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Ann Epidemiol. Author manuscript; available in PMC 2016 December 01. Published in final edited form as: Ann Epidemiol. 2015 December ; 25(12): 936–941.e1. doi:10.1016/j.annepidem.2015.09.001.
History of oral contraceptive use and risk of spontaneous abortion Kristen A. Hahna, Elizabeth E. Hatcha, Kenneth J. Rothmana,b, Ellen M. Mikkelsenc, Susan B. Broglya, Henrik T. Sørensena,c, Anders H. Riisc, and Lauren A. Wisea,d aDepartment
of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, 02118 USA
Author Manuscript
bRTI
Health Solutions, 3040 East Cornwallis Road, Research Triangle Park, NC, 12194 USA
cDepartment
of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43, 8200 Aarhus N, Denmark dSlone
Epidemiology Center, 1010 Commonwealth Ave, Boston, MA, 02215 USA
Abstract Purpose—To examine the association between pregravid oral contraceptive (OC) use and spontaneous abortion (SAB).
Author Manuscript
Methods—In an Internet-based preconception cohort study of 4,862 Danish pregnancy planners, we used Cox proportional hazards models to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between OC use and SAB. We controlled for maternal age, physical activity, parity, education, alcohol and caffeine consumption, body mass index, and smoking. Results—Compared with women who discontinued OCs >1 year before conception, HRs were 0.95 (95% CI: 0.77, 1.17), 0.99 (95% CI: 0.82, 1.19), and 0.80 (95% CI: 0.60, 1.06) for women who discontinued OCs 7-12, 2-6, and 0-1 months before conception, respectively. Compared with
Ann Epidemiol. Author manuscript; available in PMC 2016 December 01. Published in final edited form as: Ann Epidemiol. 2015 December ; 25(12): 936–941.e1. doi:10.1016/j.annepidem.2015.09.001.
History of oral contraceptive use and risk of spontaneous abortion Kristen A. Hahna, Elizabeth E. Hatcha, Kenneth J. Rothmana,b, Ellen M. Mikkelsenc, Susan B. Broglya, Henrik T. Sørensena,c, Anders H. Riisc, and Lauren A. Wisea,d aDepartment
of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, 02118 USA
Author Manuscript
bRTI
Health Solutions, 3040 East Cornwallis Road, Research Triangle Park, NC, 12194 USA
cDepartment
of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43, 8200 Aarhus N, Denmark dSlone
Epidemiology Center, 1010 Commonwealth Ave, Boston, MA, 02215 USA
Abstract Purpose—To examine the association between pregravid oral contraceptive (OC) use and spontaneous abortion (SAB).
Author Manuscript
Methods—In an Internet-based preconception cohort study of 4,862 Danish pregnancy planners, we used Cox proportional hazards models to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between OC use and SAB. We controlled for maternal age, physical activity, parity, education, alcohol and caffeine consumption, body mass index, and smoking. Results—Compared with women who discontinued OCs >1 year before conception, HRs were 0.95 (95% CI: 0.77, 1.17), 0.99 (95% CI: 0.82, 1.19), and 0.80 (95% CI: 0.60, 1.06) for women who discontinued OCs 7-12, 2-6, and 0-1 months before conception, respectively. Compared with
