Original Article doi: 10.1111/joim.12340
High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study C. Lewerin1, H. Johansson2, U. H. Lerner2,3, M. K. Karlsson4, M. Lorentzon2, E. Barrett-Connor5, U. Smith6, C. Ohlsson7 & D. Mellstr€om2 From the 1Section of Haematology and Coagulation, Department of Internal Medicine and Clinical Nutrition; 2Center for Bone and Arthritis Research (CBAR) and Geriatric Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg; 3Molecular Peridontology, Ume a University, Ume a ; 4Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Malm€ o, Sweden; 5Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA; 6Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg; and 7Department of Internal Medicine and Clinical Nutrition, Center for Bone and Arthritis Research (CBAR), Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
Abstract. Lewerin C, Johansson H, Lerner UH, Karlsson MK, Lorentzon M, Barrett-Connor E, Smith U, Ohlsson C, Mellstr€ om D (Institute of Medicine, University of Gothenburg, Gothenburg; Ume a University, Ume a; Lund University, Malm€ o, Sweden; University of California, San Diego, La Jolla, CA, USA; University of Gothenburg, Gothenburg; and, Sweden). High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study. J Intern Med 2015; 278: 68–76. Objectives. Blood haemoglobin (Hb) concentration declines in elderly men, whilst the level of the adipocyte-derived protein adiponectin increases with age. The association between erythropoiesis and adiponectin in elderly men is unclear. The aim of this study was to determine whether adipokines such as adiponectin and leptin are associated with anaemia and Hb concentration in elderly community-dwelling men. Design and setting. The Gothenburg part of the population-based Swedish Osteoporotic Fractures in Men (MrOS) cohort (n = 1010; median age 75.3 years, range 69–81). Main outcome measures. We investigated the associations between levels of adiponectin and Hb before and after adjusting for potential confounders [i.e. age, body composition, erythropoietin (EPO), total
Introduction Blood haemoglobin (Hb) concentration declines with age in apparently healthy elderly individuals [1, 2], and this association is more pronounced in men than women [2]. The reason for this decline is
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oestradiol, leptin, cystatin C and iron and B vitamin status]. Results. In these elderly men, age was negatively associated with Hb (r = 0.12, P < 0.001) and positively associated with adiponectin level (r = 0.13, P < 0.001). In age-adjusted partial correlations, Hb and adiponectin levels were negatively correlated (r = 0.20, P < 0.001); this association remained significant after multivariable adjustment for age, body composition, EPO, fasting insulin, sex hormones, leptin and ferritin. Age-adjusted mean adiponectin concentrations were significantly higher in anaemic men (66/1005; Hb
High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study C. Lewerin1, H. Johansson2, U. H. Lerner2,3, M. K. Karlsson4, M. Lorentzon2, E. Barrett-Connor5, U. Smith6, C. Ohlsson7 & D. Mellstr€om2 From the 1Section of Haematology and Coagulation, Department of Internal Medicine and Clinical Nutrition; 2Center for Bone and Arthritis Research (CBAR) and Geriatric Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg; 3Molecular Peridontology, Ume a University, Ume a ; 4Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Malm€ o, Sweden; 5Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA; 6Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg; and 7Department of Internal Medicine and Clinical Nutrition, Center for Bone and Arthritis Research (CBAR), Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
Abstract. Lewerin C, Johansson H, Lerner UH, Karlsson MK, Lorentzon M, Barrett-Connor E, Smith U, Ohlsson C, Mellstr€ om D (Institute of Medicine, University of Gothenburg, Gothenburg; Ume a University, Ume a; Lund University, Malm€ o, Sweden; University of California, San Diego, La Jolla, CA, USA; University of Gothenburg, Gothenburg; and, Sweden). High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study. J Intern Med 2015; 278: 68–76. Objectives. Blood haemoglobin (Hb) concentration declines in elderly men, whilst the level of the adipocyte-derived protein adiponectin increases with age. The association between erythropoiesis and adiponectin in elderly men is unclear. The aim of this study was to determine whether adipokines such as adiponectin and leptin are associated with anaemia and Hb concentration in elderly community-dwelling men. Design and setting. The Gothenburg part of the population-based Swedish Osteoporotic Fractures in Men (MrOS) cohort (n = 1010; median age 75.3 years, range 69–81). Main outcome measures. We investigated the associations between levels of adiponectin and Hb before and after adjusting for potential confounders [i.e. age, body composition, erythropoietin (EPO), total
Introduction Blood haemoglobin (Hb) concentration declines with age in apparently healthy elderly individuals [1, 2], and this association is more pronounced in men than women [2]. The reason for this decline is
68
ª 2014 The Association for the Publication of the Journal of Internal Medicine
oestradiol, leptin, cystatin C and iron and B vitamin status]. Results. In these elderly men, age was negatively associated with Hb (r = 0.12, P < 0.001) and positively associated with adiponectin level (r = 0.13, P < 0.001). In age-adjusted partial correlations, Hb and adiponectin levels were negatively correlated (r = 0.20, P < 0.001); this association remained significant after multivariable adjustment for age, body composition, EPO, fasting insulin, sex hormones, leptin and ferritin. Age-adjusted mean adiponectin concentrations were significantly higher in anaemic men (66/1005; Hb
