Int J Clin Exp Med 2014;7(3):586-596 www.ijcem.com /ISSN:1940-5901/IJCEM1401027
Original Article Gastroprotective effect of minocycline in experimentally induced gastric ulcers in rats Abdulrahman Al Asmari1, Saud Al Omani2, Malfi Al Otaibi3, Abdul-Aziz Al Abdulaaly4, Ibrahim Elfaki1, Khalid Al Yahya5, Mohammed Arshaduddin1 Research Center, Departments of 2Surgery, 3Gastroenterology, 4Hematology, 5Pharmacy, Prince Sultan Military Medical City, Riyadh, Saudi Arabia 1
Received January 11, 2014; Accepted February 20, 2014; Epub March 15, 2014; Published March 30, 2014 Abstract: Minocycline (MCN), a semi-synthetic tetracycline derivative possesses pleiotropic effects and provides protection against a number of disease models. However its effect on gastric ulcers has not been studied. The present investigation was undertaken, to study the gastro-protective potential of MCN in experimentally induced gastric ulcers in rats. MCN (10, 30, 100 mg/Kg) was tested for gastric secretion and antiulcer activity in different groups of Wistar rats. Gastric secretion and acidity studies were performed in pylorus ligated rats while indices of gastric ulcers were measured in ethanol (1 ml-100%) and indomethacin (30 mg/kg), induced gastric ulcers. Histological changes and the levels of gastric wall mucus, malondialdehyde (MDA), non-protein sulfhydryl (NP-SH), and myeloperoxidase (MPO), were used to assess ethanol induced gastric mucosal injuries. Exposure of rats to ulcerogens resulted in gastric mucosal injury and a significant increase in the indices of ulcer. MCN conferred a protective effect against ethanol, and indomethacin induced gastric mucosal injuries. Treatment with MCN, resulted in a significant decrease in the amount of gastric secretion, and total acidity and significantly (P
Original Article Gastroprotective effect of minocycline in experimentally induced gastric ulcers in rats Abdulrahman Al Asmari1, Saud Al Omani2, Malfi Al Otaibi3, Abdul-Aziz Al Abdulaaly4, Ibrahim Elfaki1, Khalid Al Yahya5, Mohammed Arshaduddin1 Research Center, Departments of 2Surgery, 3Gastroenterology, 4Hematology, 5Pharmacy, Prince Sultan Military Medical City, Riyadh, Saudi Arabia 1
Received January 11, 2014; Accepted February 20, 2014; Epub March 15, 2014; Published March 30, 2014 Abstract: Minocycline (MCN), a semi-synthetic tetracycline derivative possesses pleiotropic effects and provides protection against a number of disease models. However its effect on gastric ulcers has not been studied. The present investigation was undertaken, to study the gastro-protective potential of MCN in experimentally induced gastric ulcers in rats. MCN (10, 30, 100 mg/Kg) was tested for gastric secretion and antiulcer activity in different groups of Wistar rats. Gastric secretion and acidity studies were performed in pylorus ligated rats while indices of gastric ulcers were measured in ethanol (1 ml-100%) and indomethacin (30 mg/kg), induced gastric ulcers. Histological changes and the levels of gastric wall mucus, malondialdehyde (MDA), non-protein sulfhydryl (NP-SH), and myeloperoxidase (MPO), were used to assess ethanol induced gastric mucosal injuries. Exposure of rats to ulcerogens resulted in gastric mucosal injury and a significant increase in the indices of ulcer. MCN conferred a protective effect against ethanol, and indomethacin induced gastric mucosal injuries. Treatment with MCN, resulted in a significant decrease in the amount of gastric secretion, and total acidity and significantly (P
