A E R
Editor‑in‑Chief : Mohamad Said Maani Takrouri (KSA)
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For entire Editorial Board visit : http://www.aeronline.org/editorialboard.asp
Anesthesia: Essays and Researches
Original Article
Granisetron versus ondansetron for post‑operative nausea and vomiting prophylaxis in elective craniotomies for brain tumors: A randomized controlled double‑blind study Priyanka Gupta, Nikki Sabharwal1, Suniti Kale1, Mayank Gupta2, Anoop R. Gogia1 Chacha Nehru Bal Chikitsalya, 1Department of Anaesthesia and Intensive Care, Vardhaman Mahavir Medical College and Safdarjung Hospital, 2Max Super Speciality Hospital, Saket, New Delhi, India Corresponding author: Dr. Mayank Gupta, 14, Himvihar Apartments, I.P. Extension, New Delhi ‑ 110 092, India. E‑mail: [email protected]
Abstract Context: Post‑operative nausea and vomiting (PONV) pose unique challenges in neurosurgical patients that warrant its study separate from other surgical groups. Setting and Design: This prospective, randomized, double‑blind study was carried out to compare and to evaluate the efficacy and safety of three antiemetic combinations for PONV prophylaxis following craniotomy. Materials and Methods: A total of 75 anesthesiologist status I/II patients undergoing elective craniotomy for brain tumors were randomized into three groups, G, O and D, to receive single doses of dexamethasone 8 mg at induction with either granisetron 1 mg, ondansetron 4 mg or normal saline 2 ml at the time of dural closure respectively. Episodes of nausea, retching, vomiting and number of rescue antiemetic (RAE) were noted for 48 h post‑operatively. Statistical Analysis: Analysis of variance with post‑hoc significance and Chi‑square test with fisher exact correction were used for statistical analysis. P
Editor‑in‑Chief : Mohamad Said Maani Takrouri (KSA)
Open Access HTML Format
For entire Editorial Board visit : http://www.aeronline.org/editorialboard.asp
Anesthesia: Essays and Researches
Original Article
Granisetron versus ondansetron for post‑operative nausea and vomiting prophylaxis in elective craniotomies for brain tumors: A randomized controlled double‑blind study Priyanka Gupta, Nikki Sabharwal1, Suniti Kale1, Mayank Gupta2, Anoop R. Gogia1 Chacha Nehru Bal Chikitsalya, 1Department of Anaesthesia and Intensive Care, Vardhaman Mahavir Medical College and Safdarjung Hospital, 2Max Super Speciality Hospital, Saket, New Delhi, India Corresponding author: Dr. Mayank Gupta, 14, Himvihar Apartments, I.P. Extension, New Delhi ‑ 110 092, India. E‑mail: [email protected]
Abstract Context: Post‑operative nausea and vomiting (PONV) pose unique challenges in neurosurgical patients that warrant its study separate from other surgical groups. Setting and Design: This prospective, randomized, double‑blind study was carried out to compare and to evaluate the efficacy and safety of three antiemetic combinations for PONV prophylaxis following craniotomy. Materials and Methods: A total of 75 anesthesiologist status I/II patients undergoing elective craniotomy for brain tumors were randomized into three groups, G, O and D, to receive single doses of dexamethasone 8 mg at induction with either granisetron 1 mg, ondansetron 4 mg or normal saline 2 ml at the time of dural closure respectively. Episodes of nausea, retching, vomiting and number of rescue antiemetic (RAE) were noted for 48 h post‑operatively. Statistical Analysis: Analysis of variance with post‑hoc significance and Chi‑square test with fisher exact correction were used for statistical analysis. P
