IDCases 8 (2017) 87–88
Contents lists available at ScienceDirect
IDCases journal homepage: www.elsevier.com/locate/idcr
Case illustrated
Gastric syphilis Jianfei Caia , Danian Jib,c, Jian-long Guana,b,c,* a
Division of Immunology and Rheumatology, Huadong Hospital, P.R. China Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, P.R. China c Research Center on Aging and Medicine, Fudan University, Shanghai 200040, P.R. China b
A R T I C L E I N F O
Article history: Received 5 January 2017 Received in revised form 5 March 2017 Accepted 21 March 2017 Keywords: Gastric syphilis Gastroscopy Pathology
A B S T R A C T
Syphilis is a chronic systemic infectious disease. Gastric involvement is uncommon. We report of a 55-year-old female patient with a history of epigastric pain and a diagnosis of Syphilis confirmed by main clinical symptoms, tolulized red unheated serum test(TRUST) and treponema pallidum hemagglutination assay(TPHA). At the same time, we still reported gastric involvement about syphilis in this patient with gastroscopy and pathology. © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
A 55-year old woman presented at outpatient with a 3-month history of multiple nonpruritic, plaques on her palms and soles (Fig. 1A and B), and subsequently began have frequent abdominal pain, bloating and belching. Ranitidine was prescribed without improvement. The gastroscopy examination revealed more than 10 well circumscribed ulcerative lesions (Fig. 1C). Mucosal biopsy revealed an inflammatory infiltrate with multiple mature plasma cells (Fig. 1D). Tolulized red unheated serum test(TRUST) was
positive with a titer of 1:64, and a Treponema pallidum hemagglutination assay(TPHA) was positive. She reported no earlier history of chancres or associated fever, malaise, headache, or arthralgia. The woman was treated with a single intramuscular dose of 2.4 million units of penicillin G benzathine and the gastric symptoms resolved within 4 weeks.
* Corresponding author at: Division of Immunology and Rheumatology, Huadong Hospital; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital; Research Center on Aging and Medicine, Fudan University; #221 yan'an west Road, Shanghai 200040, P.R.China. E-mail address: [email protected] (J.-l. Guan). http://dx.doi.org/10.1016/j.idcr.2017.03.008 2214-2509/© 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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J. Cai et al. / IDCases 8 (2017) 87–88
Fig. 1. (A) and (B) showing erythematous plaques on the palms and soles of the woman. (C) Gastroscopy showing multiple irregular, clear boundary, and extensive lesions in the gastric body. (D) Histologic of gastroscopy showing a large number of inflammatory cells.
Contents lists available at ScienceDirect
IDCases journal homepage: www.elsevier.com/locate/idcr
Case illustrated
Gastric syphilis Jianfei Caia , Danian Jib,c, Jian-long Guana,b,c,* a
Division of Immunology and Rheumatology, Huadong Hospital, P.R. China Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, P.R. China c Research Center on Aging and Medicine, Fudan University, Shanghai 200040, P.R. China b
A R T I C L E I N F O
Article history: Received 5 January 2017 Received in revised form 5 March 2017 Accepted 21 March 2017 Keywords: Gastric syphilis Gastroscopy Pathology
A B S T R A C T
Syphilis is a chronic systemic infectious disease. Gastric involvement is uncommon. We report of a 55-year-old female patient with a history of epigastric pain and a diagnosis of Syphilis confirmed by main clinical symptoms, tolulized red unheated serum test(TRUST) and treponema pallidum hemagglutination assay(TPHA). At the same time, we still reported gastric involvement about syphilis in this patient with gastroscopy and pathology. © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
A 55-year old woman presented at outpatient with a 3-month history of multiple nonpruritic, plaques on her palms and soles (Fig. 1A and B), and subsequently began have frequent abdominal pain, bloating and belching. Ranitidine was prescribed without improvement. The gastroscopy examination revealed more than 10 well circumscribed ulcerative lesions (Fig. 1C). Mucosal biopsy revealed an inflammatory infiltrate with multiple mature plasma cells (Fig. 1D). Tolulized red unheated serum test(TRUST) was
positive with a titer of 1:64, and a Treponema pallidum hemagglutination assay(TPHA) was positive. She reported no earlier history of chancres or associated fever, malaise, headache, or arthralgia. The woman was treated with a single intramuscular dose of 2.4 million units of penicillin G benzathine and the gastric symptoms resolved within 4 weeks.
* Corresponding author at: Division of Immunology and Rheumatology, Huadong Hospital; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital; Research Center on Aging and Medicine, Fudan University; #221 yan'an west Road, Shanghai 200040, P.R.China. E-mail address: [email protected] (J.-l. Guan). http://dx.doi.org/10.1016/j.idcr.2017.03.008 2214-2509/© 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Fig. 1. (A) and (B) showing erythematous plaques on the palms and soles of the woman. (C) Gastroscopy showing multiple irregular, clear boundary, and extensive lesions in the gastric body. (D) Histologic of gastroscopy showing a large number of inflammatory cells.
