European Heart Journal (1990) 11 (Supplement H), 1-3
HDL metabolism and its role in lipid transport N. E. MILLER
Bowman Gray School of Medicine, Winston-Salem, North Carolina, U.S.A. KEY WORDS: High density lipoproteins, apolipoproteins, very low density lipoproteins, lipid transport.
Composition and structure of HDL11"31 The high density lipoprotein (HDL) particle consists of a surface coat and an inner component, or core, as do all lipoproteins. The surface coat is composed of the apolipoproteins (50-55% of total HDL mass), unesterified cholesterol (4°/0), and phospholipid (20-30%). The core contains primarily cholesteryl esters (14-18%) and a small amount of triglyceride (3-6%). Proteins constitute about half of HDL mass by weight, resulting in a relatively low lipid-to-protein ratio as well as a high density compared with other lipoproteins. Several apolipoproteins (apos) have been identified, the most important being apo A-I and A-II; C-I, C-II and C-III; and E. Apo A-I, the major protein of HDL, is the most prominent in terms of total mass, and has
several properties critical to the function of HDL. P ° A - ! j s an important structural component; it has amphipathic helices that enable the apoprotein t o l i e a t th th e h ld c o ° '"terface ^ f " * of ? ° f P ar le and ac ueous hase o f lasma A P f ^ j Pr P : PU° f"1
HDL metabolism and its role in lipid transport N. E. MILLER
Bowman Gray School of Medicine, Winston-Salem, North Carolina, U.S.A. KEY WORDS: High density lipoproteins, apolipoproteins, very low density lipoproteins, lipid transport.
Composition and structure of HDL11"31 The high density lipoprotein (HDL) particle consists of a surface coat and an inner component, or core, as do all lipoproteins. The surface coat is composed of the apolipoproteins (50-55% of total HDL mass), unesterified cholesterol (4°/0), and phospholipid (20-30%). The core contains primarily cholesteryl esters (14-18%) and a small amount of triglyceride (3-6%). Proteins constitute about half of HDL mass by weight, resulting in a relatively low lipid-to-protein ratio as well as a high density compared with other lipoproteins. Several apolipoproteins (apos) have been identified, the most important being apo A-I and A-II; C-I, C-II and C-III; and E. Apo A-I, the major protein of HDL, is the most prominent in terms of total mass, and has
several properties critical to the function of HDL. P ° A - ! j s an important structural component; it has amphipathic helices that enable the apoprotein t o l i e a t th th e h ld c o ° '"terface ^ f " * of ? ° f P ar le and ac ueous hase o f lasma A P f ^ j Pr P : PU° f"1
