RESEARCH ARTICLE
Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy Stuart K. Kim1*, Thomas R. Roos1,2, Andrew K. Roos1,2, John P. Kleimeyer3, Marwa A. Ahmed3, Gabrielle T. Goodlin4, Michael Fredericson3, John P. A. Ioannidis5,6,7, Andrew L. Avins8, Jason L. Dragoo3*
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1 Department Developmental Biology, Stanford University Medical Center, Stanford CA, United States of America, 2 Department Health Research and Policy, Division of Epidemiology, Stanford University Medical Center, Stanford CA, United States of America, 3 Department Orthopaedic Surgery, Stanford University Medical Center, Stanford CA, United States of America, 4 College of Medicine, California Northstate University, Elk Grove CA, United States of America, 5 Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford CA, United States of America, 6 Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford CA, United States of America, 7 Department of Statistics, Stanford University School of Humanities and Sciences, Stanford CA, United States of America, 8 Kaiser Permanente Northern California, Division of Research, Oakland, California, United States of America * [email protected] (SKK); [email protected] (JLD)
OPEN ACCESS Citation: Kim SK, Roos TR, Roos AK, Kleimeyer JP, Ahmed MA, Goodlin GT, et al. (2017) Genomewide association screens for Achilles tendon and ACL tears and tendinopathy. PLoS ONE 12(3): e0170422. https://doi.org/10.1371/journal. pone.0170422 Editor: James H-C Wang, University of Pittsburgh, UNITED STATES Received: September 2, 2016 Accepted: January 4, 2017 Published: March 30, 2017 Copyright: © 2017 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the manuscript, supporting information files, and hosted at the following URL: http://cmgm. stanford.edu/~kimlab/ACL/Achilles_ACL.html. Data will also be available at NIH GRASP: https://grasp. nhlbi.nih.gov/FullResults.aspx.
Abstract Achilles tendinopathy or rupture and anterior cruciate ligament (ACL) rupture are substantial injuries affecting athletes, associated with delayed recovery or inability to return to competition. To identify genetic markers that might be used to predict risk for these injuries, we performed genome-wide association screens for these injuries using data from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort consisting of 102,979 individuals. We did not find any single nucleotide polymorphisms (SNPs) associated with either of these injuries with a p-value that was genome-wide significant (p
Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy Stuart K. Kim1*, Thomas R. Roos1,2, Andrew K. Roos1,2, John P. Kleimeyer3, Marwa A. Ahmed3, Gabrielle T. Goodlin4, Michael Fredericson3, John P. A. Ioannidis5,6,7, Andrew L. Avins8, Jason L. Dragoo3*
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1 Department Developmental Biology, Stanford University Medical Center, Stanford CA, United States of America, 2 Department Health Research and Policy, Division of Epidemiology, Stanford University Medical Center, Stanford CA, United States of America, 3 Department Orthopaedic Surgery, Stanford University Medical Center, Stanford CA, United States of America, 4 College of Medicine, California Northstate University, Elk Grove CA, United States of America, 5 Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford CA, United States of America, 6 Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford CA, United States of America, 7 Department of Statistics, Stanford University School of Humanities and Sciences, Stanford CA, United States of America, 8 Kaiser Permanente Northern California, Division of Research, Oakland, California, United States of America * [email protected] (SKK); [email protected] (JLD)
OPEN ACCESS Citation: Kim SK, Roos TR, Roos AK, Kleimeyer JP, Ahmed MA, Goodlin GT, et al. (2017) Genomewide association screens for Achilles tendon and ACL tears and tendinopathy. PLoS ONE 12(3): e0170422. https://doi.org/10.1371/journal. pone.0170422 Editor: James H-C Wang, University of Pittsburgh, UNITED STATES Received: September 2, 2016 Accepted: January 4, 2017 Published: March 30, 2017 Copyright: © 2017 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the manuscript, supporting information files, and hosted at the following URL: http://cmgm. stanford.edu/~kimlab/ACL/Achilles_ACL.html. Data will also be available at NIH GRASP: https://grasp. nhlbi.nih.gov/FullResults.aspx.
Abstract Achilles tendinopathy or rupture and anterior cruciate ligament (ACL) rupture are substantial injuries affecting athletes, associated with delayed recovery or inability to return to competition. To identify genetic markers that might be used to predict risk for these injuries, we performed genome-wide association screens for these injuries using data from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort consisting of 102,979 individuals. We did not find any single nucleotide polymorphisms (SNPs) associated with either of these injuries with a p-value that was genome-wide significant (p
