573 GROWTH-HORMONE RESPONSE TO HÆMODIALYSIS IN CHILDREN
ing haemodialysis.4 response in children on hxmodialysis is not well understood, and we need to know how much the growth of these children is affected. KUNLE IJAIYA MONIKA BULLA B. ROTH Department of Pædiatrics, E. GLADTKE University of Cologne, 5000 Cologne 41, West Germany A. SCHWENK
The
SIR,-Hawkins and Strang’ measured growth hormone (G.H.) and glucose concentrations at the start and at completion of dialysis in adult patients on regular hEemodialysis for chronic failure. In most patients the G.H. value fell considerably during dialysis against a fluid containing glucose. We have studied four ursemic children (three girls and a boy) aged 10-15 years. All were normally on maintenance dialysis for 5 h three times per week with capillary dialysers against a fluid containing 5.55 mmol/1 (100 mg/dl) glucose. The G.H. concentrations in these children were investigated during dialysis with and without glucose (in three patients) in dialysate. Before the second investigation, of dialysis without
DOES KARTAGENER’S SYNDROME EXIST?
dialysate, the three children had 1 week of dialysis without glucose in the dialysate. All children have short stature (below 2 S.D. or 3rd percentile). In patients B, C, and D, G.H. response to insulin-induced hypoglycxmia and arginine infusion, studied previously, had been normal. Samples were collected from blood lines before and after the dialyser. G.H. in heparinised plasma with and without glucose in dialysate was estimated by double-antibody radioimmunoassay; plasma-glucose was measured by glucose-6phosphate-dehydrogenase method. The results are shown in the table. In all patients undergoing dialysis against a fluid containing glucose the plasma-G.H. fell considerably (r
ing haemodialysis.4 response in children on hxmodialysis is not well understood, and we need to know how much the growth of these children is affected. KUNLE IJAIYA MONIKA BULLA B. ROTH Department of Pædiatrics, E. GLADTKE University of Cologne, 5000 Cologne 41, West Germany A. SCHWENK
The
SIR,-Hawkins and Strang’ measured growth hormone (G.H.) and glucose concentrations at the start and at completion of dialysis in adult patients on regular hEemodialysis for chronic failure. In most patients the G.H. value fell considerably during dialysis against a fluid containing glucose. We have studied four ursemic children (three girls and a boy) aged 10-15 years. All were normally on maintenance dialysis for 5 h three times per week with capillary dialysers against a fluid containing 5.55 mmol/1 (100 mg/dl) glucose. The G.H. concentrations in these children were investigated during dialysis with and without glucose (in three patients) in dialysate. Before the second investigation, of dialysis without
DOES KARTAGENER’S SYNDROME EXIST?
dialysate, the three children had 1 week of dialysis without glucose in the dialysate. All children have short stature (below 2 S.D. or 3rd percentile). In patients B, C, and D, G.H. response to insulin-induced hypoglycxmia and arginine infusion, studied previously, had been normal. Samples were collected from blood lines before and after the dialyser. G.H. in heparinised plasma with and without glucose in dialysate was estimated by double-antibody radioimmunoassay; plasma-glucose was measured by glucose-6phosphate-dehydrogenase method. The results are shown in the table. In all patients undergoing dialysis against a fluid containing glucose the plasma-G.H. fell considerably (r
