Am J Cancer Res 2015;5(8):2409-2421 www.ajcr.us /ISSN:2156-6976/ajcr0011226
Original Article High expression of S100P is associated with unfavorable prognosis and tumor progression in patients with epithelial ovarian cancer Xiangyu Wang1, Tian Tian1, Xukun Li2, Meng Zhao3, Yanhui Lou1, Jingfeng Qian1, Zhihua Liu2, Hongyan Chen2, Zhumei Cui1 Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao 266003, People’s Republic of China; 2State Key Lab of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, People’s Republic of China; 3Department of Orthopaedics, The Central Hospital of Zibo Mining Group, Zibo 255120, People’s Republic of China 1
Received June 9, 2015; Accepted July 7, 2015; Epub July 15, 2015; Published August 1, 2015 Abstract: Accumulating evidence has demonstrated that S100P is involved in the tumorigenesis and progression of multiple cancers. In the current study, we evaluated the expression of S100P in epithelial ovarian cancer and assessed its relevance to clinicopathological characteristics. Moreover, we investigated the biological effects of S100P using A2780 and SKOV3 cells. S100P expression was significantly increased in epithelial ovarian cancer specimens compared with fallopian tube tissues and normal ovary tissues. And high expression of S100P in epithelial ovarian cancer samples was significantly associated with tumor stage (P
Original Article High expression of S100P is associated with unfavorable prognosis and tumor progression in patients with epithelial ovarian cancer Xiangyu Wang1, Tian Tian1, Xukun Li2, Meng Zhao3, Yanhui Lou1, Jingfeng Qian1, Zhihua Liu2, Hongyan Chen2, Zhumei Cui1 Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao 266003, People’s Republic of China; 2State Key Lab of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, People’s Republic of China; 3Department of Orthopaedics, The Central Hospital of Zibo Mining Group, Zibo 255120, People’s Republic of China 1
Received June 9, 2015; Accepted July 7, 2015; Epub July 15, 2015; Published August 1, 2015 Abstract: Accumulating evidence has demonstrated that S100P is involved in the tumorigenesis and progression of multiple cancers. In the current study, we evaluated the expression of S100P in epithelial ovarian cancer and assessed its relevance to clinicopathological characteristics. Moreover, we investigated the biological effects of S100P using A2780 and SKOV3 cells. S100P expression was significantly increased in epithelial ovarian cancer specimens compared with fallopian tube tissues and normal ovary tissues. And high expression of S100P in epithelial ovarian cancer samples was significantly associated with tumor stage (P
