Endocrine Care 581

Growth Hormone Receptor Gene Expression in Puberty

Authors

S. Pagani1, C. Meazza1, C. Gertosio2, E. Bozzola3, M. Bozzola1

Affiliations

1

Key words ▶ IGF-I ● ▶ pubertal spurt ● ▶ prepubertal girls ●

Abstract

Bibliography DOI http://dx.doi.org/ 10.1055/s-0034-1395591 Published online: January 20, 2015 Horm Metab Res 2015; 47: 581–584 © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043 Correspondence M. Bozzola, MD Internal Medicine and ­Therapeutics Department Unit of Pediatrics and ­Adolescentology University of Pavia Fondazione IRCCS San Matteo Piazzale Golgi 2 27100 Pavia Italy Tel.:  + 39/038/2501 270 Fax:  + 39/038/2502 876 [email protected]



The mechanisms regulating the synergic effect of growth hormone and other hormones during pubertal spurt are not completely clarified. We enrolled 64 females of Caucasian origin and normal height including 22 prepubertal girls, 26 pubertal girls, and 16 adults to evaluate the role of Growth Hormone/Insulin-like growth factor-I axis (GH/IGF-I) during the pubertal period. In these subjects both serum IGF-I and growth hormone binding protein levels, as well as quantitative growth hormone receptor (GHR) gene expression were evaluated in peripheral lymphocytes of all individuals by real-time PCR. Our results showed significantly lower IGF-I levels in women (148 ± 10 ng/ml) and prepubertal girls (166.34 ± 18.85 ng/ml) compared to pubertal girls (441.95 ± 29.42 ng/ml; p 

Growth hormone receptor gene expression in puberty.

The mechanisms regulating the synergic effect of growth hormone and other hormones during pubertal spurt are not completely clarified. We enrolled 64 ...
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