is

likely

to be overcome

tion in the method

by a slight modificaemployed. Accordingly

now

efforts will be directed to the elaboration of a process which shall confer on the inoculated, in addition to the more permanent action of the

vaccines,

a

temporary

the first ten of

and

rapid immunity during

days. those made at

Gya are indicating the direction and improvements in the

Observations such

as

great importance

in

in which modifications methods now in use have to be

Jndian jptitdiflal da^tti;.

more

the

obtained, provements

SEPTEMBER 1894.

which must

HAFFKINE'S PREVENTIVE INOCULATIONS AT GYA JAIL. We draw the attention of our readers to Br. Macrae's very full and valuable report on the results of anti-choleraic inoculations in

Gya Jail prevailing. It

a time when an epidemic was will be noted that the observations here made refer mainly to the period of ten days, which

at

claimed as necessary to produce the protective effect of the inoculations, the first requiring about five days, and the second a similar period.

are

It has been

a

question

influence aimed at that

The

period.

show that

ning,

an

was

Gya experience

seems

to

effect, though small in the besjin-

produced,

is

whether the protective of any effect within

and that

this

the

gradually

increases. Thus dividing Gya epidemic into three periods, the following results were obtained with about the

same

number

inoculated

as

not

inoculated:? 1st 5

Not inoculated Inoculated ...

2nd period 3 days.

period days.

3rd 6

period days.

Cases. Deaths. Cases. Deaths. Cases. Deaths. 5 5 3 7 2 8 4 3 1 5 0 0

It will be observed that during the first eight days there were 12 cases and eight deaths among

inoculated, and eight cases and five deaths the inoculated, and that after this when among the second inoculations had had time to act that no further cases or deaths occurred among the

the not

inoculated,

while there

were

eight

cases

deaths among the non-inoculated.

and two

The incon-

venience in the face of an outbreak of eight days to elapse before the full protective power of the vaccines is obtained, as also occurs in vac-

having

cination

against small-pox,

is

one

which

happily

effected,

of these kind of observations that more

which

rapid

and the can

are likely experience will suggest,

necessarily

be

to be the imand

follow the introduction

of a new system. In the meantime the observations made by Dr. Macrae under unique conditions? and here recorded?will constitute a very valuable addition to our knowledge on this im-

portant subject.

Haffkine's Preventive Inoculation.

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