HHS Public Access Author manuscript Author Manuscript
Fertil Steril. Author manuscript; available in PMC 2016 November 01. Published in final edited form as: Fertil Steril. 2015 November ; 104(5): 1145–52.e1-5. doi:10.1016/j.fertnstert.2015.07.1151.
Gonadotropin dose is negatively correlated with live birth rate: analysis of over 650,000 ART cycles Valerie L. Baker, M.D.1,*, Morton B. Brown, Ph.D2, Barbara Luke, Sc.D, M.P.H.3, George W. Smith, Ph.D4, and James J. Ireland, Ph.D5 1Division
of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94304
Author Manuscript
2Department
of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI
48109 3Department
of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, MI 48823
4Laboratory
of Mammalian Reproductive Biology and Genomics, Department of Animal Science, Michigan State University, East Lansing, MI 48824 5Molecular
Reproductive Endocrinology Laboratory, Department of Animal Science, Michigan State University, East Lansing, MI 48824
Abstract Author Manuscript
Objective—To evaluate the correlation between total gonadotropin dose and live birth rate Design—Retrospective analysis Setting—Clinic-based data Patients—658,519 fresh autologous cycles of in vitro fertilization (IVF) reported to the Society for Assisted Reproductive Technology from 2004 to 2012 Interventions—None
Author Manuscript
Main outcome measures—Logistic regression models were fitted to live birth rates using categorized values for total follicle stimulating hormone (FSH) dose and number of oocytes retrieved as the primary predictor variables. To reduce the effect of the most significant confounders which may lead physicians to prescribe higher doses of FSH, additional analyses were performed limited to good prognosis patients (
Fertil Steril. Author manuscript; available in PMC 2016 November 01. Published in final edited form as: Fertil Steril. 2015 November ; 104(5): 1145–52.e1-5. doi:10.1016/j.fertnstert.2015.07.1151.
Gonadotropin dose is negatively correlated with live birth rate: analysis of over 650,000 ART cycles Valerie L. Baker, M.D.1,*, Morton B. Brown, Ph.D2, Barbara Luke, Sc.D, M.P.H.3, George W. Smith, Ph.D4, and James J. Ireland, Ph.D5 1Division
of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94304
Author Manuscript
2Department
of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI
48109 3Department
of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, MI 48823
4Laboratory
of Mammalian Reproductive Biology and Genomics, Department of Animal Science, Michigan State University, East Lansing, MI 48824 5Molecular
Reproductive Endocrinology Laboratory, Department of Animal Science, Michigan State University, East Lansing, MI 48824
Abstract Author Manuscript
Objective—To evaluate the correlation between total gonadotropin dose and live birth rate Design—Retrospective analysis Setting—Clinic-based data Patients—658,519 fresh autologous cycles of in vitro fertilization (IVF) reported to the Society for Assisted Reproductive Technology from 2004 to 2012 Interventions—None
Author Manuscript
Main outcome measures—Logistic regression models were fitted to live birth rates using categorized values for total follicle stimulating hormone (FSH) dose and number of oocytes retrieved as the primary predictor variables. To reduce the effect of the most significant confounders which may lead physicians to prescribe higher doses of FSH, additional analyses were performed limited to good prognosis patients (
