Journal of Infection (2014) 68, 176e184
www.elsevierhealth.com/journals/jinf
Vitamin D deficiency is associated with severity of liver disease in HIV/HCV coinfected patients a,e n-Fulgencio a,e, Mo nica Garcı´a-Alvarez Marı´a Guzma , b,c a ´nez-Sousa , Jaime Cosı´n b, Juan Berenguer , Ma Angeles Jime miz b,c, Daniel Pineda-Tenor a, Ana Carrero b,c, Teresa Alda d b pez , Salvador Resino a,* , Juan Carlos Lo Emilio Alvarez
a
Unit of Viral Infection and Immunity, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain b Infectious Diseases e HIV Unit, Hospital General Universitario “Gregorio Maran~on”, Madrid, Spain c Health Research Institute “Gregorio Maran~on”, Madrid, Spain d Pathology Department, Hospital General Universitario “Gregorio Maran~on”, Madrid, Spain Accepted 25 October 2013 Available online 1 November 2013
KEYWORDS Vitamin D; AIDS; Chronic hepatitis C; Liver fibrosis; Hepatic biopsy; Antiviral therapy
Summary Objective: To study the association of plasma 25-hydroxy vitamin D (25(OH)D) levels in HIV/HCV coinfected patients with severity of liver disease and virological response to hepatitis C virus (HCV) therapy with pegylated-interferon-alpha plus ribavirin (pegIFNa/ RBV). Methods: A cross-sectional study in 174 HIV/HCV coinfected patients that underwent a liver biopsy previously to start HCV therapy and a retrospective study of 125 of them. Plasma 25(OH)D levels were quantified by enzyme immunoassay. Liver biopsies were evaluated by METAVIR score. A sustained virological response (SVR) was defined as an undetectable serum HCV viral load (
www.elsevierhealth.com/journals/jinf
Vitamin D deficiency is associated with severity of liver disease in HIV/HCV coinfected patients a,e n-Fulgencio a,e, Mo nica Garcı´a-Alvarez Marı´a Guzma , b,c a ´nez-Sousa , Jaime Cosı´n b, Juan Berenguer , Ma Angeles Jime miz b,c, Daniel Pineda-Tenor a, Ana Carrero b,c, Teresa Alda d b pez , Salvador Resino a,* , Juan Carlos Lo Emilio Alvarez
a
Unit of Viral Infection and Immunity, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain b Infectious Diseases e HIV Unit, Hospital General Universitario “Gregorio Maran~on”, Madrid, Spain c Health Research Institute “Gregorio Maran~on”, Madrid, Spain d Pathology Department, Hospital General Universitario “Gregorio Maran~on”, Madrid, Spain Accepted 25 October 2013 Available online 1 November 2013
KEYWORDS Vitamin D; AIDS; Chronic hepatitis C; Liver fibrosis; Hepatic biopsy; Antiviral therapy
Summary Objective: To study the association of plasma 25-hydroxy vitamin D (25(OH)D) levels in HIV/HCV coinfected patients with severity of liver disease and virological response to hepatitis C virus (HCV) therapy with pegylated-interferon-alpha plus ribavirin (pegIFNa/ RBV). Methods: A cross-sectional study in 174 HIV/HCV coinfected patients that underwent a liver biopsy previously to start HCV therapy and a retrospective study of 125 of them. Plasma 25(OH)D levels were quantified by enzyme immunoassay. Liver biopsies were evaluated by METAVIR score. A sustained virological response (SVR) was defined as an undetectable serum HCV viral load (
