Haemostatic Profile of Patients with Chronic Liver Disease- its Correlation with Severity and Outcome

Pathology Section

DOI: 10.7860/JCDR/2017/24975.10451

Original Article

Varnika Rai1, Neeraj Dhameja2, Sandip Kumar3, Jyoti Shukla4, Rajeev Singh5, Vinod Kumar Dixit6

ABSTRACT Introduction: The liver plays an important role in the haemostatic system as it synthesizes the majority of coagulation factors and fibrinolytic proteins. Aim: The present study was planned to determine the range of haemostatic defects in patients of chronic liver diseases. Materials and Methods: Test performed included Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT), Thrombin Time (TT), Fibrinogen, Protein C, D Dimer and platelet count. Comparisons between groups frequencies and groups means were made using Chi-square test and Student’s t-test, respectively. Results: In cirrhosis group PT, aPTT, TT and D Dimer level were

significantly increased compared to Chronic Hepatitis (CH) and control group (p

Haemostatic Profile of Patients with Chronic Liver Disease- its Correlation with Severity and Outcome.

The liver plays an important role in the haemostatic system as it synthesizes the majority of coagulation factors and fibrinolytic proteins...
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