Nephro! Dial Transplant (1992) 7: 246-250 £, 1992 European Dialysis and Transplant Association-European Renal Association
Nephrology Dialysis Transplantation
Original Article Growth hormone response to acute growth hormone releasing hormone administration in uraemic patients on haemodialysis S. Donnay, F. Garcia-Martin, E. Martin-Escobar, G. De Arriba, J. L. Agud and R. Requejo Endocrinology Unit, Nephrology Unit and Internal Medicine Department, Hospital Virgen de la Luz, Cuenca, Spain
Abstract. To examine the response of growth hormone (GH) to growth hormone releasing factor (GHRF) in patients on haemodialysis, we performed the acute G H R F test (50 \x% administered intravenously as a bolus) in 10 uraemic male patients on haemodialysis and eight normal controls. Each patient was tested before and after a haemodialysis session (at 08.30 and 12.30). Controls were tested on the same time schedule. At 08.30, patients had significantly greater basal and peak GH values (2.5 ±0.6 and 27.8 ± 5.5 ug/1) than controls (0.68 ±0.1 and 11.5 ± 4 ug/1). After the haemodialysis session, basal and peak values declined significantly (/ ) the urea kinetic model, showed a mean Kt V value of 1.12 ±0.1 (range 0.9-1.4). There were no undernourished patients and all had protein catabolic rates < 0.9 g kg day. All patients received aluminium hjdroxide, calcium supplementation and multivitamins (complex B plus C); none was treated with beta-blocking or other antihypertensive drugs. The control group consisted of eight healthy males (mean age 39.1 ±2.7 years, range 28-55 years). All subjects were informed of the nature of the study and consent was obtained. The study conformed to accepted ethical standards and legal regulation.
Patients showed significantly greater pre-haemodialysis growth hormone values (2.82*0.6 £g 1) than did healthy controls at 08.30 (0.67±0.1 ug 1) (P