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Asian Biomed (Res Rev News). Author manuscript; available in PMC 2017 February 22. Published in final edited form as: Asian Biomed (Res Rev News). 2016 June ; 10(3): 229–234.
HIV-infected children in the Asia-Pacific region with baseline severe anemia: antiretroviral therapy and outcomes
Pagakrong Lumbiganona, Pope Kosalaraksaa, Torsak Bunupuradahb, David Boettigerc, Vonthanak Saphonnd, Khanh H. Truonge, Nia Kurniatif, Rawiwan Hansudewechakulg, Viet C. Doh, Tavitiya Sudjaritruki, Nagalingeswaran Kumarasamyj, Nantakar Kongstank, Nik K. N. Yusoffl, Lam V. Nguyenm, Dewi K. Watin, Kamarul Razalio, Annette H. Sohnp, and Azar Kariminiac aDivision
of Infectious Diseases, Department of Pediatrics, Khon Kaen University, Khon Kaen 40002, Thailand bHIV-NAT, the Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand cThe Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia dNational Centre for HIV/AIDS, Dermatology and STDs (NCHADS), Phnom Penh, Cambodia eChildren's Hospital 1, Ho Chi Minh City, Vietnam fCipto Mangunkusumo General Hospital, Jakarta, Indonesia gChiangrai Prachanukroh Hospital, Chiang Rai 57000, Thailand hChildren's Hospital 2, Ho Chi Minh City, Vietnam iDepartment of Pediatrics, Faculty of Medicine, Chiang Mai University and Research Institute for Health Sciences, Chiang Mai 50200, Thailand jYRG CARE Medical Centre, CART CRS, Chennai, India kDepartment of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand lHospital Raja Perempuan Zainab II, Kelantan 15000, Malaysia mNational Hospital of Pediatrics, Hanoi, Vietnam nSanglah Hospital, Udayana University, Bali, Indonesia oPaediatric Institute Hospital Kuala Lumpur, Kuala Lumpur 50586, Malaysia pTREAT Asia/amfAR—The Foundation for AIDS Research, Bangkok 10330, Thailand
Abstract Background—Severe anemia is common among children infected with human immunodeficiency virus (HIV). The choice of antiretroviral (ART) regimen needs careful consideration. No information is available regarding the initial ART regimens used in the Asia– Pacific region and the rate of switch of ART regimens in HIV-infected children with severe anemia.
Objectives—To study the initial ART regimens and the rate of switch of ART regimens used during the first 36 months in HIV-infected children with severe anemia and to evaluate their clinical and laboratory outcomes.
Correspondence to: Pagakrong Lumbiganon, Division of Infectious Disease, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. [email protected]
Conflict of interest statement The authors declare that there is no conflict of interest in this research.
Lumbiganon et al.
Methods—We analyzed regional cohort data of 130 Asian children aged