Acta Clinica Belgica International Journal of Clinical and Laboratory Medicine
ISSN: 1784-3286 (Print) 2295-3337 (Online) Journal homepage: http://www.tandfonline.com/loi/yacb20
Haemophagocytic lymphohistiocytosis and dengue V. Wiwanitkit To cite this article: V. Wiwanitkit (2015) Haemophagocytic lymphohistiocytosis and dengue, Acta Clinica Belgica, 70:1, 72-72, DOI: 10.1179/2295333714Y.0000000040 To link to this article: http://dx.doi.org/10.1179/2295333714Y.0000000040
Published online: 04 Feb 2015.
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Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=yacb20 Download by: [Gazi University]
Date: 31 March 2016, At: 03:58
Letter to the Editor
Haemophagocytic lymphohistiocytosis and dengue V. Wiwanitkit1,2,3 1
Hainan Medical University, China, 2Faculty of Medicine, University of Nis, Serbia, 3Joseph Ayobabalola University, Nigeria
Downloaded by [Gazi University] at 03:58 31 March 2016
Sir, the recent report on ‘haemophagocytic lymphohistiocytosis and dengue’ is very interesting.1 de Koninck et al. reported a case of dengue with haemophagocytic lymphohistiocytosis and noted that ‘as dengue is a rising pathogen in tropical import diseases, clinicians must be aware of its rare but serious complications’.1 In fact, dengue can have several uncommon manifestations and complications and this can make the diagnosismore difficult.2 ‘Haemophagocytic lymphohistiocytosis, is sporadically seen in clinical practice.3 Sharp et al. noted that ‘persistent fever, pancytopenia, hepatosplenomegaly, and increased serum ferritin’ is the main finding.3 The diagnosis of this condition, is usually difficult and requires bone marrow examination.2,3 The problem is common in a dengue case with multiple organ disorder.4 The important consideration is the possible concomitant condition disorder that can result in
haemophagocytic lymphohistiocytosis. Good examples are sepsis5 and some viral infections (such as West Nile virus infection3).
References 1 de Koninck AS, Dierick J, Steyaert S, Taelman P. Hemophagocytic lymphohistiocytosis and dengue infection: rare case report. Acta Clin Belg. 2014;69(3):210–3 2 Wiwanitkit V. Dengue fever: diagnosis and treatment. Expert Rev Anti Infect Ther. 2010;8(7):841–5. 3 Sharp TM, Gaul L, Muehlenbachs A, Hunsperger E, Bhatnagar J, Lueptow R, et al.; Centers for Disease Control and Prevention (CDC). Fatal hemophagocytic lymphohistiocytosis associated with locally acquired dengue virus infection — New Mexico and Texas, 2012. MMWR Morb Mortal Wkly Rep. 2014;63(3):49–54. 4 Raju S, Kalyanaraman S, Swaminathan K, Nisha A, Praisid S. Hemophagocytic lymphohistiocytosis syndrome in dengue hemorrhagic fever. Indian J Pediatr. 2014;81(12):1381–3. 5 Raschke RA, Garcia-Orr R. Hemophagocytic lymphohistiocytosis: a potentially underrecognized association with systemic inflammatory response syndrome, severe sepsis, and septic shock in adults. Chest. 2011;140(4):933–8.
Correspondence to: V. W., Wiwanitkit House, Bangkhae, Bangkok 10160, Thailand. Email: [email protected]
72
ß Acta Clinica Belgica 2015 DOI 10.1179/2295333714Y.0000000040
Acta Clinica Belgica
2015
VOL.
70
NO.
1
ISSN: 1784-3286 (Print) 2295-3337 (Online) Journal homepage: http://www.tandfonline.com/loi/yacb20
Haemophagocytic lymphohistiocytosis and dengue V. Wiwanitkit To cite this article: V. Wiwanitkit (2015) Haemophagocytic lymphohistiocytosis and dengue, Acta Clinica Belgica, 70:1, 72-72, DOI: 10.1179/2295333714Y.0000000040 To link to this article: http://dx.doi.org/10.1179/2295333714Y.0000000040
Published online: 04 Feb 2015.
Submit your article to this journal
Article views: 10
View related articles
View Crossmark data
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=yacb20 Download by: [Gazi University]
Date: 31 March 2016, At: 03:58
Letter to the Editor
Haemophagocytic lymphohistiocytosis and dengue V. Wiwanitkit1,2,3 1
Hainan Medical University, China, 2Faculty of Medicine, University of Nis, Serbia, 3Joseph Ayobabalola University, Nigeria
Downloaded by [Gazi University] at 03:58 31 March 2016
Sir, the recent report on ‘haemophagocytic lymphohistiocytosis and dengue’ is very interesting.1 de Koninck et al. reported a case of dengue with haemophagocytic lymphohistiocytosis and noted that ‘as dengue is a rising pathogen in tropical import diseases, clinicians must be aware of its rare but serious complications’.1 In fact, dengue can have several uncommon manifestations and complications and this can make the diagnosismore difficult.2 ‘Haemophagocytic lymphohistiocytosis, is sporadically seen in clinical practice.3 Sharp et al. noted that ‘persistent fever, pancytopenia, hepatosplenomegaly, and increased serum ferritin’ is the main finding.3 The diagnosis of this condition, is usually difficult and requires bone marrow examination.2,3 The problem is common in a dengue case with multiple organ disorder.4 The important consideration is the possible concomitant condition disorder that can result in
haemophagocytic lymphohistiocytosis. Good examples are sepsis5 and some viral infections (such as West Nile virus infection3).
References 1 de Koninck AS, Dierick J, Steyaert S, Taelman P. Hemophagocytic lymphohistiocytosis and dengue infection: rare case report. Acta Clin Belg. 2014;69(3):210–3 2 Wiwanitkit V. Dengue fever: diagnosis and treatment. Expert Rev Anti Infect Ther. 2010;8(7):841–5. 3 Sharp TM, Gaul L, Muehlenbachs A, Hunsperger E, Bhatnagar J, Lueptow R, et al.; Centers for Disease Control and Prevention (CDC). Fatal hemophagocytic lymphohistiocytosis associated with locally acquired dengue virus infection — New Mexico and Texas, 2012. MMWR Morb Mortal Wkly Rep. 2014;63(3):49–54. 4 Raju S, Kalyanaraman S, Swaminathan K, Nisha A, Praisid S. Hemophagocytic lymphohistiocytosis syndrome in dengue hemorrhagic fever. Indian J Pediatr. 2014;81(12):1381–3. 5 Raschke RA, Garcia-Orr R. Hemophagocytic lymphohistiocytosis: a potentially underrecognized association with systemic inflammatory response syndrome, severe sepsis, and septic shock in adults. Chest. 2011;140(4):933–8.
Correspondence to: V. W., Wiwanitkit House, Bangkhae, Bangkok 10160, Thailand. Email: [email protected]
72
ß Acta Clinica Belgica 2015 DOI 10.1179/2295333714Y.0000000040
Acta Clinica Belgica
2015
VOL.
70
NO.
1
