High-fiber diet reduces serum in premenopausal women3 David

P Rose,

Madeleine

ABSTRACU

Goldman,

The effect

concentrations

was

estimated

daily

of -

1 5 g to 30 g/d

bran.

This

of dietary

studied

dietary

Jeanne

fiber

intake

fat consumption.

without

After

bran-supplemented

2 mo on the group

from

showed

centrations. The serum estrogens fiber supplementation with oat Nuir 1991:54:520-5.

wheat-

reductions

unaffected brans.

interpretation

con-

by dietary-

Am J Clin

WORDS

Dietary

serum

estrogens,

wheat

of the

results

fiber

and

between

estradiol

effects

estimated

(24),

by the

fat consumption

inverse

for the combined

oriental

of dietary

daily

concentrations

is complicated

of premenopausal women.

the

discernible of a second

change study

proximately

fiber,

plasma

between

To separate

described

and

immigrants

fat and

fiber

and

on circulating

estrogens, we previously performed a study in which total fat consumed was reduced to -20% of calories without

corn

KEY

was also

intake

relationship

in

globulin

correlation fiber

data in this study American Caucasian

0.02) but no change




only

ported previous allergy supplement prescribed

age-ad-

estimated

premenopausal

been

For patients confirmed

25 g were

past

12 mo,

thyroid and

the oat-

for the

from

participants occasional

to one ofthe was determined

use or cor-

a personal

can-

4-d food calories

further

by computer were

or corn-bran

and/ were

current

hormone

excluded

analyzed

by

abnormalities, from the study

two sets of preintervention a fat intake of< 25% oftotal

a wheat-,

made

the with

than

to either

had

treatment

all

cycles.

mammographic Exclusion criteria

cer history. Those whose records (FDFRs) indicated fiber

were

menstrual

the diagnosis

or breast-feeding

ticosteroids

study

regular

disease

contraceptives,

exception

by

paruse

of

randomly

supplement; individual

flours. The amount by the average

an who

re-

of fiber value de-

(16, an as-

(20).

I From the Division ofNutrition and Endocrinology, Foundation, New York. 2 Supported in part by a grant from the Kellogg

Creek. MI. 3 Address docrinology,

influence plasma (2 1 ) and post-

of total

and

in this y with

cyst aspirations, examinations.

assigned

cancer risk, one of homogeneity

significant reductions from a typical amount

of 35-40%

been

Some

20-50

ticipation. The FDFRs were the DIAN database (25). After the initial evaluation

breast

supported

successful or biopsy

or a dietary

mamcom-

the the

(12-15).

studies

that dietary fat may in both premenopausal

menopausal (22, when consumption American

and

are

has

benign

of oral

after

10). human

between

design,

participants

aged

pregnancy

nullicancer is

to regress

62

women with

estroa role

acts to promote ( 1 1 ). International cancer

all ( 18, 19), case-control

practices

dem-

Emphasis

correlation breast

17), but

dietary

studies

of tumors and

to controversy.

amounts

of the

one-third dependence

fat, which undoubtedly in animal models

a strong

mortality

con-

of circulating (2-7), whereas

or antiestrogen therapy (9, of diet as a factor influencing

remains

The

abnor-

attention

late menopause, (8). Once breast

approximately

retained

precise

case-control

experimental

in the

is also supported by epidemiologic a positive relationship between

cancer risk and early menarche, and a delayed first pregnancy

clinically

the major

in the concentrations biological availability

for the sex-steroid hormones investigations that demonstrate

are involved

although

to be established,

on the estrogens.

onstrated differences gens ( 1 , 2) and their

hormones

occurring for Caucalories.

Apn J C/in Nuir

Health

Company,

Battle

of Nutrition and EnRoad, Valhalla, NY

10595.

A 1991:54:520-5.

Downloaded from https://academic.oup.com/ajcn/article-abstract/54/3/520/4694296 by Emil Unanue on 11 June 2018

reprint requests to DP Rose, Division American Health Foundation, Dana

American

Received Accepted Printed

October 10, 1990. for publication February in USA.

© 1991 American

14, 1991. Society

for Clinical

Nutrition

DIETARY TABLE

FIBER

AND

ESTROGENS

521

radioimmunoassays

I

Fiber-portion

exchange

list

chased

Bran

Dietary

fiber

cooking

IMuffin

28.4 g Kellogg’s Bran Rakes 14.2 g Kellogg’s All Bran 12.5 g Raw unprocessed wheat Corn bran IMuffin

bran

I 10 g fresh, frozen. or vacuum-packed

28.4 g Popcorn.

corn

with

phase evaporated by using specific limit

L. The intraassay

5

± 4. 1% and

5

for the estradiol assay were progesterone concentrations

5

tube

5

chemicals

5

subject

were

SHBG

analyzed

kits

ofboth

of variation were

kits

obtained

and

due

were

determined

from from

Wien

ICN

from

the FDFRs,

fiber

intake

the goal

to a minimum

The

as muffins: 0.48

g); for wheat,

and

raisins,

advised

to eat

diet and sources.

plement;

bran

or

The periods

for

each

Each

Serum

by radioimmunoassay

Laboratories.

The

assay

fact, were

cycle

(Battle

estradiol,

days

18 and

progesterone

such

2 1 ofthe

blood

obtained

consent

estrogen,

estradiol

and

normal

unpaired

in accordance

Review Foundation.

Board

progesterone,

and

volume stored assays estrone

of blood

for

gesterone

sup-

either sample

data

who

had

analysis

assay

SHBG

was collected;

entered

was

an anovulatory in the midluteal

were

proges-

concentrations

a normal were

the

study

at least 16.0