Scandinavian Journal of Infectious Diseases
ISSN: 0036-5548 (Print) 1651-1980 (Online) Journal homepage: http://www.tandfonline.com/loi/infd19
Hepatitis C Virus Infection and Hepatosplenic Schistosomiasis S. Bassily, K. C. Hyams, N. A. Ei-masry, N. F. Hassan & D. M. Watts To cite this article: S. Bassily, K. C. Hyams, N. A. Ei-masry, N. F. Hassan & D. M. Watts (1992) Hepatitis C Virus Infection and Hepatosplenic Schistosomiasis, Scandinavian Journal of Infectious Diseases, 24:5, 687-688, DOI: 10.3109/00365549209054660 To link to this article: http://dx.doi.org/10.3109/00365549209054660
Published online: 08 Jul 2009.
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Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=infd19 Download by: [RMIT University Library]
Date: 31 March 2016, At: 02:04
Scand J Infect Dis 24: 687-688. 1992
LETTER TO THE EDITORS
Downloaded by [RMIT University Library] at 02:04 31 March 2016
Hepatitis C Virus Infection and Hepatosplenic Schistosomiasis Hepatosplenic schistosomiasis is a chronic disease of the liver and spleen caused by Schistosoma mansoni. Although hepatosplenic schistosomiasis results from eggs deposited in the liver with subsequent granuloma formation and periportal fibrosis, other factors are thought to be involved since most S. mansoni infected individuals do not develop this severe form of disease (1,2). Hepatitis C (parcnterally transmitted non-A, non-B hepatitis) can cause chronic hepatitis and cirrhosis and may be related to the development of hepatocellular carcinoma (3,4). Consequently, hepatitis C virus (HCV) infection could be a cofactor in the development of hepatosplenic disease by increasing the liver and splccn pathology produced by S. mansoni infection. To investigate the possible role of HCV infection in the development of hepatosplenic schistosomiasis. 23 farmers. 3 manual laborers, and 5 students with a history of schistosomiasis living in the Nile delta region of Egypt were evaluated for HCV infection. Sera were tested by ELISA (Abbott) for total anti-HCV using a second generation assay and for markers of hepatitis B infection (HBsAg and total anti-HBc). Samples repeatedly reactive for anti-HCV by ELISA were further verified with a second generation immunoblot assay (RIBA, Chiron). The mean age of the 31 study subjects was 28.0 years (range 10-58); all were male. 13 (41.9%) subjects were positive for anti-HCV by immunoblot assay. The 13 anti-HCV positive subjects were older than the 18 negative subjects: mean of 39 years compared to 20 years respectively (JJ
ISSN: 0036-5548 (Print) 1651-1980 (Online) Journal homepage: http://www.tandfonline.com/loi/infd19
Hepatitis C Virus Infection and Hepatosplenic Schistosomiasis S. Bassily, K. C. Hyams, N. A. Ei-masry, N. F. Hassan & D. M. Watts To cite this article: S. Bassily, K. C. Hyams, N. A. Ei-masry, N. F. Hassan & D. M. Watts (1992) Hepatitis C Virus Infection and Hepatosplenic Schistosomiasis, Scandinavian Journal of Infectious Diseases, 24:5, 687-688, DOI: 10.3109/00365549209054660 To link to this article: http://dx.doi.org/10.3109/00365549209054660
Published online: 08 Jul 2009.
Submit your article to this journal
Article views: 5
View related articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=infd19 Download by: [RMIT University Library]
Date: 31 March 2016, At: 02:04
Scand J Infect Dis 24: 687-688. 1992
LETTER TO THE EDITORS
Downloaded by [RMIT University Library] at 02:04 31 March 2016
Hepatitis C Virus Infection and Hepatosplenic Schistosomiasis Hepatosplenic schistosomiasis is a chronic disease of the liver and spleen caused by Schistosoma mansoni. Although hepatosplenic schistosomiasis results from eggs deposited in the liver with subsequent granuloma formation and periportal fibrosis, other factors are thought to be involved since most S. mansoni infected individuals do not develop this severe form of disease (1,2). Hepatitis C (parcnterally transmitted non-A, non-B hepatitis) can cause chronic hepatitis and cirrhosis and may be related to the development of hepatocellular carcinoma (3,4). Consequently, hepatitis C virus (HCV) infection could be a cofactor in the development of hepatosplenic disease by increasing the liver and splccn pathology produced by S. mansoni infection. To investigate the possible role of HCV infection in the development of hepatosplenic schistosomiasis. 23 farmers. 3 manual laborers, and 5 students with a history of schistosomiasis living in the Nile delta region of Egypt were evaluated for HCV infection. Sera were tested by ELISA (Abbott) for total anti-HCV using a second generation assay and for markers of hepatitis B infection (HBsAg and total anti-HBc). Samples repeatedly reactive for anti-HCV by ELISA were further verified with a second generation immunoblot assay (RIBA, Chiron). The mean age of the 31 study subjects was 28.0 years (range 10-58); all were male. 13 (41.9%) subjects were positive for anti-HCV by immunoblot assay. The 13 anti-HCV positive subjects were older than the 18 negative subjects: mean of 39 years compared to 20 years respectively (JJ
