Author's Accepted Manuscript
Glutamate and GABA contributions to medial prefrontal cortical activity to emotion: Implications for mood disorders D Stan, Ana, V Schirda, Claudiu, A Bertocci, Michele, M Bebko, Genna, M Kronhaus, Dina, A Aslam, Haris, J LaBarbara, Eduard, Costin Tanase, C Lockovich, Jeanette, H Pollock, Myrna, S Stiffler, Richelle, L Phillips, Mary www.elsevier.com/locate/psychresns
PII: DOI: Reference:
S0925-4927(14)00149-8 http://dx.doi.org/10.1016/j.pscychresns.2014.05.016 PSYN10219
To appear in:
Psychiatry Research: Neuroimaging
Received date: 17 December 2013 Revised date: 27 May 2014 Accepted date: 28 May 2014 Cite this article as: D Stan, Ana, V Schirda, Claudiu, A Bertocci, Michele, M Bebko, Genna, M Kronhaus, Dina, A Aslam, Haris, J LaBarbara, Eduard, Costin Tanase, C Lockovich, Jeanette, H Pollock, Myrna, S Stiffler, Richelle, L Phillips, Mary, Glutamate and GABA contributions to medial prefrontal cortical activity to emotion: Implications for mood disorders, Psychiatry Research: Neuroimaging, http://dx.doi.org/10.1016/j.pscychresns.2014.05.016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Glutamate and GABA contributions to medial prefrontal cortical activity to emotion: implications for mood disorders
Authors:
Stan, Ana, D*a, b Schirda, Claudiu, Vc Bertocci, Michele, Ad Bebko, Genna, Md Kronhaus, Dina, Me Aslam, Haris, Ad LaBarbara, Eduard, Jd Tanase, Costinf Lockovich, Jeanette, Cd Pollock, Myrna, Hd Stiffler, Richelle, Sd Phillips, Mary, Ld
Author Affiliations: a. University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA
b. Currently at UT Southwestern Medical Center at Dallas, TX c. University of Pittsburgh, Department of Radiology, Magnetic Resonance Research Center d. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh e. Centre for Music and Science, Faculty of Music, University of Cambridge, UK f. University of California Davis, Department of Psychiatry and Behavioral Sciences
Corresponding author:
Ana D. Stan Department of Psychiatry University of Texas Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX, 75390-9127 Phone: 214-645-8941 Fax: 214-645-2786 E-mail: ana.̷Ǥ
Abstract
Background. The dorsomedial prefrontal cortex (MdPFC) and anterior cingulate cortices (ACC) play a critical role in implicit emotion regulation, however the understanding of the specific neurotransmitters that mediate such role is lacking. In this study, we examined relationships
between MdPFC concentrations of two neurotransmitters, glutamate and
-amino butyric acid
(GABA), and BOLD activity in ACC during performance of an implicit facial emotionprocessing task. Methods. 20 healthy volunteers, aged 20-35 years, were scanned while performing an implicit facial emotion-processing task, whereby presented facial expressions changed from neutral to one of the four emotions: happy, anger, fear, or sad. Glutamate concentrations were measured before and after the emotion-processing task in right MdPFC using magnetic resonance spectroscopy (MRS). GABA concentrations were measured in bilateral MdPFC after the emotion-processing task. Multiple regression models were run to determine the relative contribution of glutamate and GABA concentration, age, and gender to BOLD signal in ACC to each of the four emotions. Results. Multiple regression analyses revealed a significant negative correlation between MdPFC GABA concentration and BOLD signal in subgenual ACC (p
Glutamate and GABA contributions to medial prefrontal cortical activity to emotion: Implications for mood disorders D Stan, Ana, V Schirda, Claudiu, A Bertocci, Michele, M Bebko, Genna, M Kronhaus, Dina, A Aslam, Haris, J LaBarbara, Eduard, Costin Tanase, C Lockovich, Jeanette, H Pollock, Myrna, S Stiffler, Richelle, L Phillips, Mary www.elsevier.com/locate/psychresns
PII: DOI: Reference:
S0925-4927(14)00149-8 http://dx.doi.org/10.1016/j.pscychresns.2014.05.016 PSYN10219
To appear in:
Psychiatry Research: Neuroimaging
Received date: 17 December 2013 Revised date: 27 May 2014 Accepted date: 28 May 2014 Cite this article as: D Stan, Ana, V Schirda, Claudiu, A Bertocci, Michele, M Bebko, Genna, M Kronhaus, Dina, A Aslam, Haris, J LaBarbara, Eduard, Costin Tanase, C Lockovich, Jeanette, H Pollock, Myrna, S Stiffler, Richelle, L Phillips, Mary, Glutamate and GABA contributions to medial prefrontal cortical activity to emotion: Implications for mood disorders, Psychiatry Research: Neuroimaging, http://dx.doi.org/10.1016/j.pscychresns.2014.05.016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Glutamate and GABA contributions to medial prefrontal cortical activity to emotion: implications for mood disorders
Authors:
Stan, Ana, D*a, b Schirda, Claudiu, Vc Bertocci, Michele, Ad Bebko, Genna, Md Kronhaus, Dina, Me Aslam, Haris, Ad LaBarbara, Eduard, Jd Tanase, Costinf Lockovich, Jeanette, Cd Pollock, Myrna, Hd Stiffler, Richelle, Sd Phillips, Mary, Ld
Author Affiliations: a. University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA
b. Currently at UT Southwestern Medical Center at Dallas, TX c. University of Pittsburgh, Department of Radiology, Magnetic Resonance Research Center d. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh e. Centre for Music and Science, Faculty of Music, University of Cambridge, UK f. University of California Davis, Department of Psychiatry and Behavioral Sciences
Corresponding author:
Ana D. Stan Department of Psychiatry University of Texas Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX, 75390-9127 Phone: 214-645-8941 Fax: 214-645-2786 E-mail: ana.̷Ǥ
Abstract
Background. The dorsomedial prefrontal cortex (MdPFC) and anterior cingulate cortices (ACC) play a critical role in implicit emotion regulation, however the understanding of the specific neurotransmitters that mediate such role is lacking. In this study, we examined relationships
between MdPFC concentrations of two neurotransmitters, glutamate and
-amino butyric acid
(GABA), and BOLD activity in ACC during performance of an implicit facial emotionprocessing task. Methods. 20 healthy volunteers, aged 20-35 years, were scanned while performing an implicit facial emotion-processing task, whereby presented facial expressions changed from neutral to one of the four emotions: happy, anger, fear, or sad. Glutamate concentrations were measured before and after the emotion-processing task in right MdPFC using magnetic resonance spectroscopy (MRS). GABA concentrations were measured in bilateral MdPFC after the emotion-processing task. Multiple regression models were run to determine the relative contribution of glutamate and GABA concentration, age, and gender to BOLD signal in ACC to each of the four emotions. Results. Multiple regression analyses revealed a significant negative correlation between MdPFC GABA concentration and BOLD signal in subgenual ACC (p
