prior to the embargo date so that stories can be adequately researched and written. The standard embargo time is 12:01 AM ET on that date.
ACCEPTED MANUSCRIPT PROSPECTIVE STUDY OF POLYDIMETHYLSILOXANE VS HYALURONIC ACID INJECTION FOR TREATMENT OF VESICOURETERAL REFLUX
RI PT
Katherine Moore MD, Stéphane Bolduc MD
Division of Urology, Department of Surgery, CHU de Québec, Université Laval Québec, Canada
SC
Original scientific article
M AN U
Disclosures: None
Key words: Deflux; Endoscopic injection; Macroplastique; Urinary tract infection; Vesicoureteral reflux.
TE D
Descriptive running head: Polydimethylsiloxane vs. hyaluronic acid comparison
Word count: Abstract 250, manuscript 2456.
EP
All authors had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
AC C
No funding was provided for this work. No conflict of interest or financial disclosure exists for any of the authors.
REB : B13-08-1783
Author for correspondence: Katherine Moore, MD, FRCSC CHU de Québec, Pavillon CHUL 2705 Boul Laurier R-1742, Québec, Québec, Canada, G1V 4G2 Tel: 418-654-2282 Fax: 418-654-2137 [email protected]
2
ACCEPTED MANUSCRIPT ABSTRACT PURPOSE: Treatment of vesicoureteral reflux (VUR) with endoscopic injection of a bulking agent is becoming the first line of treatment for low grade VUR. We prospectively compared the
RI PT
efficacy of two products commercialised in Canada. MATERIAL AND METHODS:
Between April 2005 and February 2011, a total of 275 patients with documented VUR grade
SC
I-V were prospectively enrolled in a comparative study to be randomly treated endoscopically with either polydimethylsiloxane (Macroplastique®) or hyaluronic acid (Deflux®). A total of
M AN U
202 ureters were treated with Macroplastique® and 197 ureters with Deflux®. Patients were followed with voiding cystourethrography at 3 months and renal ultrasonography at 3 months and 1 year. The median follow-up is 4.3 years. The primary outcome was surgical success (resolution vs. non resolution), and secondary outcomes included the occurrence of adverse
TE D
events. RESULTS:
With Macroplastique®, VUR was fully corrected in 182 (90%) of 202 ureteral units.
EP
However, complete resolution of VUR was only recorded in 159 (81%) of 197 ureters treated with Deflux® (p
