G e s t a t i o n a l Tro p h o b l a s t i c Disease Alampady K.P. Shanbhogue, MDa,*, Neeraj Lalwani, MDb, Christine O. Menias, MDc KEYWORDS Hydatidiform mole Choriocarcinoma Magnetic resonance imaging
KEY POINTS With the advent of routine ultrasonographic examination in first trimester, most molar pregnancies now present with findings of early pregnancy failure rather than the classic “cluster of grapes” appearance. Ultrasonography has low sensitivity, but high positive predictive value, for the diagnosis of molar pregnancy. Pelvic magnetic resonance (MR) imaging can accurately depict the degree of uterine myometrial and extrauterine invasion in malignant gestational trophoblastic disease, and thus aids in the anatomic staging of disease. Imaging detection of persistent trophoblastic disease on pelvic MR imaging is determined by the extent of tumor burden as quantified by b–human chorionic gonadotropin (b-hCG) levels. Patients with low b-hCG levels (
KEY POINTS With the advent of routine ultrasonographic examination in first trimester, most molar pregnancies now present with findings of early pregnancy failure rather than the classic “cluster of grapes” appearance. Ultrasonography has low sensitivity, but high positive predictive value, for the diagnosis of molar pregnancy. Pelvic magnetic resonance (MR) imaging can accurately depict the degree of uterine myometrial and extrauterine invasion in malignant gestational trophoblastic disease, and thus aids in the anatomic staging of disease. Imaging detection of persistent trophoblastic disease on pelvic MR imaging is determined by the extent of tumor burden as quantified by b–human chorionic gonadotropin (b-hCG) levels. Patients with low b-hCG levels (
![[Gestational trophoblastic disease].](/assets/img/hold.png)
