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Functional Streams and Cortical Integration in the Human Brain Jorge Sepulcre Neuroscientist published online 15 April 2014 DOI: 10.1177/1073858414531657 The online version of this article can be found at: http://nro.sagepub.com/content/early/2014/04/15/1073858414531657

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NROXXX10.1177/1073858414531657The NeuroscientistSepulcre

Article

Functional Streams and Cortical Integration in the Human Brain

The Neuroscientist 1­–10 © The Author(s) 2014 Reprints and permissions: sagepub.com/journalsPermissions.nav DOI: 10.1177/1073858414531657 nro.sagepub.com

Jorge Sepulcre1,2

Abstract The processing of brain information relies on the organization of neuronal networks and circuits that in the end must provide the substrate for human cognition. However, the presence of highly complex and multirelay neuronal interactions has limited our ability to disentangle the assemblies of brain systems. The present review article focuses on the latest developments to understand the architecture of functional streams of the human brain at the large-scale level. Particularly, this article presents a comprehensive framework and recent findings about how the highly modular sensory cortex, such as the visual, somatosensory, auditory, as well as motor cortex areas, connects to more parallelorganized cortical hubs in the brain’s functional connectome. Keywords functional streams, cortical integration, multimodal integration, multisensory, visual-motor, auditory-motor

Brain Graphs in the Study of Systems Neuroscience The human brain is organized and structured by means of multifaceted interactions between neuronal systems. The difficulty of disentangling distributed neuronal assemblies has boosted an intensive development of analytical methods aimed to study in vivo brain functional networks. For instance, one recent and prominent methodological approach to study the functional connections of brain regions is the combination of resting-state MRI (rs-MRI) and graph theory (Bullmore and Sporns 2009; Sepulcre and others 2012a; Sporns 2013a, 2013b; TurkBrowne 2013; Wig and others 2011). rs-MRI makes use of the synchrony of spontaneous low-frequency (

Functional streams and cortical integration in the human brain.

The processing of brain information relies on the organization of neuronal networks and circuits that in the end must provide the substrate for human ...
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