Neuroradiology DOI 10.1007/s00234-015-1499-3
LETTER TO THE EDITOR
Guillain Barré syndrome-related posterior reversible encephalopathy syndrome Giulio Zuccoli & Raffaele Nardone & Abdel-Hamid Hoda
Received: 20 January 2015 / Accepted: 27 January 2015 # Springer-Verlag Berlin Heidelberg 2015
Dear Sir, Reversible posterior encephalopathy syndrome (PRES), first described by Hinchey et al. in 1996, is a neurological condition characterized by headache, nausea/ vomiting, seizures, visual field disturbances, altered sensorium, decreased alertness, and focal neurological deficits. The main finding of PRES on magnetic resonance imaging (MRI) is usually bilateral, often symmetric, posterior white matter hyperintensity on T2 weighted images, consistent with vasogenic edema [1]. PRES can develop in association with a variety of conditions that may cause acute alteration of blood pressure such as preeclampsia/eclampsia, as well exposure to chemotherapeutic drugs. Concurrent occurrence of GuillainBarré syndrome (GBS) with PRES is a rare entity and only a few cases have been reported. GBS is considered a post-infectious syndrome triggered by different organisms or illnesses. The pathophysiology of the disease is most likely due to molecular mimicry. We report the unique case of PRES in a child with EpsteinBarr virus (EBV) infection-related GBS.
G. Zuccoli (*) Section of Neuroradiology, Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, 4401 Penn Avenue, Floor 2, Pittsburgh, PA 15224, USA e-mail: [email protected] R. Nardone Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria A.
LETTER TO THE EDITOR
Guillain Barré syndrome-related posterior reversible encephalopathy syndrome Giulio Zuccoli & Raffaele Nardone & Abdel-Hamid Hoda
Received: 20 January 2015 / Accepted: 27 January 2015 # Springer-Verlag Berlin Heidelberg 2015
Dear Sir, Reversible posterior encephalopathy syndrome (PRES), first described by Hinchey et al. in 1996, is a neurological condition characterized by headache, nausea/ vomiting, seizures, visual field disturbances, altered sensorium, decreased alertness, and focal neurological deficits. The main finding of PRES on magnetic resonance imaging (MRI) is usually bilateral, often symmetric, posterior white matter hyperintensity on T2 weighted images, consistent with vasogenic edema [1]. PRES can develop in association with a variety of conditions that may cause acute alteration of blood pressure such as preeclampsia/eclampsia, as well exposure to chemotherapeutic drugs. Concurrent occurrence of GuillainBarré syndrome (GBS) with PRES is a rare entity and only a few cases have been reported. GBS is considered a post-infectious syndrome triggered by different organisms or illnesses. The pathophysiology of the disease is most likely due to molecular mimicry. We report the unique case of PRES in a child with EpsteinBarr virus (EBV) infection-related GBS.
G. Zuccoli (*) Section of Neuroradiology, Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, 4401 Penn Avenue, Floor 2, Pittsburgh, PA 15224, USA e-mail: [email protected] R. Nardone Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria A.
