RESEARCH ARTICLE
Gout and Risk of Myocardial Infarction: A Systematic Review and Meta-Analysis of Cohort Studies Shuang-Chun Liu1☯, Lei Xia2☯, Jin Zhang1, Xue-Hong Lu3, Da-Kang Hu1, HaiTao Zhang4‡*, Hai-Jun Li5‡* 1 Department of Clinical Laboratory, Taizhou Municipal Hospital, Taizhou, Zhejiang, China, 2 Department of Urinary Surgery, Affiliated Renji Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, China, 3 Department of Pediatrics, Taizhou Municipal Hospital, Taizhou, Zhejiang, China, 4 Department of Urinary Surgery, Taizhou Municipal Hospital,Taizhou, Zhejiang, China, 5 Department of Neurology, Taizhou Municipal Hospital, Taizhou, Zhejiang, China ☯ These authors contributed equally to this work. ‡ These authors also contributed equally to this work. * [email protected] (HTZ); [email protected] (HJL)
Abstract OPEN ACCESS Citation: Liu S-C, Xia L, Zhang J, Lu X-H, Hu D-K, Zhang H-T, et al. (2015) Gout and Risk of Myocardial Infarction: A Systematic Review and Meta-Analysis of Cohort Studies. PLoS ONE 10(7): e0134088. doi:10.1371/journal.pone.0134088
Introduction A high incidence of myocardial infarction among patients with gout has been suggested by several observational studies. We performed a meta-analysis to evaluate the association between gout and the risk of myocardial infarction.
Editor: Carmine Pizzi, University of Bologna, ITALY Received: January 16, 2015 Accepted: July 6, 2015 Published: July 31, 2015 Copyright: © 2015 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The present study was supported by Medical Science and Technology Support of Zhejiang Province (2013ZHB015). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist.
Materials and Methods The PubMed and Embase databases were searched from inception to October 2014 for cohort studies that evaluating the association between gout and the risk of myocardial infarction. Summary estimates were derived using a random-effects model and reported as relative risks (RRs) with 95% confidence intervals (CIs).
Results Five studies involving 8,656,413 participants with a total of 1000 MI events were included. Overall, gout was associated with an increased risk of myocardial infarction (RR 1.45; 95% CI, 1.19–1.75; p
Gout and Risk of Myocardial Infarction: A Systematic Review and Meta-Analysis of Cohort Studies Shuang-Chun Liu1☯, Lei Xia2☯, Jin Zhang1, Xue-Hong Lu3, Da-Kang Hu1, HaiTao Zhang4‡*, Hai-Jun Li5‡* 1 Department of Clinical Laboratory, Taizhou Municipal Hospital, Taizhou, Zhejiang, China, 2 Department of Urinary Surgery, Affiliated Renji Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, China, 3 Department of Pediatrics, Taizhou Municipal Hospital, Taizhou, Zhejiang, China, 4 Department of Urinary Surgery, Taizhou Municipal Hospital,Taizhou, Zhejiang, China, 5 Department of Neurology, Taizhou Municipal Hospital, Taizhou, Zhejiang, China ☯ These authors contributed equally to this work. ‡ These authors also contributed equally to this work. * [email protected] (HTZ); [email protected] (HJL)
Abstract OPEN ACCESS Citation: Liu S-C, Xia L, Zhang J, Lu X-H, Hu D-K, Zhang H-T, et al. (2015) Gout and Risk of Myocardial Infarction: A Systematic Review and Meta-Analysis of Cohort Studies. PLoS ONE 10(7): e0134088. doi:10.1371/journal.pone.0134088
Introduction A high incidence of myocardial infarction among patients with gout has been suggested by several observational studies. We performed a meta-analysis to evaluate the association between gout and the risk of myocardial infarction.
Editor: Carmine Pizzi, University of Bologna, ITALY Received: January 16, 2015 Accepted: July 6, 2015 Published: July 31, 2015 Copyright: © 2015 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The present study was supported by Medical Science and Technology Support of Zhejiang Province (2013ZHB015). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist.
Materials and Methods The PubMed and Embase databases were searched from inception to October 2014 for cohort studies that evaluating the association between gout and the risk of myocardial infarction. Summary estimates were derived using a random-effects model and reported as relative risks (RRs) with 95% confidence intervals (CIs).
Results Five studies involving 8,656,413 participants with a total of 1000 MI events were included. Overall, gout was associated with an increased risk of myocardial infarction (RR 1.45; 95% CI, 1.19–1.75; p
